{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:15:16Z","timestamp":1770984916133,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The use of traditional medicinal plants to treat various diseases is common in Sub-Saharan African countries, including Cameroon.\n                    <jats:italic>Millettia macrophylla<\/jats:italic>\n                    , one of such plants, was previously found to exhibit estrogenic properties in female Wistar rats. However, its effects on the male reproductive system are unknown. Based on literature evidence that phytoestrogens impair male sexual behavior, we aimed at assessing the effect of the extracts of\n                    <jats:italic>M. macrophylla<\/jats:italic>\n                    stem bark on the male reproductive system of Wistar rats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods:<\/jats:bold>\n                    We evaluated the effects of the dichloromethane (DCM) and methanol (MeOH) soluble fractions of\n                    <jats:italic>M. macrophylla<\/jats:italic>\n                    stem bark on male rat sexual behavior, as well as androgen-dependent parameters for 60 days.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Data showed a significant decrease (p&lt;0.05) in the wiring-touch frequency, mount frequency, intromission frequency, ejaculatory frequency, penile-licking frequency, and computed indices of sexual behavior, throughout the experimental period, as well as a significant increase (p&lt;0.001) in mount, intromission, and ejaculatory latencies as well as post-ejaculatory interval. Moreover, we observed a significant decrease (p&lt;0.05) in the androgen-dependent sexual parameters evaluated. The DCM extract did not induce significant effects on the assessed parameters.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These results suggest that long-term exposure to the estrogenic MeOH fraction of\n                    <jats:italic>M. macrophylla<\/jats:italic>\n                    stem bark negatively alters sexual behavior and spermatogenesis.\n                  <\/jats:p>","DOI":"10.1515\/jbcpp-2013-0136","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T16:11:38Z","timestamp":1395850298000},"page":"53-64","source":"Crossref","is-referenced-by-count":5,"title":["The methanol-soluble fraction of\n                    <i>Millettia macrophylla<\/i>\n                    (Fabaceae) stem bark endowed with estrogenic properties has adverse effects on the male reproductive system of Wistar rats"],"prefix":"10.1515","volume":"26","author":[{"given":"St\u00e9phane","family":"Zingue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal Beatrice Magne","family":"Nde","sequence":"additional","affiliation":[{"name":"Prince Henry\u2019s Institute of Medical Research, Monash Medical Centre, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieudonn\u00e9","family":"Njamen","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Yaounde, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,3,26]]},"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0136\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0136\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:24:54Z","timestamp":1765542294000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0136\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,26]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,4,21]]},"published-print":{"date-parts":[[2015,1,1]]}},"alternative-id":["10.1515\/jbcpp-2013-0136"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2013-0136","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"value":"2191-0286","type":"electronic"},{"value":"0792-6855","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3,26]]}}}