{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:48:44Z","timestamp":1781660924273,"version":"3.54.5"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    This work was designed to investigate the modulatory effects of cod liver oil on the acute exposure to carbon tetrachloride (CCL\n                    <jats:sub>4<\/jats:sub>\n                    ) in experimental animal models.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Markers of oxidative stress, enzymic and non-enzymic antioxidants were assessed in the liver and kidney.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The results showed significant (p&lt;0.05) increase in the total protein of the kidney of rats pretreated with cod liver oil compared to the control and CCL\n                    <jats:sub>4<\/jats:sub>\n                    -treated groups. Acute exposure to CCL\n                    <jats:sub>4<\/jats:sub>\n                    also significantly (p&lt;0.05) increased thiobarbituric acid reactive substances in the liver of rats treated with cod liver oil compared to the CCL\n                    <jats:sub>4<\/jats:sub>\n                    -treated rats. The reduced glutathione (GSH) content in the liver of the rats administered with CCL\n                    <jats:sub>4<\/jats:sub>\n                    decreased significantly compared to that in all other treatment groups, whereas rats pretreated and co-administered with cod liver oil and CCl\n                    <jats:sub>4<\/jats:sub>\n                    showed significant (p&lt;0.05) improvement in the liver GSH content. The catalase (CAT) activity in the liver of rats exposed to CCL\n                    <jats:sub>4<\/jats:sub>\n                    decreased (p&lt;0.05) significantly, whereas the activity increased (p&lt;0.05) significantly in the rats that were treated with cod liver oil compared to the CCl\n                    <jats:sub>4<\/jats:sub>\n                    only-treated group. The percentage inhibition of superoxide dismutase (SOD) increased (p&lt;0.05) significantly in the liver of rats administered cod liver oil compared to the CCL\n                    <jats:sub>4<\/jats:sub>\n                    -treated rats and the control.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Taken together, cod liver oil attenuates CCL\n                    <jats:sub>4<\/jats:sub>\n                    -induced toxicity and oxidative stress in the liver but not in the kidney of rats acutely exposed to CCL\n                    <jats:sub>4<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1515\/jbcpp-2013-0143","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T17:08:35Z","timestamp":1401728915000},"page":"253-257","source":"Crossref","is-referenced-by-count":1,"title":["Modulatory effects of cod liver oil on the antioxidant status and oxidative stress induced by acute exposure to carbon tetrachloride (CCL\n                    <sub>4<\/sub>\n                    ) in experimental animal models"],"prefix":"10.1515","volume":"26","author":[{"given":"Abam Esther","family":"Omugba","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences, Biochemistry Option, Bells University of Technology, Ota, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebayo J.","family":"Ajiboye","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Biochemistry Option, Bells University of Technology, Ota, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ademola A.","family":"Oyagbemi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan 200005, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eze","family":"Agofure","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Biochemistry Option, Bells University of Technology, Ota, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,5,29]]},"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0143\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0143\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:04:00Z","timestamp":1765541040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2013-0143\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,29]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,5,29]]},"published-print":{"date-parts":[[2015,5,1]]}},"alternative-id":["10.1515\/jbcpp-2013-0143"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2013-0143","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"value":"2191-0286","type":"electronic"},{"value":"0792-6855","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5,29]]}}}