{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:43:29Z","timestamp":1791434609870,"version":"4.3.3"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To understand HIV pathogenesis or development is no simple undertaking and neither is the cell cycle which is highly complex that requires the coordination of multiple events and machinery. It is interesting that these two processes are interrelated, intersect and interact as HIV-1 infection results in cell cycle arrest at the G2 phase which is accompanied by massive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell death. For its own benefit, in an impressive manner and with the overabundance of tactics, HIV maneuvers DNA damage responses and cell cycle check points for viral replication at different stages from infection, to latency and to pathogenesis. Although the cell cycle is the most critical aspect involved in both viral and cellular replication, in this review, our main focus is on recent developments, including our own observations in the field of cell cycle proteins, checkpoints and strategies utilized by the viruses to manipulate these pathways to promote their own replication and survival. We will also discuss the emerging concept of targeting the replication initiation machinery for HIV therapy.\n                  <\/jats:p>","DOI":"10.1515\/jbcpp-2014-0018","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T16:10:16Z","timestamp":1405959016000},"page":"1-11","source":"Crossref","is-referenced-by-count":8,"title":["Cell cycle checkpoints and pathogenesis of HIV-1 infection: a brief overview"],"prefix":"10.1515","volume":"26","author":[{"given":"Kesava Rao V.","family":"Kurapati","sequence":"first","affiliation":[{"name":"Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Modesto A. Maidique Campus, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thangavel","family":"Samikkannu","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Modesto A. Maidique Campus, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Subba Rao","family":"Atluri","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Modesto A. Maidique Campus, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavan P.N.","family":"Nair","sequence":"additional","affiliation":[{"name":"Institute of Neuroimmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Modesto A. Maidique Campus, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,7,19]]},"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2014-0018\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2014-0018\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:24:55Z","timestamp":1765542295000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2014-0018\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,19]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,4,21]]},"published-print":{"date-parts":[[2015,1,1]]}},"alternative-id":["10.1515\/jbcpp-2014-0018"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2014-0018","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"value":"2191-0286","type":"electronic"},{"value":"0792-6855","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7,19]]}}}