{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:41:35Z","timestamp":1784997695468,"version":"3.55.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_iss-2019-1004_abs_001_w2aab3b7c27b1b6b1aab1c16b1Aa\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Total surgical resection is the gold standard in the treatment of craniopharyngioma. However, there is concern that aggressive surgical resection might result in high rates of endocrinologic, metabolic, and behavioral morbidities. Subtotal resection (SR) with subsequent radiation therapy (RT) may reduce surgical complications, but it may also increase the risk of tumor recurrence and radiation-induced side effects. Therefore, the optimal surgical strategy remains debatable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_iss-2019-1004_abs_002_w2aab3b7c27b1b6b1aab1c16b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To determine the optimal surgical strategy, we assessed the clinical courses of 39 patients (19 male patients and 20 female patients) with newly diagnosed craniopharyngioma who were treated at our institute. The median age at diagnosis was 34 years (range: 0\u201376 years). The median follow-up period was 8.5 years (range: 3\u2013160\u00a0months). Our treatment strategy comprised gross total resection (GTR) for craniopharyngioma in patients that were not at surgical risk. Conversely, after adequate tumor decompression, we used RT, mainly Gamma Knife radiosurgery, in patients at risk. We divided the patients into the following three groups depending on the treatment course: GTR, SR with RT, and SR with staged surgery. We compared tumor characteristics, as well as patients\u2019\u00a0conditions at the preoperative stage and last follow-up, among the three groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_iss-2019-1004_abs_003_w2aab3b7c27b1b6b1aab1c16b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 8, 21, and 10 patients in the GTR, SR with RT, and SR with staged surgery groups, respectively. There were no differences in the maximum tumor diameter, tumor volume, composition, and presence of calcification among the groups. Among the 39 patients, 24 underwent transcranial microsurgery and 15 underwent trans-sphenoidal surgery as the initial treatment. No cases involving surgical mortality, cerebrospinal fluid leakage, severely deteriorated visual function, or severe hypothalamic damage were observed. No tumor recurrence was noted in the GTR group. One patient required additional RT, and one patient underwent second surgery for tumor recurrence in the SR with RT group. In the SR with staged surgery group, 8 of the 10 patients eventually underwent RT, but tumor control was achieved in all patients at the latest follow-up. In this group, the third trans-sphenoidal surgery caused a severe vascular injury in one patient. At the final follow-up, 33 (85%) patients were undergoing anterior pituitary hormone replacement, and the rate of diabetes insipidus was 51%. There was no significant difference in the pituitary dysfunction rate among the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_iss-2019-1004_abs_004_w2aab3b7c27b1b6b1aab1c16b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We observed a low rate of surgical complications and a sufficient tumor control rate in response to our treatment strategy. Despite attempting preservation of the pituitary stalk, we found it difficult to rescue anterior pituitary function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/iss-2019-1004","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T14:52:57Z","timestamp":1604415177000},"page":"25-33","source":"Crossref","is-referenced-by-count":10,"title":["Surgical aspects in craniopharyngioma treatment"],"prefix":"10.1515","volume":"6","author":[{"given":"Shingo","family":"Fujio","sequence":"first","affiliation":[{"name":"Department