{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:57:13Z","timestamp":1771657033651,"version":"3.50.1"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2016-0086_s_999_w2aab2b8c65b1b7b1aab1c14b1Aa\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Sanchezia speciosa<\/jats:italic>\n                      has been used in traditional medicine for gastritis treatment in Vietnam. Some phytochemical study showed that\n                      <jats:italic>S. speciosa<\/jats:italic>\n                      contains high amounts of flavonoids and cardiac glycoside compounds. In the present study, we isolated four compounds from the ethanol extract of the\n                      <jats:italic>S. speciosa<\/jats:italic>\n                      leaf, and we evaluated the in vitro antioxidant and anti-inflammatory effect of the isolated compound from the ethanol extract of the\n                      <jats:italic>S. speciosa<\/jats:italic>\n                      leaf.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0086_s_998_w2aab2b8c65b1b7b1aab1c14b2Aa\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The leaf of\n                      <jats:italic>S. speciosa<\/jats:italic>\n                      Leonard was extracted with ethanol 96%. Compounds were isolated using column chromatography and identified by spectroscopic method, including IR, MS, and NMR and by comparing their physicochemical and spectral data with those published in literatures. These isolated compounds were investigated for their antioxidant activity using DPPH and inflammation inhibitory activity by inhibition of albumin denaturation assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0086_s_997_w2aab2b8c65b1b7b1aab1c14b3Aa\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We have isolated four compounds quercetin 3-\n                      <jats:italic>O<\/jats:italic>\n                      -\n                      <jats:italic>\u03b1<\/jats:italic>\n                      -\n                      <jats:sc>l<\/jats:sc>\n                      -rhamnopyranosid (\n                      <jats:italic>quercitrin<\/jats:italic>\n                      ) (1), quercetin 3-\n                      <jats:italic>O-\u03b2-<\/jats:italic>\n                      <jats:sc>d<\/jats:sc>\n                      -galactopyranosid\n                      <jats:italic>(hyperosid)<\/jats:italic>\n                      (2), sitosterol-3-O-\u03b2-D-glucopyranosid\n                      <jats:italic>(daucosterol)<\/jats:italic>\n                      (3), and 3-methyl-1H-benz[f]indole-4,9-dione (4) from the ethanolic extract of the\n                      <jats:italic>S. speciosa<\/jats:italic>\n                      leaf. The antioxidant activities were in the following order: compound\n                      <jats:bold>2<\/jats:bold>\n                      &gt;compound 1&gt;compound\n                      <jats:bold>4<\/jats:bold>\n                      &gt;compound\n                      <jats:bold>3<\/jats:bold>\n                      . The IC\n                      <jats:sub>50<\/jats:sub>\n                      values of scavenging DPPH radicals for compound\n                      <jats:bold>2<\/jats:bold>\n                      was 20.83\u00b11.29 \u03bcg\/mL. For anti-inflammatory activities, the order was compound\n                      <jats:bold>4<\/jats:bold>\n                      &gt;compound\n                      <jats:bold>3<\/jats:bold>\n                      &gt;compound\n                      <jats:bold>2<\/jats:bold>\n                      &gt;compound\n                      <jats:bold>1<\/jats:bold>\n                      . Compound\n                      <jats:bold>4<\/jats:bold>\n                      showed the strongest inhibition, with IC50 values of 193.70\u00b15.24 \u00b5g\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0086_s_996_w2aab2b8c65b1b7b1aab1c14b4Aa\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      These compounds\n                      <jats:bold>1<\/jats:bold>\n                      ,\n                      <jats:bold>2<\/jats:bold>\n                      , and\n                      <jats:bold>4<\/jats:bold>\n                      were isolated for the first time from the leaves of\n                      <jats:italic>S. speciosa.<\/jats:italic>\n                      These compounds showed strong antioxidant and anti-inflammatory activity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2016-0086","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T05:01:42Z","timestamp":1479445302000},"page":"79-84","source":"Crossref","is-referenced-by-count":10,"title":["In vitro antioxidant and anti-inflammatory activities of isolated compounds of ethanol extract from\n                    <i>Sanchezia speciosa<\/i>\n                    Leonard\u2019s leaves"],"prefix":"10.1515","volume":"28","author":[{"given":"Tung","family":"Bui Thanh","sequence":"first","affiliation":[{"name":"School of Medicine and Pharmacy, Vietnam National University, Hanoi, Office 506, Building Y1, 144 Xuan Thuy, Cau Giay, Ha Noi, Viet Nam , Phone: +84-4-85876172, Fax: +84-0437450188"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loi","family":"Vu Duc","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Nguyen Thanh","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacy, Vietnam National University, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vung","family":"Nguyen Tien","sequence":"additional","affiliation":[{"name":"National Institute of Forensic Medicine, Hanoi, Viet Nam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"2025121209175097520_j_jbcpp-2016-0086_ref_001_w2aab2b8c65b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Fang Y-Z, Yang S, Wu G. 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