{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:45:28Z","timestamp":1765539928826,"version":"3.48.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The pathophysiological responses to immune stress (IS) include activation of several processes which are dependent on cytosolic Ca2+ elevation. Magnesium frequently acts as a natural Ca2+ antagonist. In this study we have observed that Mg2 + can protect guinea-pigs against IS. Antigen-sensitized guinea-pigs, which had been fed a magnesiumdeficient diet, were given a single dose (15 mg) of MgCl2 intraperitoneally 1 h before antigen challenge. The development of anaphylactic shock (AS) was observed during the next 2 h, and the hearts were subsequently examined histologically for signs of cardiac myolysis (CM). Magnesium (i) reduced the incidence of CM from 40% to 10% (p&lt;0.05); (ii) reduced the incidence of AS from 61% to 35% (p&lt;0.05); (iii) attenuated the severity of the AS; and (iv) lowered mortality from 39% in the control to 19% in the Mg2+-treated group (p=0.1). Serum and tissue total [Mg2+] were not affected by the administration of MgCl2. Also, the serum and heart Mg2+ levels were the same whether or not the guinea-pigs developed AS or CM. In cell culture we demonstrated that by elevating the [Mg2+] in the medium bathing sensitized rat basophilic leukemia (RBL) cells, the increase in cytosolic [Ca2+] subsequent to antigen challenge was reduced from 174 \u00b1 23.28% (1 mM) to 82.74 \u00b1 13.22 % (3 mM). We conclude that a single treatment with Mg2+ can considerably diminish damage induced by immune stress, probably by its altering the Ca2+: Mg2+ratio. Since the physiological reaction to different types of stress is similar, Mg2 + could prove beneficial in preventing stress-induced shock in general. Studies examining the mechanisms by which Mg2 + exerts its effects thus provide a scientific basis for the current clinical use of Mg2 + in acute myocardial infarction (AMI) and asthma.<\/jats:p>","DOI":"10.1515\/jbcpp-1994-050104","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T05:07:21Z","timestamp":1744693641000},"page":"45-58","source":"Crossref","is-referenced-by-count":2,"title":["Magnesium Protects Against Anaphylactic Shock and Cardiac Myolysis in Guinea-Pigs"],"prefix":"10.1515","volume":"5","author":[{"given":"Fabio","family":"Kusniec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben-Ami","family":"Sela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaakov","family":"Ashkenazy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Fiegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Moshonov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uriel","family":"Zor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,10]]},"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-1994-050104\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-1994-050104\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:40:41Z","timestamp":1765539641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-1994-050104\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,4,10]]},"published-print":{"date-parts":[[1994,1,1]]}},"alternative-id":["10.1515\/jbcpp-1994-050104"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-1994-050104","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"type":"electronic","value":"2191-0286"},{"type":"print","value":"0792-6855"}],"subject":[],"published":{"date-parts":[[1994,1,1]]}}}