{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T04:55:34Z","timestamp":1764305734134,"version":"3.46.0"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_ijamh-2019-0109_s_999\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>More remains to be known about polycystic ovary syndrome (PCOS) among overweight\/obese adolescents across different ethnicities especially in regards to mental illness as an associated comorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_ijamh-2019-0109_s_998\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence of PCOS among overweight and obese adolescents and to evaluate known risk factors for PCOS in a diverse population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_ijamh-2019-0109_s_997\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Charts of patients at an Adolescent Clinic between April 1, 2016 and July 30, 2018 were filtered using: obese, overweight and body mass index (BMI) &gt;85%. Charts were reviewed to identify the presence of PCOS using National Institutes of Health (NIH) criteria, race\/ethnicity and known risk factors for PCOS [lipid, BMI, glycated hemoglobin (HA\n                      <jats:sub>1c<\/jats:sub>\n                      ), blood pressure (BP)] and mental health conditions associated with PCOS (anxiety\/depression and self-harm\/suicidal ideation).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_ijamh-2019-0109_s_996\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with PCOS were more likely to have elevated lipids (19.6% vs. 9.9%, p = 0.05), be obese (67.4% vs. 50.9%, p = 0.03), and have acanthosis nigricans (68.9% vs. 28.2%, p =&lt; 0.001). PCOS was more common among non-Hispanic patients (77.9%) vs. Hispanic patients (57.8%). There was no difference in the prevalence of depression\/anxiety (37% vs. 33%, respectively, p = 0.590) or self \u2013 harm\/suicidal ideation (17% vs. 17%, p = 0.96) in patients with and without PCOS. In a logistic regression model, after adjusting for all demographics and clinical features, ethnicity, acanthosis nigricans and BMI were significant risk factors for PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_ijamh-2019-0109_s_995\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with PCOS are more likely to be obese, hyperlipidemic, have acanthosis nigricans and be of non-Hispanic ethnicity. However, there was no difference in the prevalence of depression\/anxiety and self-harm\/suicidal ideation among adolescents with or without PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/ijamh-2019-0109","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T04:02:00Z","timestamp":1578715320000},"source":"Crossref","is-referenced-by-count":16,"title":["Prevalence and risk factors of polycystic ovarian syndrome among an ethnically diverse overweight\/obese adolescent population"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-4633","authenticated-orcid":false,"given":"Jacqueline","family":"Maya","sequence":"first","affiliation":[{"name":"Department of Pediatrics , Elmhurst Hospital Center , Elmhurst, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Siegel","sequence":"additional","affiliation":[{"name":"Adolescent Clinic, Department of Pediatrics , Icahn School of Medicine at Mount Sinai\/Elmhurst Hospital Center , Elmhurst, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina Q.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Pediatrics , Icahn School of Medicine at Mount Sinai\/Elmhurst Hospital Center , Elmhurst, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaina","family":"Rousseau-Pierre","sequence":"additional","affiliation":[{"name":"Adolescent Clinic, Department of Pediatrics , Icahn School of Medicine at Mount Sinai\/Elmhurst Hospital Center , Elmhurst, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,1,11]]},"reference":[{"key":"2025112723552363155_j_ijamh-2019-0109_ref_001","doi-asserted-by":"crossref","unstructured":"Ding T, Hardiman PJ, Petersen I, Wang FF, Qu F, Baio G. The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis. Oncotarget. 2017;8(56):96351\u201358.","DOI":"10.18632\/oncotarget.19180"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_002","doi-asserted-by":"crossref","unstructured":"Wang S, ALvero R. Racial and ethnic differences in physiology and clinical symptoms of polycystic ovary syndrome. Emin Reprod Med. 2013;31:365\u20139.","DOI":"10.1055\/s-0033-1348895"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_003","doi-asserted-by":"crossref","unstructured":"Ybarra M, Franco RR, Cominato L, Sampaio RB, Sucena da Rocha SM, Damiani D. Polycystic Ovary Syndrome among obese adolescents. Gynecol Endocrinol. 2017;34(1):45\u20138.","DOI":"10.1080\/09513590.2017.1359250"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_004","doi-asserted-by":"crossref","unstructured":"Mehta J, Kamdar V, Dumesic D. Phenotypic expression of polycystic ovary syndrome in south East Asian women. Obstet Gynecol Surv. 2013;68(3):228\u201334.","DOI":"10.1097\/OGX.0b013e318280a30f"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_005","doi-asserted-by":"crossref","unstructured":"Javed A, Chelvakumar G, Bonny AE. Polycystic ovary syndrome in adolescents: a review of past year evidence. Curr Opin Obstet Gynecol. 2016;28:373\u201380.","DOI":"10.1097\/GCO.0000000000000301"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_006","doi-asserted-by":"crossref","unstructured":"Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106:6\u201315.","DOI":"10.1016\/j.fertnstert.2016.05.003"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_007","doi-asserted-by":"crossref","unstructured":"Nur MM, Newman IN, Siqueira L. Glucose metabolism in overweight Hispanic adolescents with and without polycystic ovary syndrome. Pediatrics. 