{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:47:57Z","timestamp":1765540077985,"version":"3.48.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2017-0161_s_999_w2aab2b8c54b1b7b1aab1c15b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Vaccinium myrtillus<\/jats:italic>\n                      leaves are known to be rich in phenols and have been used in traditional medicine as an antidiabetic remedy. This study evaluated the powder extract of\n                      <jats:italic>V. myrtillus<\/jats:italic>\n                      leaves obtained with the use of L-arginine and myo-inositol for anti-obesity and lipid-lowering potential in hamsters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0161_s_998_w2aab2b8c54b1b7b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Standard phytochemical methods were used to determine the total phenolic and total flavonoid contents of the extract. The obesity condition was induced in Syrian hamsters by feeding them with highly palatable fat- and sugar-rich diet (40.3 kcal% fat) for 12 weeks. From the 10th week of diet feeding, the obese hamsters were treated with the powder extract of\n                      <jats:italic>V. myrtillus<\/jats:italic>\n                      leaves (15, 25 and 35 mg\/kg\/day, respectively) and \u201cStyfimol\u201d (6.2 mg\/kg\/day of hydroxycitric acid) as a positive control drug. At the end of the treatment period, the biochemical parameters as well as visceral fat mass were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0161_s_997_w2aab2b8c54b1b7b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Vaccinium myrtillus<\/jats:italic>\n                      leaves powder extract at 25 and 35 mg\/kg\/day caused a significant reduction in body weight gain and visceral fat mass in obese hamsters. Serum triacylglycerols, free fatty acids, total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were also significantly lower. Besides, the hamsters treated with powder extract at 25 and 35 mg\/kg\/day had the closest intact value ratio of high-density lipoprotein cholesterol and LDL-C compared with positive control animals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0161_s_996_w2aab2b8c54b1b7b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The results showed that\n                      <jats:italic>V. myrtillus<\/jats:italic>\n                      leaves powder extract is a promising therapeutic agent for the treatment of obesity and obesity-induced diseases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2017-0161","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T18:16:21Z","timestamp":1532715381000},"page":"697-703","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of anti-obesity and lipid-lowering properties of\n                    <i>Vaccinium myrtillus<\/i>\n                    leaves powder extract in a hamster model"],"prefix":"10.1515","volume":"29","author":[{"given":"Andriy L.","family":"Zagayko","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry , National University of Pharmacy , Kharkiv , Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-0360","authenticated-orcid":false,"given":"Tetiana Ye.","family":"Kolisnyk","sequence":"additional","affiliation":[{"name":"Department of Industrial Technology of Drugs , National University of Pharmacy , Kharkiv , Ukraine , Phone: +380682474033, +380572678852"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena I.","family":"Chumak","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry , National University of Pharmacy , Kharkiv , Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena A.","family":"Ruban","sequence":"additional","affiliation":[{"name":"Department of Industrial Technology of Drugs , National University of Pharmacy , Kharkiv , Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleh M.","family":"Koshovyi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy , National University of Pharmacy , Kharkiv , Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_001_w2aab2b8c54b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Codario RA. Obesity and the metabolic syndrome. In: Codario RA, editor. Type 2 diabetes, pre-diabetes, and the metabolic syndrome. Clifton: Humana Press, 2011:67\u201392.","DOI":"10.1007\/978-1-60327-441-8_5"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_002_w2aab2b8c54b1b7b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci 2014;15:6184\u2013223.","DOI":"10.3390\/ijms15046184"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_003_w2aab2b8c54b1b7b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Zlobine I, Gopal K, Ussher JR. Lipotoxicity in obesity and diabetes-related cardiac dysfunction. Biochim Biophys Acta 2016;1861:1555\u201368.","DOI":"10.1016\/j.bbalip.2016.02.011"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_004_w2aab2b8c54b1b7b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Arca M. Dyslipidemia and cardiovascular risk in obesity. In: Lenzi A, Migliaccio S, Donini L, editors. Multidisciplinary approach to obesity. Cham: Springer, 2015:121\u201330.","DOI":"10.1007\/978-3-319-09045-0_12"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_005_w2aab2b8c54b1b7b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Hanhineva K, T\u00f6rr\u00f6nen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykk\u00e4nen H, et al. