{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:42Z","timestamp":1790885562672,"version":"4.1.0"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2017-0011_s_999_w2aab3b7b7b1b6b1aab1c17b1Aa\">\n                    <jats:title id=\"d1987534e23732_w2aab3b7b7b1b6b1aab1c17b1aAa\">Background:<\/jats:title>\n                    <jats:p>\n                      Elevation of phosphodiesterase-5 (PDE5) activity converts cyclic guanosine monophosphate (cGMP) to 5\u2032-GMP, a mechanism that could be associated with drug-mediated hepatotoxicity. This study investigated whether selective inhibition of PDE5 by sildenafil could offer protection against hepatotoxicity induced by carbon tetrachloride (CCl\n                      <jats:sub>4<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0011_s_998_w2aab3b7b7b1b6b1aab1c17b2Aa\">\n                    <jats:title id=\"d1987534e23743_w2aab3b7b7b1b6b1aab1c17b2aAa\">Methods:<\/jats:title>\n                    <jats:p>\n                      CCl\n                      <jats:sub>4<\/jats:sub>\n                      (0.5 mL\/kg) was administered intraperitoneally to induce hepatotoxicity. The control group received normal saline. Sildenafil (5 mg, 10 mg, and 20 mg\/kg, p.o.) was administered to CCl\n                      <jats:sub>4<\/jats:sub>\n                      -treated rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0011_s_997_w2aab3b7b7b1b6b1aab1c17b3Aa\">\n                    <jats:title id=\"d1987534e23757_w2aab3b7b7b1b6b1aab1c17b3aAa\">Results:<\/jats:title>\n                    <jats:p>\n                      CCl\n                      <jats:sub>4<\/jats:sub>\n                      significantly increased the serum levels of gamma glutamyl transferase (\u03b3-GT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) and reduced total protein (TP) (p&lt;0.05). Pretreatment with sildenafil moderately reduced ALP, AST, and ALT activities with modest increase in TP level. CCl\n                      <jats:sub>4<\/jats:sub>\n                      -induced changes in the antioxidant status of the liver were significantly improved by sildenafil, especially at the lowest dose of 5 mg\/kg by elevating the levels of reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and glutathione-S-transferase (GST) and preventing lipid peroxidation (p&lt;0.05). Sildenafil did not significantly alter the total cholesterol and triglyceride levels. However, high-density lipoprotein (HDL) level was significantly increased by sildenafil (p&lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0011_s_996_w2aab3b7b7b1b6b1aab1c17b4Aa\">\n                    <jats:title id=\"d1987534e23771_w2aab3b7b7b1b6b1aab1c17b4aAa\">Conclusions:<\/jats:title>\n                    <jats:p>\n                      The results from this study suggest that sildenafil, when used at low doses, may be a useful pharmacological protective agent against CCl\n                      <jats:sub>4<\/jats:sub>\n                      -induced hepatotoxicity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2017-0011","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T17:16:19Z","timestamp":1514481379000},"page":"29-35","source":"Crossref","is-referenced-by-count":14,"title":["Sildenafil, a phosphodiesterase-5 inhibitor, offers protection against carbon tetrachloride-induced hepatotoxicity in rat"],"prefix":"10.1515","volume":"29","author":[{"given":"Olorunfemi R.","family":"Molehin","sequence":"first","affiliation":[{"name":"Department of Biochemistry , Faculty of Science , Ekiti State University , Ado-Ekiti. 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