{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:26:59Z","timestamp":1765542419400,"version":"3.48.0"},"reference-count":47,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2017-0058_s_999_w2aab2b8c21b1b7b1aab1c15b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Glyphae brevis<\/jats:italic>\n                      leaf is reported in ethnomedicine as a treatment for hepatitis and jaundice; however, no studies have hitherto investigated the mechanistic basis of these claims.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0058_s_998_w2aab2b8c21b1b7b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A hepato-protective role of\n                      <jats:italic>G. brevis<\/jats:italic>\n                      hydromethanolic (GBH) leaf extract was established against carbon tetrachloride (CCl\n                      <jats:sub>4<\/jats:sub>\n                      )-induced hepatotoxicity. Twenty-four hours after a CCl\n                      <jats:sub>4<\/jats:sub>\n                      challenge, rats were sacrificed and serum hematological indices, lipid profile, and biochemical parameters were determined. The antioxidant enzymes parameters (glutathione, catalase, and superoxide dismutase) and lipid peroxidation product (thiobarbituric reactive substances) levels in liver homogenates were evaluated. Changes in the liver cyto-architecture of different treatment groups were also investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0058_s_997_w2aab2b8c21b1b7b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The GBH extract produced no significant impact on weight and hematological indices. Intoxication with CCl\n                      <jats:sub>4<\/jats:sub>\n                      significantly (p&lt;0.001\u20130.05) increased total cholesterol (TC) and low-density lipoproteins (LDL) compared with control rats. Pretreatment with GBH leaf extract significantly reduced triglycerides, TC, and LDL to approaching control levels (p&lt;0.001\u20130.05). The GBH leaf extract significantly alleviated CCl\n                      <jats:sub>4<\/jats:sub>\n                      -induced elevation of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and the CCl\n                      <jats:sub>4<\/jats:sub>\n                      -induced depression of total protein, and albumin. Liver antioxidant parameters were significantly increased in plant extract-treated rats, and this antagonized the pro-oxidant effect of CCl\n                      <jats:sub>4<\/jats:sub>\n                      . Histopathological studies also supported a hepato-protective effect of GBH. Collectively, the GBH leaf extract alleviated the CCl\n                      <jats:sub>4<\/jats:sub>\n                      -induced hepatotoxicity through improvement of innate antioxidant enzyme levels and lipid metabolism and stabilized the hepatocyte cyto-architecture of intoxicated rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0058_s_996_w2aab2b8c21b1b7b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study establishes the ethnomedicinal role of\n                      <jats:italic>G. brevis<\/jats:italic>\n                      leaf in hepatitis and the mechanistic basis of hepato-protection against CCl\n                      <jats:sub>4<\/jats:sub>\n                      -induced hepatotoxicity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2017-0058","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T16:54:30Z","timestamp":1535561670000},"page":"609-619","source":"Crossref","is-referenced-by-count":5,"title":["Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of\n                    <i>Glyphae brevis<\/i>\n                    (Tiliaceae)"],"prefix":"10.1515","volume":"29","author":[{"given":"Lucky Legbosi","family":"Nwidu","sequence":"first","affiliation":[{"name":"Department of Experimental Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences , University of Port Harcourt , East West Road, Choba, P.O. 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