{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:39:18Z","timestamp":1764290358999,"version":"3.46.0"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_ijamh-2017-0020_s_999_w2aab3b7c37b1b6b1aab1c16b1Aa\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the prevalence, secular trends and associations of heart disease in a large unscreened, otherwise basically healthy, adolescent population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_ijamh-2017-0020_s_998_w2aab3b7c37b1b6b1aab1c16b2Aa\">\n                    <jats:title>Subjects and methods:<\/jats:title>\n                    <jats:p>Cross-sectional study of the cardiac status of 113,694 adolescents from the northern district of Israel, who completed the profiling process between the ages of 16 and 19, including all essential measures over a 22-year period.<\/jats:p>\n                    <jats:p>Results of imaging were categorized as either isolated valvar or structural abnormalities, and their clinically significant subgroups defined prospectively. The findings were correlated with the socio-demographic and anthropometric data and non-cardiac health conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_ijamh-2017-0020_s_997_w2aab3b7c37b1b6b1aab1c16b3Aa\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of those sent for echocardiography, 1257 (0.93% of the total population) had isolated valvar disease and 216 (0.19%) had structural abnormalities, with 20% of both groups considered significant. Females had lower prevalence of heart disease. There was peak prevalence in the second 5-year period. Tall subjects or a past history of rheumatic fever had more valvar abnormalities. Thin subjects or those with skeletal anomalies had more structural abnormalities. Significant valvar and structural anomalies were more common in subjects with learning disorders, endocrine disorders and diabetes mellitus. Fewer valvar abnormalities were diagnosed in obese subjects. Heart disease was more common in those with non-solid tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_ijamh-2017-0020_s_996_w2aab3b7c37b1b6b1aab1c16b4Aa\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Appreciable numbers of potentially healthy adolescents were found to have heart disease. There appeared to be an association with body size, skeletal abnormalities and relatively common medical disorders, the cause of which remains to be determined in prospective studies that could change the way common adolescent disease should be followed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/ijamh-2017-0020","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T06:01:10Z","timestamp":1497420070000},"source":"Crossref","is-referenced-by-count":3,"title":["Cardiac anomalies and associated comorbidities in a large adolescent population"],"prefix":"10.1515","volume":"31","author":[{"given":"Daniel Lyon","family":"Fink","sequence":"first","affiliation":[{"name":"Shaare Zedek Medical Center , Jerusalem , Israel"},{"name":"Medical Corps , Israel Defense Forces (IDF) , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yossy","family":"Machluf","sequence":"additional","affiliation":[{"name":"Medical Corps , Israel Defense Forces (IDF) , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivka","family":"Farkash","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giora","family":"Weisz","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center , Jerusalem , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinoam","family":"Pirogovsky","sequence":"additional","affiliation":[{"name":"Medical Corps , Israel Defense Forces (IDF) , Tel Aviv , Israel"},{"name":"Schneider Children Medical Center , Petah Tikva , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orna","family":"Tal","sequence":"additional","affiliation":[{"name":"Assaf Harofeh Medical Center , Tzrifin , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Dagan","sequence":"additional","affiliation":[{"name":"Medical Corps , Israel Defense Forces (IDF) , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoram","family":"Chaiter","sequence":"additional","affiliation":[{"name":"Head of Quality Assurance and Control of Medical Committees, Medical Corps (IDF), Epidemiologist , Pinsker 72 street , Haifa 32712 , Israel , Phone: +972-4-8320751; +972-50-5510044"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Karan A, Engelgau M, Mahal A. 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