{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:14:16Z","timestamp":1790194456640,"version":"4.1.0"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2017-0045_s_999_w2aab3b7b9b1b6b1aab1c17b1Aa\">\n                    <jats:title id=\"d1987534e30830_w2aab3b7b9b1b6b1aab1c17b1aAa\">Background:<\/jats:title>\n                    <jats:p>\n                      Curcumin and nisin have been widely reported for their antibacterial and anticancer potency. However, their therapeutic applications are hampered by several factors, which necessitate their development into nanosize ranges for improved delivery and activities. Their incorporation into a single nanosynthesized form may suggest desirable efficacy on parasites. The aim of the study was to assess the ovicidal activity of the curcumin-nisin polylactic acid (PLA) entrapped nanoparticle on the\n                      <jats:italic>Fasciola<\/jats:italic>\n                      eggs and its reproductive toxicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0045_s_998_w2aab3b7b9b1b6b1aab1c17b2Aa\">\n                    <jats:title id=\"d1987534e30841_w2aab3b7b9b1b6b1aab1c17b2aAa\">Methods:<\/jats:title>\n                    <jats:p>\n                      The nanoparticle was formulated by double emulsion method. The eggs of the adult\n                      <jats:italic>Fasciola<\/jats:italic>\n                      spp. were exposed to different concentrations (0.3125\u20135 mg\/mL) of the nanoparticle to monitor hatchability. Mice were exposed to 0.5 mL of the formulated drug at varying concentrations (10\u201320 mg\/kg) and then sacrificed for sperm morphology assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0045_s_997_w2aab3b7b9b1b6b1aab1c17b3Aa\">\n                    <jats:title id=\"d1987534e30852_w2aab3b7b9b1b6b1aab1c17b3aAa\">Results:<\/jats:title>\n                    <jats:p>The mean particle size, polydispersity index, and drug entrapment efficiency of the formulated drug were 288.4\u00b124.3 nm, 0.232, and 51.7%, respectively. The highest nanoparticulate concentration (5 mg\/mL) showed the least percentage egg hatching (41.7%) compared with the other treatment groups and positive control (albendazole) (45.1%). The aberrations observed in sperm cells were not concentration-dependent and no significant differences were observed in the mean aberrations between the nanoparticulate drug-exposed groups and the negative control (p&gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0045_s_996_w2aab3b7b9b1b6b1aab1c17b4Aa\">\n                    <jats:title id=\"d1987534e30860_w2aab3b7b9b1b6b1aab1c17b4aAa\">Conclusions:<\/jats:title>\n                    <jats:p>\n                      The results confirmed the ovicidal activity of the curcumin-nisin nanoparticulate drug against the\n                      <jats:italic>Fasciola<\/jats:italic>\n                      species. The formulation also showed no toxicity to sperm cells. More robust studies on anti-fascioliasis activity of the drug on adult\n                      <jats:italic>Fasciola<\/jats:italic>\n                      spp. and\n                      <jats:italic>in vivo<\/jats:italic>\n                      and\n                      <jats:italic>in vitro<\/jats:italic>\n                      toxicity studies are recommended.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2017-0045","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T06:01:12Z","timestamp":1507615272000},"page":"73-79","source":"Crossref","is-referenced-by-count":15,"title":["<b>\n                      <i>In vitro<\/i>\n                    <\/b>\n                    ovicidal activity of poly lactic acid curcumin-nisin co-entrapped nanoparticle against\n                    <i>Fasciola<\/i>\n                    spp. eggs and its reproductive toxicity"],"prefix":"10.1515","volume":"29","author":[{"given":"Oyetunde","family":"Oyeyemi","sequence":"first","affiliation":[{"name":"Department of Biological Sciences , University of Medical Sciences , Ondo , Niger ia"},{"name":"Department of Basic Sciences , Babcock University , Ilishan-Remo, Ogun State , Niger ia"},{"name":"Product Development Cell, National Institute of Immunology , Aruna Asaf Ali Marg, New Delhi , India , Phone: +2348163546787"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odunayo","family":"Adegbeyeni","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences , Babcock University , Ilishan-Remo, Ogun State , Niger ia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeoluwa","family":"Oyeyemi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences , University of Medical Sciences , Ondo , Niger ia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairam","family":"Meena","sequence":"additional","affiliation":[{"name":"Product Development Cell, National Institute of Immunology , Aruna Asaf Ali Marg, New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amulya","family":"Panda","sequence":"additional","affiliation":[{"name":"Product Development Cell, National Institute of Immunology , Aruna Asaf Ali Marg, New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"2025121209091742941_j_jbcpp-2017-0045_ref_001_w2aab3b7b9b1b6b1ab1b7b1Aa","unstructured":"Haridy FM, Morsy TA, Gawish NI, Antonios TN, Abdel Gawad AG. 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