{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:04:47Z","timestamp":1784019887262,"version":"3.55.0"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2017-0155_s_999_w2aab2b8c62b1b7b1aab1c16b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Initial evidences have shown that diabetes mellitus occurs concomitantly with obsessive-compulsive disorder (OCD) symptomatology. Serotonergic psychiatric therapy posits that serotonin is a central character in the management of OCD. Hence, it is worth investigating novel chemical entities affecting the serotonergic system for targeting OCD. An isoflavonoid phytoestrogen, genistein, has been recognized as of great pharmacological value especially for protecting neurodegeneration, depression (serotonin regulation), and diabetes. The effectiveness of genistein pretreatment on the symptoms of OCD in streptozotocin-induced diabetic mice is investigated in this study. We also evaluate the probable involvement of the serotonergic system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0155_s_998_w2aab2b8c62b1b7b1aab1c16b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Groups of diabetic mice were treated with genistein at the dose of 5.0 and 10.0 mg\/kg (intraperitoneal, twice daily, 14 days), and symptoms of OCD were assessed by the marble-burying behavior, in comparison with the standard drug fluoxetine. Neurochemical assessment of the serotonergic ratio 5-hydroxyindole-3-methoxyphenylacetic acid\/5-hydroxytryptamine (5-HIAA\/5-HT) in the cortical region of the brain was performed using HPLC (high-pressure liquid chromatography).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0155_s_997_w2aab2b8c62b1b7b1aab1c16b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chronic treatment with genistein significantly recovered [\n                      <jats:italic>F<\/jats:italic>\n                      (6, 35)=53.00, p&lt;0.0001,\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =0.9008] the symptoms of OCD as assessed by marble burying behavior in normal and diabetic mice. Locomotor performance was not influenced by the diabetic condition or any associated treatment. The turnover of serotonin neurotransmission (5-HIAA\/5-HT) was significantly boosted in the diabetic condition; genistein treatment dragged it [\n                      <jats:italic>F<\/jats:italic>\n                      (6, 35)=35.75, p&lt;0.0001,\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      =0.8597] toward the respective control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0155_s_996_w2aab2b8c62b1b7b1aab1c16b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Genistein supplementation might be a potential therapeutic line for the management and\/or prevention of diabetes-associated OCD symptomatology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2017-0155","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T04:35:56Z","timestamp":1523507756000},"page":"421-425","source":"Crossref","is-referenced-by-count":15,"title":["Improved serotonergic neurotransmission by genistein pretreatment regulates symptoms of obsessive-compulsive disorder in streptozotocin-induced diabetic mice"],"prefix":"10.1515","volume":"29","author":[{"given":"Pradeep","family":"Phadnis","sequence":"first","affiliation":[{"name":"Department of Pharmacology , Bundelkhand Medical College , Sagar, Madhya Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima","family":"Dey Sarkar","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry , Mahatma Gandhi Memorial Medical College , A.B. Road , Indore 452001, Madhya Pradesh , India , Phone: +91 9425077653"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithun Singh","family":"Rajput","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry , Mahatma Gandhi Memorial Medical College , Indore, Madhya Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,3,21]]},"reference":[{"key":"2025121209133006364_j_jbcpp-2017-0155_ref_001_w2aab2b8c62b1b7b1ab2b1b1Aa","unstructured":"American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th ed. Washington DC: American Psychiatric Press, 1994:417."},{"key":"2025121209133006364_j_jbcpp-2017-0155_ref_002_w2aab2b8c62b1b7b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"El Mansari M, Blier P. Mechanisms of action of current and potential pharmacotherapies of obsessive \u2013 compulsive disorder. 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