{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:48:09Z","timestamp":1745412489907},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p> Alcohol and illicit drug abuse are major public health problems worldwide. Since alcohol is the predominant substance of choice in polydrug abusers, monitoring its use, along with urinary drug screening in patients in rehabilitation programs, appeared to be crucial in identifying patients at risk of alcohol disorders leading to impaired quality of life. Ethyl \u03b2-D-6-glucuronide, a non-oxidative, non-volatile, stable and minor direct ethanol metabolite, has a 6h to 4 day window of detection in urine after the last alcohol intake. Each of the 119 subjects (85 males, 34 females) registered with the Public Health Service for Drug Dependence Treatment provided a urine sample for ethylglucoronide (EtG) determination in an immunochemical test with a 500 ng\/ml cutoff. All results were evaluated with confirmation criteria of a fully validated gas chromatography\/mass spectrometry assay. The diagnostic performance of the EtG immunochemical test was assessed using Receiver Operating Characteristic Curve analysis. The immunochemical test specificity was 100% for EtG urinary values above 500 ng\/ml. No false positive results were found. With levels below 500 ng\/ml, 12% of the samples were classified as negative. The average consumption of the incorrectly classified subjects was 171 ng\/ml, with a misclassification error of 6.5% to 18.5%. High agreement between EtG as determined in an immunochemical test and gas chromatography\/mass spectrometry, suggests that the rapid EtG test is a reliable, cost-effective alcohol monitoring assay for patient management in many non-forensic settings, such as drug rehabilitation programs.<\/jats:p>","DOI":"10.1515\/intox-2017-0022","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T11:35:14Z","timestamp":1525347314000},"page":"155-162","source":"Crossref","is-referenced-by-count":7,"title":["Monitoring people at risk of drinking by a rapid urinary ethyl glucuronide test"],"prefix":"10.1515","volume":"10","author":[{"given":"Nadia","family":"Fucci","sequence":"first","affiliation":[{"name":"Forensic Medicine Section, Public Health Institute, Sacred Heart Catholic University, Largo Francesco Vito, 1- 00168 Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Gili","sequence":"additional","affiliation":[{"name":"Hygiene and Public Health Section, Department of Experimental Medicine, University of Perugia, Piazza Lucio Severi- 06132 Perugia , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyriaki","family":"Aroni","sequence":"additional","affiliation":[{"name":"Forensic Medicine, Forensic Science and Sports Medicine Section, Department of Surgical and Biomedical Science, University of Perugia, Piazza Lucio Severi, 06132 Perugia , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Carletti","sequence":"additional","affiliation":[{"name":"Local Health Unit, USL Umbria 2, Ser.T Perugia, Ospedale S. Maria della Misericordia, 06132 Perugia , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo Lorenzo","family":"Pascali","sequence":"additional","affiliation":[{"name":"Forensic Medicine Section, Public Health Institute, Sacred Heart Catholic University, Largo Francesco Vito, 1- 00168 Rome , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Gambelunghe","sequence":"additional","affiliation":[{"name":"Forensic Medicine, Forensic Science and Sports Medicine Section Department of Surgical and Biomedical Science Piazza Lucio Severi, 06132 Perugia , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"2021040721395380622_j_intox-2017-0022_ref_001_w2aab3b7b3b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"Bertholet N, Winter MR, Cheng DM, Samet JH, Saitz R. (2014). 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