{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T19:37:27Z","timestamp":1777059447303,"version":"3.51.4"},"reference-count":124,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence rates of adverse events secondary to any operation are a well-known problem in any surgical field. One outstanding example of such adverse events is postoperative pain. Thus, the incidence of acute postoperative pain following any surgical procedure and its treatment are central issues for every surgeon. In the times of Enhanced Recovery After Surgery (ERAS) programs, acute pain therapy became an increasingly well investigated and accepted aspect in almost all surgical subspecialties. However, if it comes to the reduction of postoperative complications, in the actual context of postoperative pain, surgeons tend to focus on the operative process rather than on the perioperative procedures. Undoubtedly, postoperative pain became an important factor with regard to the quality of surgical care: both, the extent and the quality of the surgical procedure and the extent and the quality of the analgesic technique are decisive issues for a successful pain management. There is growing evidence that supports the role of acute pain therapy in reducing postoperative morbidity, and it has been demonstrated that high pain scores postoperatively may contribute to a complicated postoperative course. This overview comprises the current knowledge on the role of acute pain therapy with regard to the occurrence of postoperative complications. Most of the knowledge is derived from studies that primarily focus on the type and quality of postoperative pain therapy in relation to specific surgical procedures and only secondary on complications. As far as existent, data that report on the recovery period after surgery, on the rehabilitation status, on perioperative morbidity, on the development of chronic pain after surgery, and on possible solutions of the latter problem with the institution of transitional pain services will be presented.<\/jats:p>","DOI":"10.1515\/iss-2019-0008","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T09:02:37Z","timestamp":1574758957000},"page":"158-166","source":"Crossref","is-referenced-by-count":4,"title":["Pain therapy to reduce perioperative complications"],"prefix":"10.1515","volume":"4","author":[{"given":"Stephan M.","family":"Freys","sequence":"first","affiliation":[{"name":"Chirurgische Klinik, DIAKO Ev. Diakonie-Krankenhaus, Gr\u00f6pelinger Heerstr. 406-408, 28239 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Pogatzki-Zahn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref271","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jclinane.2018.07.008","article-title":"Comparison of the postoperative effect between epidural anesthesia and continuous wound infiltration on patients with open surgeries: a meta-analysis","volume":"51","year":"2018","journal-title":"J Clin Anesth"},{"key":"ref1191","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.sjpain.2016.02.008","article-title":"New approach for treatment of prolonged postoperative pain: APS out-patient clinic","volume":"12","year":"2016","journal-title":"Scand J Pain"},{"key":"ref1141","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1200\/JCO.2016.70.3413","article-title":"Clinical prediction model and tool for assessing risk of persistent pain after breast cancer surgery","volume":"35","year":"2017","journal-title":"J Clin Oncol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.surge.2010.07.011","article-title":"Surgery induced immunosuppression","volume":"9","year":"2011","journal-title":"Surgeon"},{"key":"ref1011","doi-asserted-by":"crossref","first-page":"24.e1","DOI":"10.1016\/j.jpain.2013.08.014","article-title":"EDONIS Investigating Group, Dubray C. 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Anaesthesiol"},{"key":"ref761","first-page":"1248","article-title":"Effects of single-dose dexmedetomidine on the quality of recovery after modified radical mastectomy: a randomised controlled trial","volume":"79","year":"2013","journal-title":"Minerva Anestesiol"},{"key":"ref1211","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2217\/pmt-2016-0004","article-title":"Chronic postsurgical pain and persistent opioid use following surgery: the need for a transitional pain service","volume":"6","year":"2016","journal-title":"Pain Manag"},{"key":"ref961","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jclinane.2018.03.005","article-title":"Epidural compared with non-epidural analgesia and cardiopulmonary complications after colectomy: a retrospective cohort study of 20,880 patients using a national quality database","volume":"47","year":"2018","journal-title":"J Clin Anesth"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1245\/s10434-014-3923-z","article-title":"Paravertebral blocks in patients undergoing mastectomy with or without immediate reconstruction provides improved pain control and decreased postoperative nausea and