{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:56:30Z","timestamp":1765540590729,"version":"3.48.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2017-0201_s_999_w2aab3b7c10b1b6b1aab1c17b1Aa\">\n                    <jats:title id=\"d6628e33320_w2aab3b7c10b1b6b1aab1c17b1aAa\">Background:<\/jats:title>\n                    <jats:p>\n                      This study was carried out to determine the blood pressure changes in experimentally\n                      <jats:italic>Trypanosoma brucei brucei<\/jats:italic>\n                      -infected Wistar albino rats and diminazene aceturate-treated rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0201_s_998_w2aab3b7c10b1b6b1aab1c17b2Aa\">\n                    <jats:title id=\"d6628e33331_w2aab3b7c10b1b6b1aab1c17b2aAa\">Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty-four rats were purchased and divided into four groups consisting of six rats each. Control group (CON) received 0.5 mL of distilled water, i.m., infected but not treated group (INF) received 2\u00d710\n                      <jats:sup>6<\/jats:sup>\n                      trypanosome\/mL i.m., infected but diminazene aceturate-treated group (INFDIM) received 2\u00d710\n                      <jats:sup>6<\/jats:sup>\n                      trypanosome\/mL, 3.5 mg\/kg, i.m.) and non-infected but diminazene aceturate-treated group (DIM) received 3.5 mg\/kg, i.m. and served as negative control. The blood pressures were measured using a CODA 2\n                      <jats:sup>\u00ae<\/jats:sup>\n                      non-invasive blood pressure monitor (Kent Scientific, USA). The results were compiled and statistical analysis was done with significance set at p\u22650.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0201_s_997_w2aab3b7c10b1b6b1aab1c17b3Aa\">\n                    <jats:title id=\"d6628e33348_w2aab3b7c10b1b6b1aab1c17b3aAa\">Results:<\/jats:title>\n                    <jats:p>\n                      The values of the blood pressure readings of the\n                      <jats:italic>Trypanosoma<\/jats:italic>\n                      -infected INF (137.0\u00b12.0 mmHg) and diminazene-treated rats INFDIM (125.0\u00b17.5 mmHg) when compared to the control group (168.0\u00b13.0 mmHg) were significantly lower (p\u22640.05) at the end of day 7. The heart rate was also significantly reduced in the INF (403.5\u00b11.5 beats\/min) and DIM (445.0\u00b124 beats\/min) groups of rats when compared with the control group (613.0\u00b12.0 beats\/min) at the end of day 8.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2017-0201_s_996_w2aab3b7c10b1b6b1aab1c17b4Aa\">\n                    <jats:title id=\"d6628e33359_w2aab3b7c10b1b6b1aab1c17b4aAa\">Conclusion:<\/jats:title>\n                    <jats:p>\n                      The findings indicate the significant reduction in blood pressure and heart rates during\n                      <jats:italic>Trypanosoma brucei brucei<\/jats:italic>\n                      infection and with diminazene aceturate administration. Hence, caution should be exercised when treating trypanosome-infected patients with diminazene aceturate.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2017-0201","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T04:47:10Z","timestamp":1523508430000},"page":"265-269","source":"Crossref","is-referenced-by-count":0,"title":["Effects of\n                    <i>Trypanosoma brucei brucei<\/i>\n                    infection and diminazene aceturate administration on the blood pressure, heart rate, and temperature of Wistar albino rats"],"prefix":"10.1515","volume":"29","author":[{"given":"Olushola Emmanuel","family":"Adeleye","sequence":"first","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine , Federal University of Agriculture , Abeokuta, Ogun State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jude Makinde","family":"Ale","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine , Federal University of Agriculture , Abeokuta, Ogun State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuella Olubanke Amope","family":"Sogebi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, College of Veterinary Medicine , Federal University of Agriculture , Abeokuta, Ogun State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladoke A.","family":"Durotoye","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine , Federal University of Agriculture , Abeokuta, Ogun State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adenike Iyabo","family":"Adeleye","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, College of Veterinary Medicine , Federal University of Agriculture , Abeokuta, Ogun State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Olufemi","family":"Adeyemi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics , Olabisi Onabanjo University , Sagamu, Ogun State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny Olufemi","family":"Olukunle","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology , College of Veterinary Medicine , Federal University of Agriculture , Abeokuta, Ogun State, A234 , Nigeria , Phone +2348101846078"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"2025121209143719957_j_jbcpp-2017-0201_ref_001_w2aab3b7c10b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Welbum SC, Picozzi K, Fevre EM, Coleman PG, Odiit M, Carrington M, et al. 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