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci 2010;11:1365\u2013402.","DOI":"10.3390\/ijms11041365"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_006_w2aab2b8c54b1b7b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Munir KM, Chandrasekaran S, Gao F, Quon MJ. Mechanisms for food polyphenols to ameliorate insulin resistance and endothelial dysfunction: therapeutic implications for diabetes and its cardiovascular complications. Am J Physiol Endocrinol Metab 2013;305:E679\u201386.","DOI":"10.1152\/ajpendo.00377.2013"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_007_w2aab2b8c54b1b7b1ab2b1b7Aa","doi-asserted-by":"crossref","unstructured":"Quideau S, Deffieux D, Douat-Casassus C, Pouys\u00e9gu L. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed Engl 2011;50:586\u2013621.","DOI":"10.1002\/anie.201000044"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_008_w2aab2b8c54b1b7b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Carpene C, Gomez-Zorita S, Deleruyelle S, Carpene MA. Novel strategies for preventing diabetes and obesity complications with natural polyphenols. Curr Med Chem 2015;22:150\u201364.","DOI":"10.2174\/0929867321666140815124052"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_009_w2aab2b8c54b1b7b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Rao RN, Sakariah KK. Lipid-lowering and antiobesity effect of (\u2013)-hydroxycitric acid. Nutr Res 1988;8:209\u201312.","DOI":"10.1016\/S0271-5317(88)80024-1"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_010_w2aab2b8c54b1b7b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Semwal RB, Semwal DK, Vermaak I, Viljoen A. A comprehensive scientific overview of Garcinia cambogia. Fitoterapia 2015;102:134\u201348.","DOI":"10.1016\/j.fitote.2015.02.012"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_011_w2aab2b8c54b1b7b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311\u201322.","DOI":"10.1016\/S0049-3848(96)00195-8"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_012_w2aab2b8c54b1b7b1ab2b1c12Aa","doi-asserted-by":"crossref","unstructured":"Sidorova Y, Shipelin V, Mazo V, Zorin S, Petrov N, Kochetkova A. Hypoglycemic and hypolipidemic effect of Vaccinium myrtillus L. leaf and Phaseolus vulgaris L. seed coat extracts in diabetic rats. Nutrition 2017;41:107\u201312.","DOI":"10.1016\/j.nut.2017.04.010"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_013_w2aab2b8c54b1b7b1ab2b1c13Aa","doi-asserted-by":"crossref","unstructured":"Bljaji\u0107 K, Petlevski R, Vuji\u0107 L, \u010ca\u010di\u0107 A, \u0160o\u0161tari\u0107 N, Jablan J, et al. Chemical composition, antioxidant and \u03b1-glucosidase-inhibiting activities of the aqueous and hydroethanolic extracts of Vaccinium myrtillus leaves. Molecules 2017;22:E703.","DOI":"10.3390\/molecules22050703"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_014_w2aab2b8c54b1b7b1ab2b1c14Aa","unstructured":"McKenna DJ, Jones K, Hughes K. Botanical medicines: the desk reference for major herbal supplements. New York: Haworth Herbal Press, 2002."},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_015_w2aab2b8c54b1b7b1ab2b1c15Aa","unstructured":"Koshovyi OM, Zagayko AL, Kolychev IO, Fylymonenko VP, Komisarenko AM, inventors; National University of Pharmacy, assignee. Method for producing hypoglycemic composition from leaves of blueberry (Vaccinium myrtillus L.). UA patent 111134. March 25, 2016. Ukrainian."},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_016_w2aab2b8c54b1b7b1ab2b1c16Aa","doi-asserted-by":"crossref","unstructured":"Kohli R, Meininger CJ, Haynes TE, Yan W, Self JT, Wu G. Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats. J Nutr 2004;134:600\u20138.","DOI":"10.1093\/jn\/134.3.600"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_017_w2aab2b8c54b1b7b1ab2b1c17Aa","doi-asserted-by":"crossref","unstructured":"Tan B, Li X, Yin Y, Wu Z, Liu C, Tekwe CD, et al. Regulatory roles for L-arginine in reducing white adipose tissue. Front Biosci 2012;17:2237\u201346.","DOI":"10.2741\/4047"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_018_w2aab2b8c54b1b7b1ab2b1c18Aa","doi-asserted-by":"crossref","unstructured":"Ariki R, Hirano A, Arakawa T, Shiraki K. Arginine increases the solubility of alkyl gallates through interaction with the aromatic ring. J Biochem 2011;149:389\u201394.","DOI":"10.1093\/jb\/mvr004"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_019_w2aab2b8c54b1b7b1ab2b1c19Aa","doi-asserted-by":"crossref","unstructured":"Muscogiuri G, Palomba S, Lagan\u00e0 AS, Orio F. Inositols in the treatment of insulin-mediated diseases. Int J Endocrinol 2016;2016:3058393.","DOI":"10.1155\/2016\/3058393"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_020_w2aab2b8c54b1b7b1ab2b1c20Aa","doi-asserted-by":"crossref","unstructured":"Mancini M, Andreassi A, Salvioni M, Pelliccione F, Mantellassi G, Banderali G. D-chiro inositol in improving insulin resistance in obese male children: preliminary data. Int J Endocrinol 2016;2016:8720342.","DOI":"10.1155\/2016\/8720342"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_021_w2aab2b8c54b1b7b1ab2b1c21Aa","unstructured":"Koshovyi OM, Zagayko AL, Kolychev IO, Akhmedov EYu, Komissarenko AN. [Phytochemical study of the dry extract from bilberry leaves]. Azerbaijan Pharm Pharmacother J 2016;1: 18\u201323. Russian."