{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:09:33Z","timestamp":1787022573008,"version":"build-2736575974"},"reference-count":51,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_iss-2020-0019_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Indocyanine green (ICG) is a fluorescent dye which was initially used for liver functional assessment. Moreover, it is of value for intraoperative visualization of liver segments and bile ducts or primary and secondary liver tumors. Especially in minimally invasive liver surgery, this is essential to enhance the precision of anatomical guided surgery and oncological quality. As early adopters of ICG implementation into laparoscopic and robotic-assisted liver surgery in Germany, we summarize the current recommendations and share our experiences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_iss-2020-0019_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Actual strategies for ICG application in minimally invasive liver surgery were evaluated and summarized during a review of the literature. Experiences in patients who underwent laparoscopic or robotic-assisted liver surgery with intraoperative ICG staining between 2018 and 2020 from the Magdeburg registry for minimally invasive liver surgery (MD-MILS) were evaluated and the data were analyzed retrospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_iss-2020-0019_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ICG can be used to identify anatomical liver segments by fluorescence angiography via direct or indirect tissue staining. Fluorescence cholangiography visualizes the intra- and extrahepatic bile ducts. Primary and secondary liver tumors can be identified with a sensitivity of 69\u2013100%. For this 0.5\u00a0mg\/kg body weight ICG must be applicated intravenously 2\u201314\u00a0days prior to surgery. Within the MD-MILS we identified 18 patients which received ICG for intraoperative tumor staining of hepatocellular carcinoma (HCC), cholangiocarcinoma, peritoneal HCC metastases, adenoma, or colorectal liver metastases. The sensitivity for tumor staining was 100%. In 27.8% additional liver tumors were identified by ICG fluorescence. In 39% a false positive signal could be detected. This occurred mainly in cirrhotic livers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_iss-2020-0019_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ICG staining is a simple and useful tool to assess individual hepatic anatomy or to detect tumors during minimally invasive liver surgery. It may enhance surgical precision and improve oncological quality. False-positive detection rates of liver tumors can be reduced by respecting the tumor entity and liver functional impairments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/iss-2020-0019","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T11:33:55Z","timestamp":1619177635000},"page":"59-66","source":"Crossref","is-referenced-by-count":20,"title":["Tumor visualization and fluorescence angiography with indocyanine green (ICG) in laparoscopic and robotic hepatobiliary surgery\u00a0\u2013 valuation of early adopters from Germany"],"prefix":"10.1515","volume":"6","author":[{"given":"Mareike","family":"Franz","sequence":"first","affiliation":[{"name":"Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Arend","sequence":"additional","affiliation":[{"name":"Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotelis","family":"Perrakis","sequence":"additional","affiliation":[{"name":"Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirhasan","family":"Rahimli","sequence":"additional","affiliation":[{"name":"Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor-Radu","family":"Negrini","sequence":"additional","affiliation":[{"name":"Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Stockheim","sequence":"additional","affiliation":[{"name":"Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Croner","sequence":"additional","affiliation":[{"name":"Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"2023010209162819113_j_iss-2020-0019_ref_001","doi-asserted-by":"crossref","unstructured":"Huang, S-W, Ou, J-J, Wong, HP. 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