of Neurosurgery , Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan"},{"name":"Pituitary Disorders Center, Kagoshima University Hospital , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Hanada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan"},{"name":"Pituitary Disorders Center, Kagoshima University Hospital , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yonenaga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan"},{"name":"Pituitary Disorders Center, Kagoshima University Hospital , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Habu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Arita","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan"},{"name":"Department of Neurosurgery , Izumi regional medical center , Akune , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan"},{"name":"Pituitary Disorders Center, Kagoshima University Hospital , Kagoshima , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"2021050422002306787_j_iss-2019-1004_ref_001_w2aab3b7c27b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Yamada, S, Fukuhara, N, Oyama, K, Takeshita, A, Takeuchi, Y, Ito, J, et\u00a0al. Surgical outcome in 90 patients with craniopharyngioma: an evaluation of transsphenoidal surgery. World Neurosurg 2010;74:320\u201330. https:\/\/doi.org\/10.1016\/j.wneu.2010.06.014.","DOI":"10.1016\/j.wneu.2010.06.014"},{"key":"2021050422002306787_j_iss-2019-1004_ref_002_w2aab3b7c27b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Hofmann, BM, H\u00f6llig, A, Strauss, C, Buslei, R, Buchfelder, M, Fahlbusch, R. Results after treatment of craniopharyngiomas: further experiences with 73 patients since 1997. J Neurosurg 2012;116:373\u201384. https:\/\/doi.org\/10.3171\/2011.6.jns081451.","DOI":"10.3171\/2011.6.JNS081451"},{"key":"2021050422002306787_j_iss-2019-1004_ref_003_w2aab3b7c27b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Morisako, H, Goto, T, Goto, H, Bohoun, CA, Tamrakar, S, Ohata, K. Aggressive surgery based on an anatomical subclassification of craniopharyngiomas. Neurosurg Focus 2016;41:E10. https:\/\/doi.org\/10.3171\/2016.9.focus16211.","DOI":"10.3171\/2016.9.FOCUS16211"},{"key":"2021050422002306787_j_iss-2019-1004_ref_004_w2aab3b7c27b1b6b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Sughrue, ME, Yang, I, Kane, AJ, Fang, S, Clark, AJ, Aranda, D, et\u00a0al. Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma. J Neuro Oncol 2011;101:463\u201376. https:\/\/doi.org\/10.1007\/s11060-010-0265-y.","DOI":"10.1007\/s11060-010-0265-y"},{"key":"2021050422002306787_j_iss-2019-1004_ref_005_w2aab3b7c27b1b6b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Mende, KC, Kellner, T, Petersenn, S, Honegger, J, Evangelista-Zamora, R, Droste, M, et\u00a0al. Clinical situation, therapy, and follow-up of adult craniopharyngioma. J Clin Endocrinol Metab 2020;105. pii: dgz043. https:\/\/doi.org\/10.1210\/clinem\/dgz043.","DOI":"10.1210\/clinem\/dgz043"},{"key":"2021050422002306787_j_iss-2019-1004_ref_006_w2aab3b7c27b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Smee, RI, Williams, JR, Kwok, B, Teo, C, Stening, W. Modern radiotherapy approaches in the management of craniopharyngiomas. J Clin Neurosci 2011;18:613\u20137. https:\/\/doi.org\/10.1016\/j.jocn.2010.12.005.","DOI":"10.1016\/j.jocn.2010.12.005"},{"key":"2021050422002306787_j_iss-2019-1004_ref_007_w2aab3b7c27b1b6b1ab2b1b7Aa","doi-asserted-by":"crossref","unstructured":"Schoenfeld, A, Pekmezci, M, Barnes, MJ, Tihan, T, Gupta, N, Lamborn, KR, et\u00a0al. The superiority of conservative resection and adjuvant radiation for craniopharyngiomas. J Neuro Oncol 