{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:57:09Z","timestamp":1789927029636,"version":"4.0.1"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Preclinical and clinical studies suggest the use of antioxidants as an effective measure to reduce the progression of oxidative-stress-related disorders. Nuclear factor E2-related factor 2 (Nrf2) is a key component to cellular redox homeostasis in the attenuation of oxidative-stress-associated pathological processes. The objective of the current study was to evaluate the role of geraniol (GOH) in preserving the plasma lipid status, endothelial function, antioxidant status, and inhibition of lipid peroxidation (LPO) in hamsters fed an atherogenic diet (AD).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Male Syrian hamsters were randomly grouped into four groups: group 1 was control animals; group 2 was animals fed GOH alone (100 mg\/kg bw po); group 3 was animals fed AD (standard pellet diet+10% coconut oil+0.25% cholesterol+0.25% cholic acid); and group 4 was fed AD+GOH (100 mg\/kg bw) for 12 weeks. At the end of the feeding period, the animals were sacrificed and the liver, heart, and aorta from each group were analyzed for antioxidants, LPO markers, and histological changes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    AD feeding induced a significant change in lipid profile, endothelial function marker, activities of the antioxidant enzymes, alterations in the LPO markers, Nrf2 expression, and equally significant changes in the organ histology.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Supplementation with GOH appreciably prevented the alterations induced by the AD on all the above parameters. Thus, GOH offers marked protection against AD-induced abnormalities.\n                  <\/jats:p>","DOI":"10.1515\/jbcpp-2014-0057","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T12:01:48Z","timestamp":1415275308000},"page":"335-346","source":"Crossref","is-referenced-by-count":38,"title":["Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis"],"prefix":"10.1515","volume":"26","author":[{"given":"Muthukumaran","family":"Jayachandran","sequence":"first","affiliation":[{"name":"Faculty of Science, Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaji","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Namasivayam","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamilnadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_001_w2aab2b8c38b1b7b1ab2ab1Aa","unstructured":"World Health Organization. Global atlas on cardiovascular disease prevention and control. http:\/\/www.Who.Int\/cardiovasculardiseases\/en\/. Accessed September 23, 2011."},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_002_w2aab2b8c38b1b7b1ab2ab2Aa","doi-asserted-by":"crossref","unstructured":"Edris AE. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review. Phytother Res 2007;21:308\u201323.10.1002\/ptr.2072","DOI":"10.1002\/ptr.2072"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_003_w2aab2b8c38b1b7b1ab2ab3Aa","unstructured":"Buhler DR, Miranda C. Antioxidant activities of flavonoids. Oregon: Oregon State University, 2000."},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_004_w2aab2b8c38b1b7b1ab2ab4Aa","doi-asserted-by":"crossref","unstructured":"Agbor GA, Oben JE, Ngogang JY, Xinxing C, Vinson JA. Antioxidant capacity of some herbs\/spices from Cameroon a comparative study of two methods. J Agric Food Chem 2005;53:6819\u201324.10.1021\/jf050445c","DOI":"10.1021\/jf050445c"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_005_w2aab2b8c38b1b7b1ab2ab5Aa","doi-asserted-by":"crossref","unstructured":"Vinson JA, Proch J, Bose P, Muchler S, Taffera P, Shuta D, et al. Chocolate is a powerful ex vivo and in vivo antioxidant, an antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American diets. J Agric Food Chem 