{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:06:25Z","timestamp":1789891585855,"version":"4.0.1"},"reference-count":41,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2016-0181_s_999_w2aab2b8c59b1b7b1aab1c16b1Aa\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      This study was carried out to evaluate the antioxidant and hepatoprotective effects of\n                      <jats:italic>Vaccinium arctostaphylos<\/jats:italic>\n                      (V.a) methanolic extract on carbon tetrachloride (CCl\n                      <jats:sub>4<\/jats:sub>\n                      )-induced acute liver injury in Wistar rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0181_s_998_w2aab2b8c59b1b7b1aab1c16b2Aa\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Total phenolic and total flavonoid contents as well as antioxidant activity of V.a were determined. Extracts of V.a at doses of 200 and 400 mg\/kg were administered by oral gavage to rats once per day for 7 days and then were given an intraperitoneal injection of 1 mL\/kg CCl\n                      <jats:sub>4<\/jats:sub>\n                      (1:1 in olive oil) for 3 consecutive days. Serum biochemical markers of liver injury, oxidative markers, as well as hydroxyproline (HP) content and histopathology of liver were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0181_s_997_w2aab2b8c59b1b7b1aab1c16b3Aa\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The obtained results showed that V.a had strong antioxidant activity. Treatment of rats with V.a blocked the CCl\n                      <jats:sub>4<\/jats:sub>\n                      -induced elevation of serum markers of liver function and enhanced albumin and total protein levels. The level of hepatic HP content was also reduced by the administration of V.a treatment. Histological examination of the liver section revealed that V.a prevented the occurrence of pathological changes in CCl\n                      <jats:sub>4<\/jats:sub>\n                      -treated rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2016-0181_s_996_w2aab2b8c59b1b7b1aab1c16b4Aa\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      These findings suggested that V.a may be useful in the treatment and prevention of hepatic injury induced by CCl\n                      <jats:sub>4<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2016-0181","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T06:01:29Z","timestamp":1493791289000},"page":"463-471","source":"Crossref","is-referenced-by-count":23,"title":["Hepatoprotective effects of\n                    <i>Vaccinium arctostaphylos<\/i>\n                    against CCl\n                    <sub>4<\/sub>\n                    -induced acute liver injury in rats"],"prefix":"10.1515","volume":"28","author":[{"given":"Alireza Pouyandeh","family":"Ravan","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences , School of Para Medicine , Hamadan University of Medical Sciences , Hamadan , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Bahmani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Medical School , Hamadan University of Medical Sciences , Hamadan , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Reza","family":"Ghasemi Basir","sequence":"additional","affiliation":[{"name":"Department of Pathology , Hamadan University of Medical Sciences , Hamadan , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraj","family":"Salehi","sequence":"additional","affiliation":[{"name":"Neurophysiology Research Center , Hamadan University of Medical Sciences , Hamadan , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim Abbasi","family":"Oshaghi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Medical School , Hamadan University of Medical Sciences , Hamadan , Iran"},{"name":"Neurophysiology Research Center , Hamadan University of Medical Sciences , Hamadan , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"2025121209112865901_j_jbcpp-2016-0181_ref_001_w2aab2b8c59b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Mistry S, Dutt K, Jena J. 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