2012;108:133\u20139. https:\/\/doi.org\/10.1007\/s11060-012-0806-7.","DOI":"10.1007\/s11060-012-0806-7"},{"key":"2021050422002306787_j_iss-2019-1004_ref_008_w2aab3b7c27b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Clark, AJ, Cage, TA, Aranda, D, Parsa, AT, Sun, PP, Auguste, KI, et\u00a0al. A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Childs Nerv Syst 2013;29:231\u20138. https:\/\/doi.org\/10.1007\/s00381-012-1926-2.","DOI":"10.1007\/s00381-012-1926-2"},{"key":"2021050422002306787_j_iss-2019-1004_ref_009_w2aab3b7c27b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Lee, MH, Kim, SH, Seoul, HJ, Nam, DH, Lee, JI, Park, K, et\u00a0al. Impact of maximal safe resection on the clinical outcome of adults with craniopharyngiomas. J Clin Neurosci 2012;19:1005\u20138. https:\/\/doi.org\/10.1016\/j.jocn.2011.09.033.","DOI":"10.1016\/j.jocn.2011.09.033"},{"key":"2021050422002306787_j_iss-2019-1004_ref_010_w2aab3b7c27b1b6b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Dadlani, R, Ghosal, N, Hegde, AS. Should adjuvant radiotherapy be recommended for pediatric craniopharyngiomas. J Korean Neurosurg Soc 2014;55:54\u20136. https:\/\/doi.org\/10.3340\/jkns.2014.55.1.54.","DOI":"10.3340\/jkns.2014.55.1.54"},{"key":"2021050422002306787_j_iss-2019-1004_ref_011_w2aab3b7c27b1b6b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Burman, P, van Beek, AP, Biller, BM, Camacho-H\u00fcbner, C, Mattsson, AF. Radiotherapy, especially at young age increases the risk for de novo brain tumors in patients treated for pituitary\/sellar lesions. J Clin Endocrinol Metab 2017;102:1051\u20138. https:\/\/doi.org\/10.1210\/jc.2016-3402.","DOI":"10.1210\/jc.2016-3402"},{"key":"2021050422002306787_j_iss-2019-1004_ref_012_w2aab3b7c27b1b6b1ab2b1c12Aa","doi-asserted-by":"crossref","unstructured":"Ya\u015fargil, MG, Curcic, M, Kis, M, Siegenthaler, G, Teddy, PJ, Roth, P. Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg 1990;73:3\u201311. https:\/\/doi.org\/10.3171\/jns.1990.73.1.0003.","DOI":"10.3171\/jns.1990.73.1.0003"},{"key":"2021050422002306787_j_iss-2019-1004_ref_013_w2aab3b7c27b1b6b1ab2b1c13Aa","doi-asserted-by":"crossref","unstructured":"Komotar, RJ, Starke, RM, Raper, DM, Anand, VK, Schwartz, TH. Endoscopic endonasal compared with microscopic transsphenoidal and open transcranial resection of craniopharyngiomas. World Neurosurg 2012;77:329\u201341. https:\/\/doi.org\/10.1016\/j.wneu.2011.07.011.","DOI":"10.1016\/j.wneu.2011.07.011"},{"key":"2021050422002306787_j_iss-2019-1004_ref_014_w2aab3b7c27b1b6b1ab2b1c14Aa","doi-asserted-by":"crossref","unstructured":"Gerganov, V, Metwali, H, Samii, A, Fahlbusch, R, Samii, M. Microsurgical resection of extensive craniopharyngiomas using a frontolateral approach: operative technique and outcome. J Neurosurg 2014;120:559\u201370. https:\/\/doi.org\/10.3171\/2013.9.jns122133.","DOI":"10.3171\/2013.9.JNS122133"},{"key":"2021050422002306787_j_iss-2019-1004_ref_015_w2aab3b7c27b1b6b1ab2b1c15Aa","doi-asserted-by":"crossref","unstructured":"Wannemuehler, TJ, Rubel, KE, Hendricks, BK, Ting, JY, Payner, TD, Shah, MV, et\u00a0al. Outcomes in transcranial microsurgery versus extended endoscopic endonasal approach for primary resection of adult craniopharyngiomas. Neurosurg Focus 2016;41:E6. https:\/\/doi.org\/10.3171\/2016.9.focus16314.","DOI":"10.3171\/2016.9.FOCUS16314"},{"key":"2021050422002306787_j_iss-2019-1004_ref_016_w2aab3b7c27b1b6b1ab2b1c16Aa","doi-asserted-by":"crossref","unstructured":"Cavallo, LM, Frank, G, Cappabianca, P, Solari, D, Mazzatenta, D, Villa, A, et\u00a0al. The endoscopic endonasal approach for the management of craniopharyngiomas: a series of 103 patients. J Neurosurg 2014;121:100\u201313. https:\/\/doi.org\/10.3171\/2014.3.jns131521.","DOI":"10.3171\/2014.3.JNS131521"},{"key":"2021050422002306787_j_iss-2019-1004_ref_017_w2aab3b7c27b1b6b1ab2b1c17Aa","doi-asserted-by":"crossref","unstructured":"Hara, T, Akutsu, H, Yamamoto, T, Tanaka, S, Takano, S, Ishikawa, E, et\u00a0al. Cranial