{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T09:14:36Z","timestamp":1781946876404,"version":"3.54.5"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:bold>\n Adenia cissampeloides<\/jats:italic>\n (Planch ex. Hook) Harms (Passifloraceae) leaf infusion is used in traditional African medicine as a stimulant to treat depression and insanity. Thus, this study investigates antidepressant and anxiolytic activities of the hydroethanol leaf extract of\n Adenia cissampeloides<\/jats:italic>\n (ACE) in mice.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n ACE (50\u2013200 mg\/kg, p.o.) was administered to mice 1 h before behavioral studies; the forced swimming test (FST), tail suspension test (TST), elevated-plus maze test (EPM) hole-board test (HBT) and open field test (OFT). In addition, the probable mechanisms of antidepressant- and anxiolytic-like actions of ACE were also investigated.\n <\/jats:p>\n \n Results<\/jats:bold>\n : ACE (100 and 200 mg\/kg) produced significant (p<0.01) reduction in immobility, along with a significant increase in swimming activity (75.20%) and climbing (190.00%), respectively, similar to anti-immobility effect of imipramine in the FST. Also, in TST, ACE (100 and 200 mg\/kg) treatment significantly (p<0.01) reduced the immobility time by 35.60%, and 35.27%, respectively, which was similar to anti-immobility effect of fluoxetine (32.50%). However, the antidepressant-like effect produced by ACE was prevented (p<0.01) by yohimbine (\u03b1\n 2<\/jats:sub>\n -adrenoceptor antagonist), or sulpiride (dopamine D\n 2<\/jats:sub>\n receptor antagonist) pretreatment. ACE (50 and 100 mg\/kg) treatment (p<0.01) increased number (41.67%) and duration of head-dips (52.27%) in HBT. Similarly, ACE (50\u2013200 mg\/kg) increased duration of open arm entries (p<0.001) in EPM. However, this effect was reversed (p<0.001) by pretreatment of mice with cyproheptadine (5-HT\n 2<\/jats:sub>\n receptor antagonist) (60.87%).\n <\/jats:p>\n \n Conclusions<\/jats:bold>\n : Findings from these studies revealed antidepressant-like effect of ACE mediated through interaction with dopamine D\n 2-<\/jats:sub>\n receptor or \u03b1\n 2<\/jats:sub>\n -adrenoceptor. Also an anxiolytic-like effect through interaction with 5-HT\n 2<\/jats:sub>\n receptors.\n <\/jats:p>","DOI":"10.1515\/jbcpp-2014-0015","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T13:41:53Z","timestamp":1407505313000},"page":"301-312","source":"Crossref","is-referenced-by-count":4,"title":["Role for monoaminergic systems in the antidepressant and anxiolytic properties of the hydroethanolic leaf extract from\n Adenia cissampeloides<\/i>"],"prefix":"10.1515","volume":"26","author":[{"given":"Ismail O.","family":"Ishola","sequence":"first","affiliation":[{"name":"Faculty of Basic Medical Sciences, College of Medicine, Department of Pharmacology, Therapeutics and Toxicology, University of Lagos, PMB 12003 Surulere, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunday O.","family":"Olayemi","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences, College of Medicine, Department of Pharmacology, Therapeutics and Toxicology, University of Lagos, PMB 12003 Surulere, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omoniyi K.","family":"Yemitan","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences, Department of Pharmacology, Lagos State University College of Medicine, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolawole","family":"Akinseye","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences, College of Medicine, Department of Pharmacology, Therapeutics and Toxicology, University of Lagos, PMB 12003 Surulere, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,8,7]]},"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2014-0015\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2014-0015\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:04:01Z","timestamp":1765541041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2014-0015\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,7]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,5,29]]},"published-print":{"date-parts":[[2015,5,1]]}},"alternative-id":["10.1515\/jbcpp-2014-0015"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2014-0015","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"value":"2191-0286","type":"electronic"},{"value":"0792-6855","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8,7]]}}}