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This study investigated the effects of phenytoin and amitriptyline on memory deficit associated with neuropathic pain.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Twenty-eight adult male Wistar rats were randomly divided into four groups: A, B, C, and D (n=7). Groups A, B, C, and D served as sham control, sciatic nerve ligated untreated, sciatic nerve ligated receiving amitriptyline (5 mg\/kg), and sciatic nerve ligated receiving phenytoin (10 mg\/kg) respectively. Treatments lasted for 14 days, after which both \u2018Y\u2019 maze and novel object recognition test (NOR) were performed. On the last day of treatment, the animals were anesthetized and their brain excised, and the prefrontal cortices and sciatic nerve were processed histologically using hematoxylin and eosin.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    There was memory impairment in the sciatic nerve ligated untreated group which was statistically significant (p&lt;0.05) when compared to the phenytoin-treated, amitriptyline-treated, and sham control groups using the \u2018Y\u2019 maze and NOR tests. Histological quantification showed that the prefrontal cortices of the ligated animals showed increased neural population in comparison to normal control. These increases were significantly marked in the untreated ligated group. Sciatic nerve of untreated ligated group showed high demyelination and axonal degeneration which was ameliorated in the treated animals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The administration of amitriptyline and phenytoin can ameliorate neuronal injury, demyelination, and memory impairment associated with neuropathic pain in Wistar rats.\n                  <\/jats:p>","DOI":"10.1515\/jbcpp-2014-0052","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T07:29:50Z","timestamp":1447399790000},"page":"101-108","source":"Crossref","is-referenced-by-count":8,"title":["Amitriptyline and phenytoin prevents memory deficit in sciatic nerve ligation model of neuropathic pain"],"prefix":"10.1515","volume":"27","author":[{"given":"Wahab Imam","family":"Abdulmajeed","sequence":"first","affiliation":[{"name":"Faculty of Basic Medical Sciences, Department of Physiology, University of Ilorin, Ilorin, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ridwan Babatunde","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Institute of Brain Sciences, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azeez Olakunle","family":"Ishola","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Afe-Babalola University Ado Ekiti, Ado Ekiti, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wasiu Gbolahan","family":"Balogun","sequence":"additional","affiliation":[{"name":"Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam Pulau Pinang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansa Emmanuel","family":"Cobham","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Afe-Babalola University Ado Ekiti, Ado Ekiti, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulbasit","family":"Amin","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences, Department of Physiology, University of Ilorin, Ilorin, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,11,13]]},"reference":[{"key":"2025121209120440470_j_jbcpp-2014-0052_ref_001_w2aab2b8b7b1b7b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Moriarty O, McGuire BE, Finn DP. 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