2006;54:8071\u20136.10.1021\/jf062175j","DOI":"10.1021\/jf062175j"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_006_w2aab2b8c38b1b7b1ab2ab6Aa","doi-asserted-by":"crossref","unstructured":"Decorde K, Teissedre PL, Sutra T, Chardonnay T. Grape seed procyanidin extract supplementation prevents high diet induced obesity in hamsters by improving adipolane imbalance and oxidative stress markers. Mol Nutr Food Res 2009;53:659\u201366.10.1002\/mnfr.200800165","DOI":"10.1002\/mnfr.200800165"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_007_w2aab2b8c38b1b7b1ab2ab7Aa","doi-asserted-by":"crossref","unstructured":"Agbor GA, Vinson JA, Sortino J, Johnson R. Antioxidant and antiatherogenic activities of three GOH species on atherogenic diet fed hamsters. Exp Toxicol Pathol 2012;64:387\u201391.10.1016\/j.etp.2010.10.003","DOI":"10.1016\/j.etp.2010.10.003"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_008_w2aab2b8c38b1b7b1ab2ab8Aa","doi-asserted-by":"crossref","unstructured":"Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation 1993;88:2541\u20137.10.1161\/01.CIR.88.6.2541","DOI":"10.1161\/01.CIR.88.6.2541"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_009_w2aab2b8c38b1b7b1ab2ab9Aa","doi-asserted-by":"crossref","unstructured":"Slocum SL, Kensler TW. Nrf2: control of sensitivity to carcinogens. Arch Toxicol 2011;854:273\u201384.10.1007\/s00204-011-0675-4","DOI":"10.1007\/s00204-011-0675-4"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_010_w2aab2b8c38b1b7b1ab2ac10Aa","doi-asserted-by":"crossref","unstructured":"Shoff SM, Grummer M, Yatvin MB, Elson CE. Concentration-dependent increase of murine P388 and B16 population doubling time by the acyclic monoterpene GOH. Cancer Res 1991;51:37\u201342.10.1016\/0304-3835(90)90228-P","DOI":"10.1016\/0304-3835(90)90228-P"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_011_w2aab2b8c38b1b7b1ab2ac11Aa","doi-asserted-by":"crossref","unstructured":"Carnesecchi S, Schneider Y, Ceraline J, Duranton B, Gosse F, Seiler N, et al. GOH, a component of plant essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells. J Pharmacol Exp Ther 2001;298:197\u2013200.10.1016\/S0022-3565(24)29368-X","DOI":"10.1016\/S0022-3565(24)29368-X"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_012_w2aab2b8c38b1b7b1ab2ac12Aa","doi-asserted-by":"crossref","unstructured":"Carnesecchi S, Langley K, Exinger F, Gosse F, Raul F. GOH, a component of plant essential oils, sensitizes human colonic cancer cell to 5-fluorouracil treatment. J Pharmacol Exp Ther 2002;301:1\u20136.10.1124\/jpet.301.2.625","DOI":"10.1124\/jpet.301.2.625"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_013_w2aab2b8c38b1b7b1ab2ac13Aa","doi-asserted-by":"crossref","unstructured":"Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrite and nitrate in biological fluids. Anal Biochem 1982;126:131\u20138.10.1016\/0003-2697(82)90118-X","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_014_w2aab2b8c38b1b7b1ab2ac14Aa","doi-asserted-by":"crossref","unstructured":"Fraga CG, Leibouitz BE, Toppel AL. Lipid peroxidation measured as TBARS in tissue slices: characterization and comparison with homogenates and microsomes. Free Radic Biol Med 1988;4:155\u201361.10.1016\/0891-5849(88)90023-8","DOI":"10.1016\/0891-5849(88)90023-8"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_015_w2aab2b8c38b1b7b1ab2ac15Aa","doi-asserted-by":"crossref","unstructured":"Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low density lipoprotein. Anal Biochem 1993;202:384.10.1016\/0003-2697(92)90122-N","DOI":"10.1016\/0003-2697(92)90122-N"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_016_w2aab2b8c38b1b7b1ab2ac16Aa","doi-asserted-by":"crossref","unstructured":"Esterbauer H, Striegl G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 1989;6:67\u201375.10.3109\/10715768909073429","DOI":"10.3109\/10715768909073429"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_017_w2aab2b8c38b1b7b1ab2ac17Aa","doi-asserted-by":"crossref","unstructured":"Tiwari