vomiting","volume":"21","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"ref711","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.surge.2010.07.011","article-title":"Surgery induced immunosuppression","volume":"9","year":"2011","journal-title":"Surgeon"},{"key":"ref681","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1089\/lap.2017.0338","article-title":"A comparison of multimodal analgesic approaches in institutional enhanced recovery after surgery protocols for colorectal surgery: pharmacological agents","volume":"27","year":"2017","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1213\/01.ANE.0000157121.71808.04","article-title":"The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery","volume":"101","year":"2005","journal-title":"Anesth Analg"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/SLA.0000000000001541","article-title":"Hospital analgesia practices an patient-reported pain after colorectal resection","volume":"264","year":"2016","journal-title":"Ann Surg"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.sjpain.2016.02.008","article-title":"New approach for treatment of prolonged postoperative pain: APS out-patient clinic","volume":"12","year":"2016","journal-title":"Scand J Pain"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/ALN.0b013e318297630d","article-title":"Perioperative systemic magnesium to minimize postoperative pain meta-analysis of randomized controlled trials","volume":"119","year":"2013","journal-title":"Anesthesiology"},{"key":"ref891","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jclinane.2018.07.008","article-title":"Comparison of the postoperative effect between epidural anesthesia and continuous wound infiltration on patients with open surgeries: a meta-analysis","volume":"51","year":"2018","journal-title":"J Clin Anesth"},{"key":"ref1231","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jamcollsurg.2018.07.659","article-title":"Opioid-prescribing guidelines for common surgical procedures: an expert panel consensus","volume":"227","year":"2018","journal-title":"J Am Coll Surg"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/AAP.0000000000000163","article-title":"Pectoral nerves I and II blocks in multimodal analgesia for breast cancer surgery: a randomized clinical trial","volume":"40","year":"2015","journal-title":"Reg Anesth Pain Med"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1034\/j.1399-6576.1999.430714.x","article-title":"Single-injection paravertebral block compared to general anaesthesia in breast surgery","volume":"43","year":"1999","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref871","first-page":"102","article-title":"Postoperative analgesia after total-hip arthroplasty: comparison of intravenous patient-controlled analgesia with morphine and single injection of femoral nerve or psoas compartment block: a prospective, randomized, double-blind study","volume":"29","year":"2004","journal-title":"Reg Anesth Pain Med"},{"key":"ref861","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1097\/00000542-200506000-00020","article-title":"Effect of postoperative epidural analgesia on rehabilitation and pain after hip fracture surgery: a randomised, double-blind, placebo-controlled 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children","volume":"6","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"ref141","first-page":"1248","article-title":"Effects of single-dose dexmedetomidine on the quality of recovery after modified radical mastectomy: a randomised controlled trial","volume":"79","year":"2013","journal-title":"Minerva Anestesiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/ALN.0b013e31828866b3","article-title":"Pain intensity on the first day after surgery: a prospective cohort study comparing 179 surgical procedures","volume":"118","year":"2013","journal-title":"Anesthesiology"},{"key":"ref651","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1097\/ALN.0b013e31828866b3","article-title":"Pain intensity on the first day after surgery: a prospective cohort study comparing 179 surgical procedures","volume":"118","year":"2013","journal-title":"Anesthesiology"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2217\/pmt-2016-0004","article-title":"Chronic postsurgical pain and persistent opioid use following surgery: the need for a transitional pain service","volume":"6","year":"2016","journal-title":"Pain Manag"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1177\/0148607114523451","article-title":"ERAS \u2013 enhanced recovery after surgery: moving evidence-based perioperative care to practice","volume":"38","year":"2014","journal-title":"Parenter Enteral Nutr"},{"key":"ref981","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/bja\/aen300","article-title":"Effectiveness and safety of postoperative pain management: a survey of 18 925 consecutive patients between 1998 and 2006 (2nd revision) \u2013 a database analysis of prospectively raised data","volume":"101","year":"2008","journal-title":"Br J 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