base repair using suturing technique combined with a mucosal flap for cerebrospinal fluid leakage during endoscopic endonasal surgery. World Neurosurg 2015;84:1887\u201393. https:\/\/doi.org\/10.1016\/j.wneu.2015.08.025.","DOI":"10.1016\/j.wneu.2015.08.025"},{"key":"2021050422002306787_j_iss-2019-1004_ref_018_w2aab3b7c27b1b6b1ab2b1c18Aa","doi-asserted-by":"crossref","unstructured":"Horiguchi, K, Nishioka, H, Fukuhara, N, Yamaguchi-Okada, M, Yamada, S. A new multilayer reconstruction using nasal septal flap combined with fascia graft dural suturing for high-flow cerebrospinal fluid leak after endoscopic endonasal surgery. Neurosurg Rev 2016;39:419\u201327. https:\/\/doi.org\/10.1007\/s10143-016-0703-1.","DOI":"10.1007\/s10143-016-0703-1"},{"key":"2021050422002306787_j_iss-2019-1004_ref_019_w2aab3b7c27b1b6b1ab2b1c19Aa","doi-asserted-by":"crossref","unstructured":"Campos, F, Fujio, S, Sugata, S, Tokimura, H, Hanaya, R, Bohara, M, et\u00a0al. Effect of thrombin concentration on the adhesion strength and clinical application of fibrin glue-soaked sponge. Neurol Med Chir (Tokyo) 2013;53:17\u201320. https:\/\/doi.org\/10.2176\/nmc.53.17.","DOI":"10.2176\/nmc.53.17"},{"key":"2021050422002306787_j_iss-2019-1004_ref_020_w2aab3b7c27b1b6b1ab2b1c20Aa","doi-asserted-by":"crossref","unstructured":"Kim, EH, Ahn, JY, Kim, SH. Technique and outcome of endoscopy-assisted microscopic extended transsphenoidal surgery for suprasellar craniopharyngiomas. J Neurosurg 2011;114:1338\u201349. https:\/\/doi.org\/10.3171\/2010.11.jns10612.","DOI":"10.3171\/2010.11.JNS10612"},{"key":"2021050422002306787_j_iss-2019-1004_ref_021_w2aab3b7c27b1b6b1ab2b1c21Aa","doi-asserted-by":"crossref","unstructured":"Yang, I, Sughrue, ME, Rutkowski, MJ, Kaur, R, Ivan, ME, Aranda, D, et\u00a0al. Craniopharyngioma: a comparison of tumor control with various treatment strategies. Neurosurg Focus 2010;28:E5. https:\/\/doi.org\/10.3171\/2010.1.focus09307.","DOI":"10.3171\/2010.1.FOCUS09307"},{"key":"2021050422002306787_j_iss-2019-1004_ref_022_w2aab3b7c27b1b6b1ab2b1c22Aa","doi-asserted-by":"crossref","unstructured":"Xu, Z, Yen, CP, Schlesinger, D, Sheehan, J. Outcomes of Gamma Knife surgery for craniopharyngiomas. J Neuro Oncol 2011;104:305\u201313. https:\/\/doi.org\/10.1007\/s11060-010-0494-0.","DOI":"10.1007\/s11060-010-0494-0"},{"key":"2021050422002306787_j_iss-2019-1004_ref_023_w2aab3b7c27b1b6b1ab2b1c23Aa","doi-asserted-by":"crossref","unstructured":"Lee, CC, Yang, HC, Chen, CJ, Hung, YC, Wu, HM, Shiau, CY, et\u00a0al. Gamma Knife surgery for craniopharyngioma: report on a 20-year experience. J Neurosurg 2014;121:167\u201378. https:\/\/doi.org\/10.3171\/2014.8.gks141411.","DOI":"10.3171\/2014.8.GKS141411"},{"key":"2021050422002306787_j_iss-2019-1004_ref_024_w2aab3b7c27b1b6b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Losa, M, Pieri, V, Bailo, M, Gagliardi, F, Barzaghi, LR, Gioia, L, et\u00a0al. Single fraction and multisession Gamma Knife radiosurgery for craniopharyngioma. Pituitary 2018;21:499\u2013506. https:\/\/doi.org\/10.1007\/s11102-018-0903-5.","DOI":"10.1007\/s11102-018-0903-5"},{"key":"2021050422002306787_j_iss-2019-1004_ref_025_w2aab3b7c27b1b6b1ab2b1c25Aa","doi-asserted-by":"crossref","unstructured":"Jee, TK, Seol, HJ, Im, YS, Kong, DS, Nam, DH, Park, K, et\u00a0al. Fractionated Gamma Knife radiosurgery for benign perioptic tumors: outcomes of 38 patients in a single institute. Brain Tumor Res Treat 2014;2:56\u201361. https:\/\/doi.org\/10.14791\/btrt.2014.2.2.56.","DOI":"10.14791\/btrt.2014.2.2.56"},{"key":"2021050422002306787_j_iss-2019-1004_ref_026_w2aab3b7c27b1b6b1ab2b1c26Aa","doi-asserted-by":"crossref","unstructured":"Brastianos, PK, Taylor-Weiner, A, Manley, PE, Jones, RT, Dias-Santagata, D, Thorner, AR, et\u00a0al. