{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:24:06Z","timestamp":1765545846737,"version":"3.48.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:bold>\n Strophanthus hispidus<\/jats:italic>\n DC (Apocynaceae) is a medicinal plant widely used in traditional African medicine in the treatment of rheumatic afflictions, ulcer, conjunctivitis, leprosy and skin diseases. This study sought to investigate the antinociceptive, anti-inflammatory and antiulcer properties of the ethanol root extract of\n S. hispidus.<\/jats:italic>\n <\/jats:p>\n \n Methods:<\/jats:bold>\n Antinociceptive activity was evaluated using acetic acid-induced writhing and formalin tests in mice. The carrageenan- and egg albumin-induced rat paw edema tests were used to investigate the anti-inflammatory actions, whereas the antiulcer activity was investigated using ethanol-, HCl- and pyloric ligation-induced gastric ulcer models in rats.\n <\/jats:p>\n \n Results:<\/jats:bold>\n S. hispidus<\/jats:italic>\n [100\u2013800 mg\/kg orally (po)] produced significant (p<0.05) inhibition of writhing reflex with peak effect of 74.13% inhibition observed at 800 mg\/kg. Similarly,\n S. hispidus<\/jats:italic>\n significantly (p<0.05) attenuated formalin-induced early and late phase of nociception with peak effect of 61.84% and 89.43%, respectively, at 200 mg\/kg.\n S. hispidus<\/jats:italic>\n (25\u2013800 mg\/kg po) caused significant (p<0.05) inhibition of edema development in the carrageenan and egg albumin models with peak effect (93.40% and 90.10% inhibition of edema formation) observed at 50 mg\/kg. With respect to antiulcer activity,\n S. hispidus<\/jats:italic>\n (100\u2013800 mg\/kg) showed potent antiulcer activity with respective peak effects of 96% (ethanol-induced), 99% (HCl-induced) and 70.60% inhibition of ulcer.\n <\/jats:p>\n \n Conclusions<\/jats:bold>\n : The findings in this study suggest that the ethanol root extract of\n S. hispidus<\/jats:italic>\n possesses antinociceptive, anti-inflammatory and antiulcerogenic activities. This justifies the use of the extract in folklore medicine for the treatment of ulcer and inflammatory disorders.\n <\/jats:p>","DOI":"10.1515\/jbcpp-2013-0005","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T16:09:41Z","timestamp":1369930181000},"page":"277-286","source":"Crossref","is-referenced-by-count":9,"title":["Antinociceptive, anti-inflammatory and antiulcerogenic activities of ethanol root extract of\n Strophanthus hispidus<\/i>\n DC (Apocynaceae)"],"prefix":"10.1515","volume":"24","author":[{"given":"Ismail O.","family":"Ishola","sequence":"first","affiliation":[{"name":"Faculty of Basic Medical Sciences, Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufunsho","family":"Awodele","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences, Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim A.","family":"Oreagba","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences, Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulahi A.","family":"Murtala","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences, Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micah C.","family":"Chijioke","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences, Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2013,5,9]]},"container-title":["jbcpp"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0005\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0005\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:56:07Z","timestamp":1765540567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0005\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,9]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,13]]},"published-print":{"date-parts":[[2013,11,1]]}},"alternative-id":["10.1515\/jbcpp-2013-0005"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2013-0005","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"type":"electronic","value":"2191-0286"},{"type":"print","value":"0792-6855"}],"subject":[],"published":{"date-parts":[[2013,5,9]]}}}