{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:40:09Z","timestamp":1792431609315,"version":"4.5.0"},"reference-count":208,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    PtdIns(3,4,5)P\n                    <jats:sub>3<\/jats:sub>\n                    and PtdIns(3,4)P\n                    <jats:sub>2<\/jats:sub>\n                    are second messengers and key regulators of tumorigenesis. Their production and degradation are spatiotemporally regulated by a network of phosphoinositide kinases and phosphatases which is frequently altered in cancer. Both molecules serve\u00a0as docking and activation sites for PH-domain containing effector proteins regulating oncogenic traits. This review will detail the proteins and pathways involved in\u00a0the\u00a0upstream regulation and downstream functions of PtdIns(3,4,5)P\n                    <jats:sub>3<\/jats:sub>\n                    and PtdIns(3,4)P\n                    <jats:sub>2<\/jats:sub>\n                    . In addition, it will cover the spatiotemporal distribution of these two PtdIns and relevant analysis techniques.\n                  <\/jats:p>","DOI":"10.1515\/hsz-2026-0181","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:55:51Z","timestamp":1792428951000},"source":"Crossref","is-referenced-by-count":0,"title":["Functional role of the second messengers PtdIns(3,4,5)P\n                    <sub>3<\/sub>\n                    and PtdIns(3,4)P\n                    <sub>2<\/sub>\n                    in carcinogenesis"],"prefix":"10.1515","author":[{"given":"Nina","family":"Nelson","sequence":"first","affiliation":[{"name":"Center for Experimental Medicine , Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 52, D-20246 Hamburg , Germany"},{"name":"MSH Medical School Hamburg , Institute for Systems Medicine , Am Kaiserkai 1, D-20457 Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2176-6526","authenticated-orcid":false,"given":"Manfred","family":"J\u00fccker","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine , Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf , Martinistra\u00dfe 52, D-20246 Hamburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"2026101916554688091_j_hsz-2026-0181_ref_001","doi-asserted-by":"crossref","unstructured":"Al-Alwan, M., Hou, S., Zhang, T.T., Makondo, K., and Marshall, A.J. 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