{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:37:40Z","timestamp":1773484660023,"version":"3.50.1"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2017-0037_s_999_w2aab2b8c26b1b7b1aab1c15b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dipyrone is a non-narcotic analgesic\/antipyretic widely used in some countries but prohibited in others due to suspected risk of agranulocytosis. The primary goal of this study was to evaluate hematological alterations in healthy adult volunteers after treatment with dipyrone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0037_s_998_w2aab2b8c26b1b7b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study enrolled 30 healthy volunteers of both genders, aged 19\u201337 years. They received tablets containing 500 mg of dipyrone sodium to be used four times daily for 7 consecutive days. Before the first administration, arterial pressure was measured and blood was collected in order to evaluate hematological baseline parameters. On the 8th day after the beginning of treatment, the volunteers had their blood pressure assessed once more and underwent a second blood draw. Total and specific leukocyte counts, creatinine, urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), erythrocytes, and platelets were quantitatively determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0037_s_997_w2aab2b8c26b1b7b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No statistically significant difference was observed among total or specific leukocyte counts. Number of platelets, erythrocytes, hemoglobin, and hematocrit decreased after treatment. Diastolic pressure, mean arterial pressure (MAP), and urea concentration declined, while creatinine, AST, and ALT showed no significant alterations. It is noteworthy that, even for parameters that showed statistically significant changes, the highest and lowest values remained within the normal ranges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0037_s_996_w2aab2b8c26b1b7b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although dipyrone has historically been associated with agranulocytosis, leukocyte counts remained practically unchanged after oral administration of dipyrone. On the other hand, the present study adds evidence that dipyrone is able to produce statistically relevant decrease in number of platelets, erythrocytes, hemoglobin, and hematocrit in healthy adults, even after short-term treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2017-0037","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T17:15:58Z","timestamp":1518455758000},"page":"385-390","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of hematological alterations after therapeutic use of dipyrone in healthy adults: a prospective study"],"prefix":"10.1515","volume":"29","author":[{"given":"Ernane C.","family":"de Souza","sequence":"first","affiliation":[{"name":"University of Iowa College of Pharmacy, Division of Medicinal and Natural Products Chemistry , Iowa City, IA , USA"},{"name":"Department of Pharmaceutical Sciences, College of Pharmacy , Federal University of Juiz de Fora , Juiz de Fora, MG , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalyara M.","family":"Matos","sequence":"additional","affiliation":[{"name":"Post graduation Program in Pharmaceutical Sciences , Federal University of Juiz de Fora , Juiz de Fora, MG , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milainy R.","family":"Viana","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy , Federal University of Juiz de Fora , Juiz de Fora, MG , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela C.O.","family":"Alvim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy , Federal University of Juiz de Fora , Juiz de Fora, MG , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herval L.","family":"Bonfante","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biological Sciences , Federal University of Juiz de Fora , Juiz de Fora, MG , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre F.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy , Federal University of Juiz de Fora , Juiz de Fora, MG , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge W.L.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora, Instituto de Ci\u00eancias Biol\u00f3gicas , Laborat\u00f3rio de Farmacologia Cl\u00ednica e Experimental (LaFaCE) , Departamento de Farmacologia , Rua Jos\u00e9 Louren\u00e7o Kelmer, s\/n. 36036-900 , Juiz de Fora, MG , Brasil , Phone: +55 32 2102-3369; 55 32 2102-3210, Fax: +55 32 2102-3216"},{"name":"Post graduation Program in Pharmaceutical Sciences , Federal University of Juiz de Fora , 36036-900 , Juiz de Fora, MG , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"2025121209175628051_j_jbcpp-2017-0037_ref_001_w2aab2b8c26b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Hinz B, Cheremina O, Bachmakov J, Renner B, Zolk O, Fromm MF, et al. 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