{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:10:42Z","timestamp":1765541442393,"version":"3.48.0"},"reference-count":43,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2015-0144_s_999_w2aab2b8c29b1b7b1aab1c14b1Aa\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aims to investigate whether tested organic extracts possess antithrombotic properties with minimal or no toxicity and to predict the activity of some of their isolated compounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2015-0144_s_998_w2aab2b8c29b1b7b1aab1c14b2Aa\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      An in vitro thrombolytic model was used to check the clot lysis effect of four Bangladeshi herbal extracts viz., roots of\n                      <jats:italic>Curculigo recurvata<\/jats:italic>\n                      W.T. Aiton (Satipata), leaf of\n                      <jats:italic>Amorphophallus bulbifer<\/jats:italic>\n                      Roxb. (Olkachu), leaf of\n                      <jats:italic>Phyllanthus sikkimensis<\/jats:italic>\n                      Muell. Arg., and whole plant of\n                      <jats:italic>Thunbergia grandiflora<\/jats:italic>\n                      Roxb. (Nillata) using streptokinase as a positive control and water as a negative control. Cytotoxicity was screened by brine shrimp lethality bioassay using vincristine sulfate as positive control. In silico prediction of activity spectra for substances (PASS) prediction was applied for phytoconstituents, namely, nyasicoside, glucomannan, grandifloric acid, serine, and alanine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2015-0144_s_997_w2aab2b8c29b1b7b1aab1c14b3Aa\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Using an in vitro thrombolytic model,\n                      <jats:italic>C. recurvata<\/jats:italic>\n                      ,\n                      <jats:italic>A. bulbifer<\/jats:italic>\n                      ,\n                      <jats:italic>P. sikkimensis<\/jats:italic>\n                      , and\n                      <jats:italic>T. grandiflora<\/jats:italic>\n                      showed 28.10\u00b11.64%, 42.47\u00b11.96%, 32.86\u00b11.92%, and 25.51\u00b11.67% of clot lysis, respectively. Reference drug streptokinase exhibited 75.00\u00b13.04% clot lysis. Examined herbs showed significant (p&lt;0.001) percentage (%) of clot lysis compared to negative control. In brine shrimp cytotoxic assay,\n                      <jats:italic>C. recurvata<\/jats:italic>\n                      ,\n                      <jats:italic>A. bulbifer<\/jats:italic>\n                      ,\n                      <jats:italic>P. sikkimensis<\/jats:italic>\n                      , and\n                      <jats:italic>T. grandiflora<\/jats:italic>\n                      showed LC\n                      <jats:sub>50<\/jats:sub>\n                      values 210.64\u00b13.44, 98.51\u00b11.47, 187.29\u00b12.01, and 386.43\u00b13.02 \u03bcg\/mL, respectively, with reference to vincristine sulfate (LC\n                      <jats:sub>50<\/jats:sub>\n                      0.76\u00b10.04). PASS predicted that examined phytoconstituents have a wide range of biological activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2015-0144_s_996_w2aab2b8c29b1b7b1aab1c14b4Aa\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Through our study it was found that\n                      <jats:italic>A. bulbifer<\/jats:italic>\n                      and\n                      <jats:italic>P. sikkimensis<\/jats:italic>\n                      could be considered as very promising and beneficial thrombolytic agents.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2015-0144","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T06:00:34Z","timestamp":1477548034000},"page":"659-666","source":"Crossref","is-referenced-by-count":7,"title":["Antithrombotic and cytotoxic activities of four Bangladeshi plants and PASS prediction of their isolated compounds"],"prefix":"10.1515","volume":"27","author":[{"given":"Mohammad Shah Hafez","family":"Kabir","sequence":"first","affiliation":[{"name":"Department of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. 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