{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:05:53Z","timestamp":1789974353576,"version":"4.0.1"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Innovation Focus Regenerative Surgery of the University Hospital Basel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_iss-2025-0010_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Orbital lymphatic-venous malformations (LVMs) are rare congenital anomalies that can cause\u00a0significant functional and aesthetic impairments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_iss-2025-0010_abs_002\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This case report details\u00a0the comprehensive treatment of a 47-year-old male with a longstanding orbital combined slow-flow vascular malformation. Diagnostic evaluation included magnetic resonance imaging and a sonographically guided core needle biopsy, which confirmed a benign lymphatic-venous malformation. The treatment started with minimally invasive sclerotherapy to reduce lesion size, followed by surgical debulking to alleviate proptosis and mechanical restrictions. Finally, reconstructive surgery addressed residual eyelid deformities, including ectropion and ptosis. Post-treatment outcomes demonstrated stable visual function, improved eyelid position, and a significant enhancement in the patient\u2019s aesthetic appearance and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_iss-2025-0010_abs_003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The staged, multimodal approach underscores the importance of individualized treatment planning and interdisciplinary collaboration. This case highlights the potential for excellent functional and aesthetic outcomes in the management of complex orbital LVMs when nonsurgical and surgical techniques are strategically combined.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/iss-2025-0010","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T05:01:28Z","timestamp":1751000488000},"page":"177-182","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive interdisciplinary treatment of an orbital lymphatic-venous malformation: a case report"],"prefix":"10.1515","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2809-4067","authenticated-orcid":false,"given":"C\u00e9line","family":"Tourbier","sequence":"first","affiliation":[{"name":"30262 Clinic of Oral and Cranio-Maxillofacial Surgery, University Hospital Basel , Basel , Switzerland"},{"name":"Department of Biomedical Engineering , Medical Additive Manufacturing Research Group (Swiss MAM), University of Basel , Allschwil , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-1195","authenticated-orcid":false,"given":"Bilal","family":"Msallem","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering , Medical Additive Manufacturing Research Group (Swiss MAM), University of Basel , Allschwil , Switzerland"},{"name":"University Center for Orthopedics, Trauma and Plastic Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden , Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1933-5131","authenticated-orcid":false,"given":"Martin Thanh-Long","family":"Takes","sequence":"additional","affiliation":[{"name":"Medizinisch Radiologisches Institut Z\u00fcrich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-9308","authenticated-orcid":false,"given":"Florian M.","family":"Thieringer","sequence":"additional","affiliation":[{"name":"30262 Clinic of Oral and Cranio-Maxillofacial Surgery, University Hospital Basel , Basel , Switzerland"},{"name":"Department of Biomedical Engineering , Medical Additive Manufacturing Research Group (Swiss MAM), University of Basel , Allschwil , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-9961","authenticated-orcid":false,"given":"Lukas B.","family":"Seifert","sequence":"additional","affiliation":[{"name":"30262 Clinic of Oral and Cranio-Maxillofacial Surgery, University Hospital Basel , Basel , Switzerland"},{"name":"Department of Biomedical Engineering , Medical Additive Manufacturing Research Group (Swiss MAM), University of Basel , Allschwil , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"2026092106573232098_j_iss-2025-0010_ref_001","unstructured":"Orbital lymphaticovenous malformations: current and future treatments\u00a0\u2013\u00a0ScienceDirect. [cited 2024 Nov 10]. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0039625715000405?via%3Dihub."},{"key":"2026092106573232098_j_iss-2025-0010_ref_002","doi-asserted-by":"crossref","unstructured":"Greene, AK, Alomari, AI. Management of venous malformations. Clin Plast Surg 2011;38:83\u201393. https:\/\/doi.org\/10.1016\/j.cps.2010.08.003.","DOI":"10.1016\/j.cps.2010.08.003"},{"key":"2026092106573232098_j_iss-2025-0010_ref_003","doi-asserted-by":"crossref","unstructured":"Colafati, GS, Piccirilli, E, Marrazzo, A, Carboni, A, Diociaiuti, A, El Hachem, M, et al.. Vascular lesions of the pediatric orbit: a radiological walkthrough.