},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_022_w2aab2b8c54b1b7b1ab2b1c22Aa","unstructured":"Ministry of Health of Ukraine. State register of drugs of Ukraine. Informational fund. Available at: http:\/\/www.drlz.kiev.ua. Accessed: 4 Sep 2017. Ukrainian."},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_023_w2aab2b8c54b1b7b1ab2b1c23Aa","unstructured":"European Pharmacopoeia 9th ed. Strasbourg: Council of Europe, 2016."},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_024_w2aab2b8c54b1b7b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Dalb\u00f8ge LS, Pedersen PJ, Hansen G, Fabricius K, Hansen HB, Jelsing J, et al. A hamster model of diet-induced obesity for preclinical evaluation of anti-obesity, anti-diabetic and lipid modulating agents. PLoS One 2015;10:e0135634.","DOI":"10.1371\/journal.pone.0135634"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_025_w2aab2b8c54b1b7b1ab2b1c25Aa","doi-asserted-by":"crossref","unstructured":"Briand F, Thi\u00e9blemont Q, Muzotte E, Sulpice T. High-fat and fructose intake induces insulin resistance, dyslipidemia, and liver steatosis and alters in vivo macrophage-to-feces reverse cholesterol transport in hamsters. J Nutr 2012;142:704\u20139.","DOI":"10.3945\/jn.111.153197"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_026_w2aab2b8c54b1b7b1ab2b1c26Aa","unstructured":"Higa TS, Spinola AV, Fonseca-Alaniz MH, Evangelista FS. Comparison between cafeteria and high-fat diets in the induction of metabolic dysfunction in mice. Int J Physiol Pathophysiol Pharmacol 2014;6:47\u201354."},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_027_w2aab2b8c54b1b7b1ab2b1c27Aa","doi-asserted-by":"crossref","unstructured":"Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 2016;7:27\u201331.","DOI":"10.4103\/0976-0105.177703"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_028_w2aab2b8c54b1b7b1ab2b1c28Aa","doi-asserted-by":"crossref","unstructured":"Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, et al. Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring) 2011;19:1109\u201317.","DOI":"10.1038\/oby.2011.18"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_029_w2aab2b8c54b1b7b1ab2b1c29Aa","doi-asserted-by":"crossref","unstructured":"Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000;21:697\u2013738.","DOI":"10.1210\/er.21.6.697"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_030_w2aab2b8c54b1b7b1ab2b1c30Aa","doi-asserted-by":"crossref","unstructured":"Berings M, Wehlou C, Verrijken A, Deschepper E, Mertens I, Kaufman JM, et al. Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese females. PLoS One 2012;7:e45145.","DOI":"10.1371\/journal.pone.0045145"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_031_w2aab2b8c54b1b7b1ab2b1c31Aa","doi-asserted-by":"crossref","unstructured":"Dillard A, Matthan NR, Lichtenstein AH. Use of hamster as a model to study diet-induced atherosclerosis. Nutr Metab (Lond) 2010;7:89.","DOI":"10.1186\/1743-7075-7-89"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_032_w2aab2b8c54b1b7b1ab2b1c32Aa","doi-asserted-by":"crossref","unstructured":"Cho AS, Jeon SM, Kim MJ, Yeo J, Seo KI, Choi MS, et al. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol 2010;48:937\u201343.","DOI":"10.1016\/j.fct.2010.01.003"},{"key":"2025121209110230451_j_jbcpp-2017-0161_ref_033_w2aab2b8c54b1b7b1ab2b1c33Aa","doi-asserted-by":"crossref","unstructured":"Seo S, Lee MS, Chang E, Shin Y, Oh S, Kim IH, et al. Rutin increases muscle mitochondrial biogenesis with AMPK activation in high-fat diet-induced obese rats. Nutrients 2015;7:8152\u201369.","DOI":"10.3390\/nu7095385"}],"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jbcpp.2018.29.issue-6\/jbcpp-2017-0161\/jbcpp-2017-0161.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2017-0161\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2017-0161\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:44:29Z","timestamp":1765539869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2017-0161\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,27]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,8,8]]},"published-print":{"date-parts":[[2018,11,27]]}},"alternative-id":["10.1515\/jbcpp-2017-0161"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2017-0161","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"type":"electronic","value":"2191-0286"},{"type":"print","value":"0792-6855"}],"subject":[],"published":{"date-parts":[[2018,7,27]]}}}