{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:49:41Z","timestamp":1770418181413,"version":"3.49.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    <jats:italic>Flacourtia indica<\/jats:italic>\n                    (Burm. f.) Merr. is a medicinal plant indigenous to India and is broadly used worldwide for the treatment of a variety of health ailments. The present study was experimented on hyperlipidemic Charles Foster rats with the aim to explore the possible mechanism responsible for the antidyslipidemic activity of the hydromethanolic extract from\n                    <jats:italic>F. indica<\/jats:italic>\n                    leaves (FIL).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Hyperlipidemia was induced by a single intraperitoneal dose of Triton WR-1339 in Charles Foster rats. The plasma lipid levels were estimated in control and treated groups. The antioxidant potential of\n                    <jats:italic>F. indica<\/jats:italic>\n                    was assessed in both enzymatic and non-enzymatic systems. An acute toxicity study of high-performance liquid chromatography (HPLC)-fingerprinted extract was carried out in Swiss albino mice.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The\n                    <jats:italic>F. indica<\/jats:italic>\n                    extract at a dose of 150 mg\/kg significantly lowers the plasma level of total cholesterol (17%), triglycerides (13%), and phospholipids (16%) by increasing post-heparin lipolytic activity (19%) and lecithin-cholesterol-acyltransferase activity (20%) in Triton-induced hyperlipidemic rats. In addition, the\n                    <jats:italic>F. indica<\/jats:italic>\n                    extract showed significant in vitro antioxidant and anti-adipogenic activity. HPLC analysis indicates the presence of flavanones and flavones in the extract, and the extract was found to be non-toxic up to a dose of 2000 mg\/kg body weight in the acute oral toxicity study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These finding suggest that\n                    <jats:italic>F. indica<\/jats:italic>\n                    holds significant potential in preventing clinical deterioration induced by dyslipidemia along with oxidative stress.\n                  <\/jats:p>","DOI":"10.1515\/jbcpp-2015-0017","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T07:11:00Z","timestamp":1457507460000},"page":"121-129","source":"Crossref","is-referenced-by-count":19,"title":["A mechanism-based pharmacological evaluation of efficacy of\n                    <i>Flacourtia indica<\/i>\n                    in management of dyslipidemia and oxidative stress in hyperlipidemic rats"],"prefix":"10.1515","volume":"27","author":[{"given":"Shiv Vardan","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Jyotshna","sequence":"additional","affiliation":[{"name":"Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research (CSIR), Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Upma","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhash Chandra","family":"Singh","sequence":"additional","affiliation":[{"name":"Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research (CSIR), Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karuna","family":"Shanker","sequence":"additional","affiliation":[{"name":"Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research (CSIR), Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitendra K.","family":"Saxena","sequence":"additional","affiliation":[{"name":"Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitika","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirban","family":"Pal","sequence":"additional","affiliation":[{"name":"Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research (CSIR), Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,10,21]]},"reference":[{"key":"2025121209201100973_j_jbcpp-2015-0017_ref_001_w2aab2b8c18b1b7b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Celermajer DS, Chow CK, Marijon E, Anstey NM, Woo KS. 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