\u00a0Front Pediatr 2022;10. https:\/\/doi.org\/10.3389\/fped.2022.734286.","DOI":"10.3389\/fped.2022.734286"},{"key":"2026092106573232098_j_iss-2025-0010_ref_004","doi-asserted-by":"crossref","unstructured":"Elluru, RG, Balakrishnan, K, Padua, HM. Lymphatic malformations: diagnosis and management. Semin Pediatr Surg 2014;23:178\u201385. https:\/\/doi.org\/10.1053\/j.sempedsurg.2014.07.002.","DOI":"10.1053\/j.sempedsurg.2014.07.002"},{"key":"2026092106573232098_j_iss-2025-0010_ref_005","doi-asserted-by":"crossref","unstructured":"Nassiri, N, Rootman, J, Rootman, DB, Goldberg, RA. Orbital lymphaticovenous malformations: current and future treatments. Surv Ophthalmol 2015;60:383\u2013405. https:\/\/doi.org\/10.1016\/j.survophthal.2015.03.001.","DOI":"10.1016\/j.survophthal.2015.03.001"},{"key":"2026092106573232098_j_iss-2025-0010_ref_006","doi-asserted-by":"crossref","unstructured":"Colletti, G, Biglioli, F, Poli, T, Dessy, M, Cucurullo, M, Petrillo, M, et al.. Vascular malformations of the orbit (lymphatic, venous, arteriovenous): diagnosis, management and results. J\u00a0Craniomaxillofac Surg 2019;47:726\u201340. https:\/\/doi.org\/10.1016\/j.jcms.2018.09.009.","DOI":"10.1016\/j.jcms.2018.09.009"},{"key":"2026092106573232098_j_iss-2025-0010_ref_007","doi-asserted-by":"crossref","unstructured":"De, ML, De Sanctis, P, Tollefson, M, Mardini, S, Garrity, JA, Morris, PP, et al.. Sclerotherapy for low-flow vascular malformations of the orbital and periocular regions: systematic review and meta-analysis. Surv Ophthalmol 2020;65:41\u20137.","DOI":"10.1016\/j.survophthal.2019.08.003"},{"key":"2026092106573232098_j_iss-2025-0010_ref_008","doi-asserted-by":"crossref","unstructured":"Horbach, SE, Lokhorst, MM, Saeed, P, Rothov\u00e1, A, van der Horst, CM. Sclerotherapy for low-flow vascular malformations of the head and neck: a systematic review of sclerosing agents. J\u00a0Plast Reconstr Aesthetic Surg 2016;69:295\u2013304. https:\/\/doi.org\/10.1016\/j.bjps.2015.10.045.","DOI":"10.1016\/j.bjps.2015.10.045"},{"key":"2026092106573232098_j_iss-2025-0010_ref_009","doi-asserted-by":"crossref","unstructured":"Schmitt, N, Lorenz, J, Hohenstatt, S, Semmelmayer, K, Ruping, F, Hoffmann, J, et al.. Sclerotherapy of venous malformations using polidocanol: effectiveness, safety, and predictors of outcomes and adverse events. J\u00a0Vasc Intervent Radiol 2023;34:2103\u20139. https:\/\/doi.org\/10.1016\/j.jvir.2023.08.032.","DOI":"10.1016\/j.jvir.2023.08.032"},{"key":"2026092106573232098_j_iss-2025-0010_ref_010","doi-asserted-by":"crossref","unstructured":"Guzelbey, T, Cingoz, M, Erdim, C, Mutlu, IN, K\u0131l\u0131ckesmez, O. Effectiveness of polidocanol sclerotherapy in alleviating symptoms in patients with venous malformations. J\u00a0Vasc Surg Venous Lymphat Disord 2024;12. https:\/\/doi.org\/10.1016\/j.jvsv.2023.101698.","DOI":"10.1016\/j.jvsv.2023.101698"},{"key":"2026092106573232098_j_iss-2025-0010_ref_011","doi-asserted-by":"crossref","unstructured":"Lokdarshi, G, Kumar, S, Kumar, S, Nitu, N, Gaur, N. Image-guided percutaneous sclerotherapy for orbital low-flow malformation: our experience. Indian J Radiol Imag 2024;34:539\u201344. https:\/\/doi.org\/10.1055\/s-0044-1779689.","DOI":"10.1055\/s-0044-1779689"},{"key":"2026092106573232098_j_iss-2025-0010_ref_012","doi-asserted-by":"crossref","unstructured":"Dompmartin, A, Blaizot, X, Th\u00e9ron, J, Hammer, F, Chene, Y, Labb\u00e9, D, et al.. Radio-opaque ethylcellulose-ethanol is a safe and efficient sclerosing agent for venous malformations. Eur Radiol 2011;21:2647\u201356. https:\/\/doi.org\/10.1007\/s00330-011-2213-4.","DOI":"10.1007\/s00330-011-2213-4"},{"key":"2026092106573232098_j_iss-2025-0010_ref_013","doi-asserted-by":"crossref","unstructured":"Berthout, A, Jacomet, PV, Putterman, M, Galatoire, O, Morax, S. Traitement chirurgical des lymphangiomes orbitaires diffus de l\u2019adulte : \u00e0 propos de deux cas. J\u00a0Fran\u00e7ais d\u2019Ophtalmol 2008;31:1006\u201317. https:\/\/doi.org\/10.1016\/s0181-5512(08)74748-x.","DOI":"10.1016\/S0181-5512(08)74748-X"}],"container-title":["Innovative Surgical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/iss-2025-0010\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/iss-2025-0010\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:58:31Z","timestamp":1789973911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/iss-2025-0010\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":13,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,8,5]]},"published-print":{"date-parts":[[2026,9,21]]}},"alternative-id":["10.1515\/iss-2025-0010"],"URL":"https:\/\/doi.org\/10.1515\/iss-2025-0010","relation":{},"ISSN":["2364-7485"],"issn-type":[{"value":"2364-7485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}