{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:29:10Z","timestamp":1787506150789,"version":"build-2736575974"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2017-0030_s_999_w2aab3b7b2b1b6b1aab1c17b1Aa\">\n                    <jats:title id=\"d39162e3797_w2aab3b7b2b1b6b1aab1c17b1aAa\">Background<\/jats:title>\n                    <jats:p>The prevalence of obesity is reported to be increasing owing to the high intake of dietary fat and is a predisposing risk factor with associated complex metabolic syndromes in the human population. Preclinical rodent models play a pivotal role in understanding the pathogenesis of obesity and development of new treatment strategies for humans. High-fat-diet (HFD)-induced rodents are used for chronic obesity models owing to their quick adaptation to high-fat diets and rapid body weight gain and different rats (Wistar Sprague-Dawley and Lewis) have been used by various researchers. However, the selection of appropriate stock contributes to the translation of clinically linked disease phenotypes to preclinical animal models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0030_s_998_w2aab3b7b2b1b6b1aab1c17b2Aa\">\n                    <jats:title id=\"d39162e3805_w2aab3b7b2b1b6b1aab1c17b2aAa\">Methods<\/jats:title>\n                    <jats:p>The study was conducted using two commonly used rat stocks Hsd:Sprague-Dawley (SD) and Crl:Charles River (CD) to develop a chronic high-fat-diet-induced obesity model (DIO) to explore the underlying mechanisms of obesity and its utilization in drug discovery and development during preclinical stages. In addition two high-fat diets of different composition were evaluated (D12327; 40% kcal fat and D12492; 60% kcal fat) for their potential to induce obesity using these two stocks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0030_s_997_w2aab3b7b2b1b6b1aab1c17b3Aa\">\n                    <jats:title id=\"d39162e3813_w2aab3b7b2b1b6b1aab1c17b3aAa\">Results<\/jats:title>\n                    <jats:p>A differential sensitivity to HFD was observed in body weight gain fat mass composition and obesity-linked symptoms such as impaired glucose tolerance insulin and leptin levels. The comparative research findings of Hsd:SD and Crl:CD rat stocks suggested that Crl:CD rats are more prone to diet-induced obesity and its associated complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0030_s_996_w2aab3b7b2b1b6b1aab1c17b4Aa\">\n                    <jats:title id=\"d39162e3821_w2aab3b7b2b1b6b1aab1c17b4aAa\">Conclusions<\/jats:title>\n                    <jats:p>Crl:CD rats were found to be a suitable model for obesity over Hsd:SD when considering the important hallmarks of metabolic disorders that may be utilized for obesity-related research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2017-0030","type":"journal-article","created":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T18:16:37Z","timestamp":1533406597000},"page":"553-563","source":"Crossref","is-referenced-by-count":4,"title":["Differential sensitivity of chronic high-fat-diet-induced obesity in Sprague-Dawley rats"],"prefix":"10.1515","volume":"29","author":[{"given":"Shakthi R.K.","family":"Devan","sequence":"first","affiliation":[{"name":"Syngene International Limited, Biocon Bristol-Myers Squibb R&D Center , Biocon Park, Bommasandra IV phase , Bangalore 560 099 , India , Phone: +91 80 6633 4245"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendar","family":"Arumugam","sequence":"additional","affiliation":[{"name":"Syngene International Limited, Biocon Bristol-Myers Squibb R&D Center , Biocon Park, Bommasandra IV phase , Bangalore 560 099 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Shankar","sequence":"additional","affiliation":[{"name":"Syngene International Limited, Biocon Bristol-Myers Squibb R&D Center , Biocon Park, Bommasandra IV phase , Bangalore 560 099 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Poosala","sequence":"additional","affiliation":[{"name":"Bristol-Myers Squibb India Pvt. 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