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Both genetic susceptibilities and acquired deficiencies as a result of alcoholic and non-alcoholic factors are associated with thiamine deficiency or its impaired utilization. WKS is underdiagnosed because of the inconsistent clinical presentation and overlapping of symptoms with other neurological conditions. The identification and individualized treatment of WE based on the etiology is vital to prevent the development of the amnestic state associated with KP in genetically predisposed individuals. Through this review, we bring together the existing data from animal and human models to expound the etiopathogenesis, diagnosis, and therapeutic interventions for WE and KP.<\/jats:p>","DOI":"10.1515\/jbcpp-2018-0075","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T05:01:10Z","timestamp":1538542870000},"page":"153-162","source":"Crossref","is-referenced-by-count":138,"title":["Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis"],"prefix":"10.1515","volume":"30","author":[{"given":"Abin","family":"Chandrakumar","sequence":"first","affiliation":[{"name":"Clinical Research Unit , Children\u2019s Hospital Research Institute of Manitoba , Winnipeg , Canada"},{"name":"Department of Pharmacology and Therapeutics , University of Manitoba , Winnipeg , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseem","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Clinical Research Unit , Children\u2019s Hospital Research Institute of Manitoba , Winnipeg , Canada"},{"name":"Department of Pharmacology and Therapeutics , University of Manitoba , Winnipeg , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert W.","family":"\u2018t Jong","sequence":"additional","affiliation":[{"name":"Clinical Research Unit , Children\u2019s Hospital Research Institute of Manitoba , Winnipeg , Canada"},{"name":"Department of Pharmacology and Therapeutics , University of Manitoba , Winnipeg , Canada"},{"name":"Department of Pediatrics , University of Manitoba , Winnipeg , Canada , Phone: +1 204 480 1328, Fax: +1 204 789 3907"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"2025121209104729498_j_jbcpp-2018-0075_ref_001_w2aab3b8c83b1b7b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Hoyumpa AM. 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