{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:50:08Z","timestamp":1765540208225,"version":"3.48.0"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2016-0150_s_999_w2aab2b8c45b1b7b1aab1c16b1Aa\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Oxidative stress and inflammation are involved in the pathogenesis of paracetamol-induced renal damage. This study examines the relationship between 8-iso-prostaglandin F\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      (8-iso-PGF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      ) and platelet activation as well as the relative contribution of the pro-inflammatory markers interleukin (IL)-1\u03b2 and tumor necrosis factor-\u03b1 (TNF-\u03b1) in enhanced 8-iso-PGF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      biosynthesis, as a complementary onset during analgesic nephropathy induced by chronic treatment with paracetamol. The protective effects of vitamin C on the aforementioned settings are also investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0150_s_998_w2aab2b8c45b1b7b1aab1c16b2Aa\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Analgesic nephropathy was induced in Wistar rats. Renal function markers and the activity of antioxidant enzymes were determined spectrophotometrically. Immunoassays were used to measure the pro-inflammatory markers and the markers of lipid peroxidation and platelet activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0150_s_997_w2aab2b8c45b1b7b1aab1c16b3Aa\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The chronic treatment with paracetamol led to renal dysfunction, represented by the elevation of plasma urea and creatinine and the decline in the enzymatic antioxidant status, but did not cause a significant increase in TNF-\u03b1 and IL-1\u03b2. The paracetamol-induced lipid peroxidation and enhanced production of 8-iso-PGF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      was not sufficient to cause changes in platelet activation represented by the level of 11-dehydro thromboxane B\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0150_s_996_w2aab2b8c45b1b7b1aab1c16b4Aa\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Our results suggest that oxidative stress cannot circumvent the need of stimulation by circulatory cytokines in order to induce inflammatory response and changes in platelet activation during analgesic nephropathy. Vitamin C proved to be beneficial in restoring the renal function markers to normal, increasing the renal enzymatic antioxidant potential, inhibiting lipid peroxidation, and lowering cytokine production and 11-dehydro thromboxane B\n                      <jats:sub>2<\/jats:sub>\n                      excretion. The observed effects of vitamin C offer support for its potential use as protective treatment in cases of chronic paracetamol overdose.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2016-0150","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T06:01:40Z","timestamp":1501740100000},"page":"473-481","source":"Crossref","is-referenced-by-count":2,"title":["The impact of vitamin C on the relationship among inflammation, lipid peroxidation and platelet activation during analgesic nephropathy in rats"],"prefix":"10.1515","volume":"28","author":[{"given":"Nikola","family":"Hadzi-Petrushev","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Natural Sciences and Mathematics , Institute of Biology, \u201cSs. Cyril and Methodius\u201d University , Skopje , Republic of Macedonia , Phone: +389 2 3249 605, Fax: +389 2 3228 141"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dine","family":"Mitrov","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Sciences , \u201cSs. Cyril and Methodius\u201d University , Skopje , Republic of Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Kostovski","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences and Mathematics, Institute of Biology , \u201cSs. Cyril and Methodius\u201d University , Skopje , Republic of Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitko","family":"Mladenov","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences and Mathematics, Institute of Biology , \u201cSs. Cyril and Methodius\u201d University , Skopje , Republic of Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"2025121209112863647_j_jbcpp-2016-0150_ref_001_w2aab2b8c45b1b7b1ab2b1b1Aa","unstructured":"Insel PA. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In: Goodman and Gilman\u2019s, the pharmacological basis of therapeutics, 9th ed. New York: Macmillan, 1996;617\u201357."},{"key":"2025121209112863647_j_jbcpp-2016-0150_ref_002_w2aab2b8c45b1b7b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Green K, Drvota V, Vesterqvist O. Pronounced reduction of in vivo prostacyclin synthesis in humans by acetaminophen (paracetamol). 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