{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:15:00Z","timestamp":1791396900935,"version":"4.3.3"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2016-0096_s_999_w2aab3b7b1b1b6b1aab1c18b1Aa\">\n                    <jats:title id=\"d21360e550_w2aab3b7b1b1b6b1aab1c18b1aAa\">Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Ocimum gratissimum<\/jats:italic>\n                      leaf is used in managing rheumatism and other inflammatory conditions. In this study, we investigated the antioxidant and anti-inflammatory effects of phenolic extract obtained by sequential methanol extraction of\n                      <jats:italic>O. gratissimum<\/jats:italic>\n                      leaves (MEO\n                      <jats:italic>g<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0096_s_998_w2aab3b7b1b1b6b1aab1c18b2Aa\">\n                    <jats:title id=\"d21360e566_w2aab3b7b1b1b6b1aab1c18b2aAa\">Methods:<\/jats:title>\n                    <jats:p>\n                      The methanol extract (MEO\n                      <jats:italic>g<\/jats:italic>\n                      ) was obtained after sequential maceration (n-hexane, chloroform and methanol) of dried\n                      <jats:italic>O. gratissimum<\/jats:italic>\n                      leaves. The fingerprint of the extract was obtained using a high-performance liquid chromatrographic method. In vitro effects were tested by 1,1-Diphenyl-2-picryl-hydrazyl (DPPH), nitric oxide (NO) free radical scavenging, lipoxygenase, and xanthine oxidase inhibitory assays. MEO\n                      <jats:italic>g<\/jats:italic>\n                      was studied for anti-inflammatory activity in carrageenan-induced paw edema and air pouch inflammation in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0096_s_997_w2aab3b7b1b1b6b1aab1c18b3Aa\">\n                    <jats:title id=\"d21360e583_w2aab3b7b1b1b6b1aab1c18b3aAa\">Results:<\/jats:title>\n                    <jats:p>\n                      HPLC fingerprint of the extract shows the presence of caffeic acid, rutin, ferulic acid, apigenin, and quercetin. Antioxidant activity of MEO\n                      <jats:italic>g<\/jats:italic>\n                      revealed an IC\n                      <jats:sub>50<\/jats:sub>\n                      value in DPPH (31.5\u00b10.03 \u03bcg\/mL) and NO assay (201.6\u00b10.01 \u03bcg\/mL), respectively. The extract demonstrated strong xanthine oxidase inhibitory and weak antilipoxygenase activities. MEO\n                      <jats:italic>g<\/jats:italic>\n                      (100 mg\/kg) significantly inhibited carrageenan-induced paw edema by 43.2%. Furthermore, MEO\n                      <jats:italic>g<\/jats:italic>\n                      (50 and 100 mg\/kg) significantly reduced exudate volume, leucocyte count, neutrophil infiltration, TNF-\u03b1, nitrites, myeloperoxidase, and malondialdehyde in carrageenan-induced air pouch inflammation. MEO\n                      <jats:italic>g<\/jats:italic>\n                      also elevated the glutathione levels in the inflammatory exudates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0096_s_996_w2aab3b7b1b1b6b1aab1c18b4Aa\">\n                    <jats:title id=\"d21360e606_w2aab3b7b1b1b6b1aab1c18b4aAa\">Conclusions:<\/jats:title>\n                    <jats:p>\n                      MEO\n                      <jats:italic>g<\/jats:italic>\n                      shows potential therapeutic benefits in slowing down inflammation and oxidative stress in chronic diseases, such as arthritis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2016-0096","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T06:04:26Z","timestamp":1490162666000},"page":"531-541","source":"Crossref","is-referenced-by-count":31,"title":["<i>Ocimum gratissimum<\/i>\n                    Linn. Leaf extract inhibits free radical generation and suppressed inflammation in carrageenan-induced inflammation models in rats"],"prefix":"10.1515","volume":"28","author":[{"given":"Abayomi M.","family":"Ajayi","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine , University of Ibadan , Ibadan , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary O.","family":"Ologe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine , University of Ibadan , Ibadan , Nigeria"},{"name":"Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences , University of Ilorin , Ilorin, Kwara State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benneth","family":"Ben-Azu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine , University of Ibadan , Ibadan , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel E.","family":"Okhale","sequence":"additional","affiliation":[{"name":"Department of Medicinal Plant Research and Traditional Medicine , National Institute for Pharmaceutical Research and Development , Abuja , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulus","family":"Adzu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology , National Institute for Pharmaceutical Research and Development , Abuja , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusegun G.","family":"Ademowo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, College of Medicine , University of Ibadan , Ibadan , Nigeria"},{"name":"Training (IAMRAT), College of Medicine , University of Ibadan , Ibadan , Nigeria , Phone: +2348023342856"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,3,22]]},"reference":[{"key":"2025121209212040396_j_jbcpp-2016-0096_ref_001_w2aab3b7b1b1b6b1ab1b7b1Aa","doi-asserted-by":"crossref","unstructured":"Garcia-Lafuente A, Guillamon E, Villares A. 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