M, Kakkar P. Plant derived antioxidants \u2013 GOH and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. Toxicol In Vitro 1999;23:295\u2013301.10.1016\/j.tiv.2008.12.014","DOI":"10.1016\/j.tiv.2008.12.014"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_018_w2aab2b8c38b1b7b1ab2ac18Aa","doi-asserted-by":"crossref","unstructured":"Sun GY, Horrocks LA, Farooqui AA. The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases. J Neurochem 2007;103:1\u201316.10.1111\/j.1471-4159.2007.04670.x","DOI":"10.1111\/j.1471-4159.2007.04670.x"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_019_w2aab2b8c38b1b7b1ab2ac19Aa","doi-asserted-by":"crossref","unstructured":"Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972;47:389\u201394.10.1016\/0003-2697(72)90132-7","DOI":"10.1016\/0003-2697(72)90132-7"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_020_w2aab2b8c38b1b7b1ab2ac20Aa","doi-asserted-by":"crossref","unstructured":"Beers RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1952;195:133\u201340.10.1016\/S0021-9258(19)50881-X","DOI":"10.1016\/S0021-9258(19)50881-X"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_021_w2aab2b8c38b1b7b1ab2ac21Aa","doi-asserted-by":"crossref","unstructured":"Rotruck JT, Pope AL, Ganther H, Awanson AB, Hafeman DG, Hoeckstra WG. Selenium biochemical role as a component of glutathione peroxidase. Science 1973;179:588\u201390.10.1126\/science.179.4073.588","DOI":"10.1126\/science.179.4073.588"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_022_w2aab2b8c38b1b7b1ab2ac22Aa","doi-asserted-by":"crossref","unstructured":"Folhe L, Gunzler WA. Assays of glutathione peroxidase. Methods Enzymol 1984;105:114\u201321.10.1016\/S0076-6879(84)05015-1","DOI":"10.1016\/S0076-6879(84)05015-1"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_023_w2aab2b8c38b1b7b1ab2ac23Aa","doi-asserted-by":"crossref","unstructured":"Carlberg I, Mannervik B. Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione. Biochim Biophys Acta 1977;484:268\u201374.10.1016\/0005-2744(77)90083-3","DOI":"10.1016\/0005-2744(77)90083-3"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_024_w2aab2b8c38b1b7b1ab2ac24Aa","unstructured":"Gosselin RE, Hodge HC, Smith RP, Gleason MN. Clinical toxicology of commercial products, 4th ed. Baltimore: Williams and Wilkins, 1976:II\u2013168."},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_025_w2aab2b8c38b1b7b1ab2ac25Aa","doi-asserted-by":"crossref","unstructured":"Carroll JF, Dwyer TM, Grady AW, Reinhart GA, Montani JP, Cockrell K, et al. Hypertension, cardiac hypertrophy, and neurohumoral activity in a new animal model of obesity. Am J Physiol 1996;271:373\u20138.10.1152\/ajpheart.1996.271.1.H3738760195","DOI":"10.1152\/ajpheart.1996.271.1.H373"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_026_w2aab2b8c38b1b7b1ab2ac26Aa","doi-asserted-by":"crossref","unstructured":"Bray GA, Paeratakul S, Popkin BM. Dietary fat and obesity: a review of animal, clinical and epidemiological studies. Physiol Behav 2004;83:549\u201355.10.1016\/j.physbeh.2004.08.03915621059","DOI":"10.1016\/j.physbeh.2004.08.039"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_027_w2aab2b8c38b1b7b1ab2ac27Aa","doi-asserted-by":"crossref","unstructured":"Lutsey PL, Steffen LM, Stevens J. Dietary intake and the development of the metabolic syndrome; the atherosclerosis risk in communities study. Circulation 2008;117:754\u201361.10.1161\/CIRCULATIONAHA.107.71615918212291","DOI":"10.1161\/CIRCULATIONAHA.107.716159"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_028_w2aab2b8c38b1b7b1ab2ac28Aa","doi-asserted-by":"crossref","unstructured":"Hasty AH, Shimano H, Osuga J, Namatame I, Takahashi A, Yahagi N, et al. Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 2001;276:37402\u20138.10.1074\/jbc.M010176200","DOI":"10.1074\/jbc.M010176200"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_029_w2aab2b8c38b1b7b1ab2ac29Aa","doi-asserted-by":"crossref","unstructured":"Despres JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, et al. Abdominal obesity and the metabolic syndrome: contribution to global cardio metabolic risk. Arterioscler Thromb Vasc Biol 2008;28:1039\u201349.10.1161\/ATVBAHA.107.159228","DOI":"10.1161\/ATVBAHA.107.159228"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_030_w2aab2b8c38b1b7b1ab2ac30Aa","doi-asserted-by":"crossref","unstructured":"Satoh N, Wada H, Ono K, Yamakage H, Yamada K, Nakano T, et al. Small dense LDL-cholesterol relative to LDL-cholesterol is a strong independent determinant of hypoadiponectinemia in metabolic syndrome. Circ J 2008;72:932\u20139.10.1253\/circj.72.932","DOI":"10.1253\/circj.72.932"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_031_w2aab2b8c38b1b7b1ab2ac31Aa","doi-asserted-by":"crossref","unstructured":"Fitch ME, Mangels AR, Altmann WA, El Hawry M, Qureshi AA, Elson CE. Microbiological screening of mevalonatesupressive minor plant constituents. J Agric Food Chem 1989;37:687\u201391.10.1021\/jf00087a024","DOI":"10.1021\/jf00087a024"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_032_w2aab2b8c38b1b7b1ab2ac32Aa","doi-asserted-by":"crossref","unstructured":"Voors AA, Oosterga M, Buikema H, May JF, Grandjean JG, van Buiten A, et al. Dyslipidemia and endothelium-dependent relaxation in internal mammary arteries used for coronary bypass surgery. Cardiovasc Res 1977;34:568\u201374.10.1016\/S0008-6363(97)00081-3","DOI":"10.1016\/S0008-6363(97)00081-3"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_033_w2aab2b8c38b1b7b1ab2ac33Aa","doi-asserted-by":"crossref","unstructured":"Park JB, Touyz RM, Chen X, Schiffrin EL. Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt- loaded strokeprone spontaneously hypertensive rats. Am J Hypertens 2002;15:78\u201384.10.1016\/S0895-7061(01)02233-6","DOI":"10.1016\/S0895-7061(01)02233-6"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_034_w2aab2b8c38b1b7b1ab2ac34Aa","doi-asserted-by":"crossref","unstructured":"Vaziri ND, Dicus M, Ho ND, Boroujerdi-Rad L, Sindhu RK. Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency. Kidney Int 2003;63:179\u201385.10.1046\/j.1523-1755.2003.00702.x12472781","DOI":"10.1046\/j.1523-1755.2003.00702.x"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_035_w2aab2b8c38b1b7b1ab2ac35Aa","doi-asserted-by":"crossref","unstructured":"Delles C, Miller WH, Dominiczak AF. Targeting reactive oxygen species in hypertension. Antioxid Redox Sign 2008;10:1061\u201377.10.1089\/ars.2007.200818321202","DOI":"10.1089\/ars.2007.2008"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_036_w2aab2b8c38b1b7b1ab2ac36Aa","doi-asserted-by":"crossref","unstructured":"Tsukahara H, Hiraoka M, Kobata R, Hata I, Ohshima Y, Jiang MZ, et al. Increased oxidative stress in rats with chronic nitric oxide depletion: measurement of urinary 8-hydroxy-2-deoxyguanosine excretion. Redox Rep 2000;5:23\u20138.10.1179\/rer.2000.5.1.2310905540","DOI":"10.1179\/rer.2000.5.1.23"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_037_w2aab2b8c38b1b7b1ab2ac37Aa","unstructured":"Rouanet JM, Decorde K, Del Rio D, Auger C, Borges G, Cristol JP, et al. Berry juices, teas, antioxidants and the prevention of atherosclerosis in hamsters. Food Chem 2010;1182:66\u201371.10.1016\/j.foodchem.2009.04.116"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_038_w2aab2b8c38b1b7b1ab2ac38Aa","doi-asserted-by":"crossref","unstructured":"Vijayakumar RS, Nalini N. Efficacy of piperine, an alkaloidal constituent from Piper nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats. Cell Biochem Funct 2006;24:491\u20138.10.1002\/cbf.1331","DOI":"10.1002\/cbf.1331"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_039_w2aab2b8c38b1b7b1ab2ac39Aa","doi-asserted-by":"crossref","unstructured":"Choi HS, Song HS, Ukeda H, Sawamura M. Radical-scavenging activities of citrus essential oils and their components: detection using 1,1-diphenyl-2- picrylhydrazyl. J Agric Food Chem 2000;48:41\u201356.10.1021\/jf000227d","DOI":"10.1021\/jf000227d"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_040_w2aab2b8c38b1b7b1ab2ac40Aa","doi-asserted-by":"crossref","unstructured":"Woollett LA, Spady DK, Dietschy JM. Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor and production rate. J Lipid Res 1922;33:77\u201388.10.1016\/S0022-2275(20)41885-1","DOI":"10.1016\/S0022-2275(20)41885-1"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_041_w2aab2b8c38b1b7b1ab2ac41Aa","doi-asserted-by":"crossref","unstructured":"Slim RM, Toborek M, Watkins BA, Boissonneault GA, Hennig B. Susceptibility to hepatic oxidative stress in rabbits fed different animal and plant fats. J Am Coll Nutr 2006;15:289\u201394.10.1080\/07315724.1996.10718600","DOI":"10.1080\/07315724.1996.10718600"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_042_w2aab2b8c38b1b7b1ab2ac42Aa","unstructured":"Farooqui A, Ong WY, Horrocks LA. Neurochemical aspects of excitotoxicity. New York: Springer, 2008."},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_043_w2aab2b8c38b1b7b1ab2ac43Aa","doi-asserted-by":"crossref","unstructured":"Kedziora-kornatowska K, Szram S, Kornatowski T, Szadujkis-Szadurski L, Kedziora K, Bartosz G. Effect of vitamin E and vitamin C supplementation of antioxidative state and renal glomerular basement membrane thickness in diabetic kidney. Exp Nephrol 2003;95:134\u201343.10.1159\/000074840","DOI":"10.1159\/000074840"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_044_w2aab2b8c38b1b7b1ab2ac44Aa","doi-asserted-by":"crossref","unstructured":"Kirkman HN, Gaetani GF. Mammalian catalase: a venerable enzyme with new mysteries. Trends Biochem Sci 2007;3:44\u201350.10.1016\/j.tibs.2006.11.003","DOI":"10.1016\/j.tibs.2006.11.003"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_045_w2aab2b8c38b1b7b1ab2ac45Aa","doi-asserted-by":"crossref","unstructured":"Brigelius-Flohe R. Tissue-specific functions of individual glutathione peroxidases. Free Radic Biol Med 1995;27:951\u201365.10.1016\/S0891-5849(99)00173-2","DOI":"10.1016\/S0891-5849(99)00173-2"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_046_w2aab2b8c38b1b7b1ab2ac46Aa","unstructured":"Seema Farhath MS, Vijaya PP, Vimal M. Antioxidant activity of geraniol, geranial acetate, gingerol and eugenol. Res Pharm 2013;3:1\u20136."},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_047_w2aab2b8c38b1b7b1ab2ac47Aa","doi-asserted-by":"crossref","unstructured":"Vijayakumar RS, Surya D, Nalini N. Antioxidant efficiency of black pepper and piperine in rats with high fat diet induced oxidative stress. Redox Rep 2004;9:105\u201310.10.1179\/13510000422500474215231065","DOI":"10.1179\/135100004225004742"},{"key":"2025121209142400967_j_jbcpp-2014-0057_ref_048_w2aab2b8c38b1b7b1ab2ac48Aa","doi-asserted-by":"crossref","unstructured":"Zhang H, Liu H, Davies KJ, Sioutas C, Finch CE, Morgan TE, et al. Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med 2012;2:2038\u201346.10.1016\/j.freeradbiomed.2012.02.042334286322401859","DOI":"10.1016\/j.freeradbiomed.2012.02.042"}],"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2014-0057\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2014-0057\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:52:43Z","timestamp":1765540363000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2014-0057\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,6]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,5,7]]},"published-print":{"date-parts":[[2015,7,1]]}},"alternative-id":["10.1515\/jbcpp-2014-0057"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2014-0057","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"value":"2191-0286","type":"electronic"},{"value":"0792-6855","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11,6]]}}}