{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:05:26Z","timestamp":1773234326005,"version":"3.50.1"},"reference-count":8,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2016-0037_s_999_w2aab2b8c43b1b7b1aab1c15b1Aa\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Blepharospasm is one of the components of drug-induced Meige\u2019s syndrome which is reported to be caused by typical antipsychotics. Reports of blepharospasm or Meige\u2019s syndrome caused by atypical antipsychotics are rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0037_s_998_w2aab2b8c43b1b7b1aab1c15b2Aa\">\n                    <jats:title>Case:<\/jats:title>\n                    <jats:p>A 30-year-old female patient presented to psychiatry out patient department (OPD) with chief complaints of inability to keep her eyes open for long and excessive blinking for 2 months, irritation of eyes, watery discharge from eyes and photophobia for last 1 month. The patient had been taking olanzapine 10 mg, sertraline 100 mg and divalproex sodium 500 mg per orally on once a day basis for the management of major depressive disorder with psychotic features for last 6 months. Routine blood analysis, thyroid function, EEG, MRI, lipid profile did not reveal any abnormality. Ocular examination was also within normal limits. Olanzapine was suspected as a culprit for the above symptoms of patient, so it was replaced with quetiapine 25 mg\/day. Patient showed partial recovery of symptoms within 1 week and complete recovery within 2 months of stopping olanzapine. Causality of olanzapine-induced blepharospasm as per WHO-UMC scale was probable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0037_s_997_w2aab2b8c43b1b7b1aab1c15b3Aa\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Olanzapine (atypical antipsychotics) should also be kept in the list of suspected drugs causing blepharospasm in psychotic patients on treatment although further similar evidences from observational studies and\/or reports are needed to establish the causal relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2016-0037","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T08:58:06Z","timestamp":1474534686000},"page":"85-87","source":"Crossref","is-referenced-by-count":8,"title":["Blepharospasm: an uncommon adverse effect caused by long-term administration of olanzapine"],"prefix":"10.1515","volume":"28","author":[{"given":"Tarun","family":"Arora","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Lady Hardinge Medical College & SSK Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Maharshi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harmeet S.","family":"Rehan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Lady Hardinge Medical College & SSK Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravesh","family":"Nagar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Lady Hardinge Medical College & SSK Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"2025121209175098171_j_jbcpp-2016-0037_ref_001_w2aab2b8c43b1b7b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Debadatta M, Mishra AK. Meige\u2019s syndrome: rare neurological disorder presenting as conversion disorder. Indian J Psychol Med 2013;35:317\u201318.","DOI":"10.4103\/0253-7176.119493"},{"key":"2025121209175098171_j_jbcpp-2016-0037_ref_002_w2aab2b8c43b1b7b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Aggarwal A, Jain M, Khandelwal A, Jiloha RC. Tardive Meige\u2019s syndrome associated with olanzapine. Ann Indian Acad Neurol 2011;14:133\u20134.","DOI":"10.4103\/0972-2327.82808"},{"key":"2025121209175098171_j_jbcpp-2016-0037_ref_003_w2aab2b8c43b1b7b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Prashanth IK, Kumar RS, Raghavendra S, Kuruvilla A. Meige\u2019s syndrome. In: Kumar A, editor. Text book of movement disorders, 1st ed. New Delhi: Jaypee Brothers Medical Publishers, 2014:257\u201361.","DOI":"10.5005\/jp\/books\/12347_31"},{"key":"2025121209175098171_j_jbcpp-2016-0037_ref_004_w2aab2b8c43b1b7b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Ananth J, Burgoyne K, Aquino S. Meige\u2019s syndrome associated with risperidone therapy. Am J Psychiatry 2000;157:149.","DOI":"10.1176\/ajp.157.1.149"},{"key":"2025121209175098171_j_jbcpp-2016-0037_ref_005_w2aab2b8c43b1b7b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Nishikawa T, Nishioka S. A case of Meige dystonia induced by short-term quetiapine treatment. Hum Psychopharmacol 2002;17:197.","DOI":"10.1002\/hup.391"},{"key":"2025121209175098171_j_jbcpp-2016-0037_ref_006_w2aab2b8c43b1b7b1ab2b2b6Aa","doi-asserted-by":"crossref","unstructured":"Tolosa ES, Lai C. Meige disease: striatal dopaminergic preponderance. Neurology 1979;29:1126\u201330.","DOI":"10.1212\/WNL.29.8.1126"},{"key":"2025121209175098171_j_jbcpp-2016-0037_ref_007_w2aab2b8c43b1b7b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Jankovic J. Treatment of hyperkinetic movement disorders with tetrabenazine: a double-blind crossover study. Ann Neurol 1982;11:41\u20137.","DOI":"10.1002\/ana.410110108"},{"key":"2025121209175098171_j_jbcpp-2016-0037_ref_008_w2aab2b8c43b1b7b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Kapur S, Zipursky RB, Remington G, Jones C, DaSilva J, Wilson AA, et al. 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. Am J Psychiatry 1998;155:921\u20138.","DOI":"10.1176\/ajp.155.7.921"}],"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jbcpp.2017.28.issue-1\/jbcpp-2016-0037\/jbcpp-2016-0037.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2016-0037\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2016-0037\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:02:53Z","timestamp":1765540973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2016-0037\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,22]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,10,4]]},"published-print":{"date-parts":[[2017,1,1]]}},"alternative-id":["10.1515\/jbcpp-2016-0037"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2016-0037","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"value":"2191-0286","type":"electronic"},{"value":"0792-6855","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9,22]]}}}