2009;124(3):e496\u2013502.","DOI":"10.1542\/peds.2008-2050"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_008","doi-asserted-by":"crossref","unstructured":"Mani H, Davies M, Bodicoat DH, Levy MJ, Gray LJ, Howlett TA, et al. Clinical characteristics of polycystic ovary syndrome: investigating differences in White and South Asian women. Clin Endocrinol. 2015;83:542\u20139.","DOI":"10.1111\/cen.12784"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_009","doi-asserted-by":"crossref","unstructured":"Jedel E, Waern M, Gustafson D, Landen M, Eriksson E, Holm G, et al. Anxiety and depression symptoms in women with polycystic ovary syndrome compared with controls matched for body max index. Hum Reprod. 2010;25(2):450\u20136.","DOI":"10.1093\/humrep\/dep384"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_010","doi-asserted-by":"crossref","unstructured":"Hollinrake E, Abreu A, Maifeld M, Van Voorhis BJ, Dokras A. Increased risk of depressive disorders in women with polycystic ovary syndrome. Fertil Steril. 2007;87(6):1369\u201376.","DOI":"10.1016\/j.fertnstert.2006.11.039"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_011","doi-asserted-by":"crossref","unstructured":"Brutocao C, Zaiem F, Alsawas M, Morrow AS, Murad HM, Javed A. Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine. 2018;62:318\u201325.","DOI":"10.1007\/s12020-018-1692-3"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_012","doi-asserted-by":"crossref","unstructured":"Milsom SR, Nair SM, Ogilvie CM, Stewart JM, Merry SN. Polycystic ovary syndrome and depression in New Zealand adolescents. J Pediatr Adol Gynec. 2013;26:142\u20137.","DOI":"10.1016\/j.jpag.2012.11.013"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_013","doi-asserted-by":"crossref","unstructured":"Banba V. Update on screening, etiology, and treatment of dyslipidemia in children. J Clin. Endocrinol. 2014;99:3093\u2013102.","DOI":"10.1210\/jc.2013-3860"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_014","doi-asserted-by":"crossref","unstructured":"Copeland KC, Silverstein J, Moore KR, Prazar GE, Raymer T, Shiffman RN, et al. Clinical practice guideline: management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics. 2013;131(2):364\u201382.","DOI":"10.1542\/peds.2012-3494"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_015","doi-asserted-by":"crossref","unstructured":"Zuckerbrot RA, Cheung A, Jensen PS, Stein RE, Laraque D. Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management. Pediatrics. 2018;141(3):e20174081.","DOI":"10.1542\/peds.2017-4081"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_016","doi-asserted-by":"crossref","unstructured":"Gilbody S, Richards D, Brealey S, Hewitt C. Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-analysis. J Gen Intern Med. 2007;11:1596\u2013602.","DOI":"10.1007\/s11606-007-0333-y"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_017","doi-asserted-by":"crossref","unstructured":"Manea L, Gilbody S, McMillan D. Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis. Can Med Assoc J. 2012;184(3):E191\u20136.","DOI":"10.1503\/cmaj.110829"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_018","doi-asserted-by":"crossref","unstructured":"Mossman SA, Luft MJ, Schroeder HK, Varney ST, Fleck DE, Barzman DH, et al. The Generalized Anxiety Disorder 7-itm (GAD-7) scale in adolescents with generalized anxiety disorder: signal detection and validation. Ann Clin Psychiatry. 2017;29(4):227\u201334A.","DOI":"10.1177\/104012371702900404"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_019","doi-asserted-by":"crossref","unstructured":"Moran C, Tena G, Moran S, Ruiz P, Reyna R, Duque X. Prevalence of polycystic ovary. Gynecol Obstet Invest. 2010;69:274\u201380.","DOI":"10.1159\/000277640"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_020","doi-asserted-by":"crossref","unstructured":"Goodarzi MO, Quinones MJ, Azziz R, Rotter JI, Hsueh WA, Yang H. Polycystic ovary syndrome and related disorders in Mexican Women. Syndrome and related disorders in Mexican-Americans: prevalence and association with the severity of insulin resistance. Fertil Steril. 2005;83:766\u20139.","DOI":"10.1016\/j.fertnstert.2005.03.051"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_021","doi-asserted-by":"crossref","unstructured":"Rodin DA, Bano G, Bland JM, Taylor K, Nussey SS. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women. Clin Endocrinol. 1998;49:91\u20139.","DOI":"10.1046\/j.1365-2265.1998.00492.x"},{"key":"2025112723552363155_j_ijamh-2019-0109_ref_022","doi-asserted-by":"crossref","unstructured":"Yang AY, OShiro J, Ayers C, Auchus RJ. Influence of race\/ethnicity on cardiovascular risk factors in polycystic ovary syndrome, the Dallas Heart Study. Clin Endocrinol. 2016;85(1):92\u20139.","DOI":"10.1111\/cen.12986"}],"container-title":["International Journal of Adolescent Medicine and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/ijamh\/ahead-of-print\/article-10.1515-ijamh-2019-0109\/article-10.1515-ijamh-2019-0109.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/ijamh-2019-0109\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/ijamh-2019-0109\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T23:55:51Z","timestamp":1764287751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/ijamh-2019-0109\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,11]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,11]]},"published-print":{"date-parts":[[2022,2,28]]}},"alternative-id":["10.1515\/ijamh-2019-0109"],"URL":"https:\/\/doi.org\/10.1515\/ijamh-2019-0109","relation":{},"ISSN":["2191-0278"],"issn-type":[{"type":"electronic","value":"2191-0278"}],"subject":[],"published":{"date-parts":[[2020,1,11]]},"article-number":"20190109"}}