{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:01:06Z","timestamp":1787238066815,"version":"build-2736575974"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : The effect of\n                    <jats:italic>Tridax procumbens<\/jats:italic>\n                    aqueous ethanolic extract on the rat corpus cavernosum smooth muscles was evaluated in the present study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method:<\/jats:bold>\n                    Corpus cavernosum strips obtained from healthy, young, adult male Wistar albino rats (250\u2013300 g) were precontracted with phenylephrine (10\n                    <jats:sup>\u20137<\/jats:sup>\n                    M) or KCl (60 mM) and then treated with various concentrations of\n                    <jats:italic>T. procumbens<\/jats:italic>\n                    extract (0.15\u20131.05 mg\/mL). The change in corpus cavernosum strip tension was recorded. The interactions between\n                    <jats:italic>T. procumbens<\/jats:italic>\n                    extract with acetylcholine and with sodium nitroprusside were also evaluated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The results indicated that corpus cavernosum strips relaxation induced by\n                    <jats:italic>T<\/jats:italic>\n                    .\n                    <jats:italic>procumbens<\/jats:italic>\n                    extract was concentration-dependent and this was significant (p&lt;0.5). Pre-treatment with a nitric oxide synthase (NOS) inhibitor (N\n                    <jats:sub>(1)<\/jats:sub>\n                    nitro-L-arginine-methyl ester, l-NAME), did not completely inhibit the relaxation. However,\n                    <jats:italic>T. procumbens<\/jats:italic>\n                    extract (0.6 mg\/mL) significantly (p&lt;0.5) enhanced both acetylcholine- and sodium nitroprusside-induced corpus cavernosum strips relaxation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Results suggest that\n                    <jats:italic>T. procumbens<\/jats:italic>\n                    extract has a concentration-dependent relaxant effect on the isolated rat corpus cavernosum. The mechanism of action of\n                    <jats:italic>T. procumbens<\/jats:italic>\n                    extract is complex. A part of its relaxing effect is mediated directly by the release of NO from endothelium which may improve erectile dysfunction.\n                  <\/jats:p>","DOI":"10.1515\/jbcpp-2013-0032","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T16:10:57Z","timestamp":1401898257000},"page":"211-216","source":"Crossref","is-referenced-by-count":7,"title":["The relaxant actions of ethanolic extract of\n                    <i>Tridax procumbens<\/i>\n                    (Linn.) on rat corpus cavernosum smooth muscle contraction"],"prefix":"10.1515","volume":"26","author":[{"given":"Hussein M.","family":"Salahdeen","sequence":"first","affiliation":[{"name":"Department of Physiology, Cardiovascular and Smooth Muscles Unit, Lagos State University, College of Medicine, P.M.B 21266, Ikeja, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gbolahan O.","family":"Idowu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Olabisi Onabanjo University, Ogun State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omoniyi K.","family":"Yemitan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Medicine, Lagos State University, Ikeja, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babatunde A.","family":"Murtala","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, Lagos State University, Ikeja, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rasak A.","family":"Alada","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,6,4]]},"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0032\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0032\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:42:55Z","timestamp":1765539775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0032\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,6,4]]},"published-print":{"date-parts":[[2015,3,1]]}},"alternative-id":["10.1515\/jbcpp-2013-0032"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2013-0032","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"value":"2191-0286","type":"electronic"},{"value":"0792-6855","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6,4]]}}}