{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:31:15Z","timestamp":1765546275763,"version":"3.48.0"},"reference-count":45,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2017-0061_s_999_w2aab3b7c12b1b6b1aab1c17b1Aa\">\n                    <jats:title id=\"d21360e36218_w2aab3b7c12b1b6b1aab1c17b1aAa\">Background:<\/jats:title>\n                    <jats:p>Zymosan is a fungal cell wall protein-carbohydrate complex that is known to activate inflammatory pathways through the Toll-like receptors and is commonly used to induce fever. Nevertheless, the central mediators that are involved in the zymosan-induced febrile response are only partially known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0061_s_998_w2aab3b7c12b1b6b1aab1c17b2Aa\">\n                    <jats:title id=\"d21360e36226_w2aab3b7c12b1b6b1aab1c17b2aAa\">Methods:<\/jats:title>\n                    <jats:p>The present study evaluated the participation of prostaglandins, substance P, endothelin-1 (ET-1), and endogenous opioids (eOPs) in the zymosan-induced febrile response by using inhibitors and antagonists in male Wistar rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0061_s_997_w2aab3b7c12b1b6b1aab1c17b3Aa\">\n                    <jats:title id=\"d21360e36234_w2aab3b7c12b1b6b1aab1c17b3aAa\">Results:<\/jats:title>\n                    <jats:p>\n                      Both nonselective (indomethacin) and selective (celecoxib) cyclooxygenase inhibitors reduced the febrile response induced by an intraperitoneal (i.p.) injection of zymosan. Indomethacin also blocked the increase in the prostaglandin E\n                      <jats:sub>2<\/jats:sub>\n                      levels in the cerebrospinal fluid. An intracerebroventricular injection of the neurokinin-1, ET\n                      <jats:sub>B<\/jats:sub>\n                      , and \u03bc-opioid receptor antagonists also reduced the febrile response induced by the i.p. injected zymosan. Moreover, the \u03bc-opioid receptor antagonist CTAP also reduced the febrile response induced by intra-articular injection of zymosan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0061_s_996_w2aab3b7c12b1b6b1aab1c17b4Aa\">\n                    <jats:title id=\"d21360e36248_w2aab3b7c12b1b6b1aab1c17b4aAa\">Conclusions:<\/jats:title>\n                    <jats:p>These results demonstrate that prostaglandins, substance P, ET-1, and eOPs are central mediators of the zymosan-induced febrile response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2017-0061","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T06:01:22Z","timestamp":1507183282000},"page":"555-562","source":"Crossref","is-referenced-by-count":9,"title":["Central mediators of the zymosan-induced febrile response"],"prefix":"10.1515","volume":"28","author":[{"given":"Amanda Leite","family":"Bastos-Pereira","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Biological Sciences Sector , Federal University of Paran\u00e1 , Curitiba , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Fraga","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Biological Sciences Sector , Federal University of Paran\u00e1 , Curitiba , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo Alejandro","family":"Dreifuss","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Biological Sciences Sector , Federal University of Paran\u00e1 , Curitiba , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksander Roberto","family":"Zampronio","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Centro Polit\u00e9cnico, Setor de Ci\u00eancias Biol\u00f3gicas , Universidade Federal do Paran\u00e1 , Caixa Postal 19031 , Curitiba, Paran\u00e1, 81530-980 , Brazil , Phone: +55 41 3361-1540, Fax: +55 41 3266-2042"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"2025121209111462298_j_jbcpp-2017-0061_ref_001_w2aab3b7c12b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Li S, Wang Y, Matsumura K, Ballou LR, Morham SG, Blatteis CM. 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