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet 2014;46:161\u20135. https:\/\/doi.org\/10.1038\/ng.2868.","DOI":"10.1038\/ng.2868"},{"key":"2021050422002306787_j_iss-2019-1004_ref_027_w2aab3b7c27b1b6b1ab2b1c27Aa","doi-asserted-by":"crossref","unstructured":"Yoshimoto, K, Hatae, R, Suzuki, SO, Hata, N, Kuga, D, Akagi, Y, et\u00a0al. High-resolution melting and immunohistochemical analysis efficiently detects mutually exclusive genetic alterations of adamantinomatous and papillary craniopharyngiomas. Neuropathology 2018;38:3\u201310. https:\/\/doi.org\/10.1111\/neup.12408.","DOI":"10.1111\/neup.12408"},{"key":"2021050422002306787_j_iss-2019-1004_ref_028_w2aab3b7c27b1b6b1ab2b1c28Aa","doi-asserted-by":"crossref","unstructured":"Brastianos, PK, Shankar, GM, Gill, CM, Taylor-Weiner, A, Nayyar, N, Panka, DJ, et\u00a0al. Dramatic response of BRAF V600E mutant papillary craniopharyngioma to targeted therapy. J Natl Cancer Inst 2015;108. pii: djv310. https:\/\/doi.org\/10.1093\/jnci\/djv310.","DOI":"10.1093\/jnci\/djv310"},{"key":"2021050422002306787_j_iss-2019-1004_ref_029_w2aab3b7c27b1b6b1ab2b1c29Aa","doi-asserted-by":"crossref","unstructured":"Roque, A, Odia, Y. BRAF-V600E mutant papillary craniopharyngioma dramatically responds to combination BRAF and MEK inhibitors. CNS Oncol 2017;6:95\u20139. https:\/\/doi.org\/10.2217\/cns-2016-0034.","DOI":"10.2217\/cns-2016-0034"},{"key":"2021050422002306787_j_iss-2019-1004_ref_030_w2aab3b7c27b1b6b1ab2b1c30Aa","doi-asserted-by":"crossref","unstructured":"Rostami, E, Witt Nystr\u00f6m, P, Libard, S, Wikstr\u00f6m, J, Casar-Borota, O, Gudjonsson, O. Recurrent papillary craniopharyngioma with BRAFV600E mutation treated with neoadjuvant-targeted therapy. Acta Neurochir 2017;159:2217\u201321. https:\/\/doi.org\/10.1007\/s00701-017-3311-0.","DOI":"10.1007\/s00701-017-3311-0"},{"key":"2021050422002306787_j_iss-2019-1004_ref_031_w2aab3b7c27b1b6b1ab2b1c31Aa","doi-asserted-by":"crossref","unstructured":"Juratli, TA, Jones, PS, Wang, N, Subramanian, M, Aylwin, SJB, Odia, Y, et\u00a0al. Targeted treatment of papillary craniopharyngiomas harboring BRAF V600E mutations. Cancer 2019;125:2910\u20134. https:\/\/doi.org\/10.1002\/cncr.32197.","DOI":"10.1002\/cncr.32197"},{"key":"2021050422002306787_j_iss-2019-1004_ref_032_w2aab3b7c27b1b6b1ab2b1c32Aa","doi-asserted-by":"crossref","unstructured":"Yue, Q, Yu, Y, Shi, Z, Wang, Y, Zhu, W, Du, Z, et\u00a0al. Prediction of BRAF mutation status of craniopharyngioma using magnetic resonance imaging features. J Neurosurg 2018;129:27\u201334. https:\/\/doi.org\/10.3171\/2017.4.jns163113.","DOI":"10.3171\/2017.4.JNS163113"},{"key":"2021050422002306787_j_iss-2019-1004_ref_033_w2aab3b7c27b1b6b1ab2b1c33Aa","doi-asserted-by":"crossref","unstructured":"Fujio, S, Juratli, TA, Arita, K, Hirano, H, Nagano, Y, Takajo, T, et\u00a0al. A clinical rule for preoperative prediction of BRAF mutation status in craniopharyngiomas. Neurosurgery 2019;85:204\u201310. https:\/\/doi.org\/10.1093\/neuros\/nyy569.","DOI":"10.1093\/neuros\/nyz327"}],"container-title":["Innovative Surgical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/iss\/ahead-of-print\/article-10.1515-iss-2019-1004\/article-10.1515-iss-2019-1004.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/iss-2019-1004\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/iss-2019-1004\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T22:15:43Z","timestamp":1620166543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/iss-2019-1004\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,4,7]]},"published-print":{"date-parts":[[2021,5,3]]}},"alternative-id":["10.1515\/iss-2019-1004"],"URL":"https:\/\/doi.org\/10.1515\/iss-2019-1004","relation":{},"ISSN":["2364-7485"],"issn-type":[{"value":"2364-7485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,30]]}}}