{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:05:56Z","timestamp":1781535956710,"version":"3.54.5"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2018-0161_s_999_w2aab3b7c14b1b6b1aab1c15b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Short-term memory impairment is a neurodegenerative disease associated with oxidative stress.\n                      <jats:italic>Bryophyllum pinnatum<\/jats:italic>\n                      (Lam.) Oken of the family Crassulaceae is traditionally used in the treatment of diseases, such as cough, wounds, and kidney diseases. This study evaluates the effect of the aqueous extract of\n                      <jats:italic>B. pinnatum<\/jats:italic>\n                      (AEBP) leaves on acetylcholinesterase activity in carbon tetrachloride (CCl\n                      <jats:sub>4<\/jats:sub>\n                      )-induced short-term memory impairment in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2018-0161_s_998_w2aab3b7c14b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty male Wistar albino rats were used in this study and were divided into six groups (n=5). Group I served as control, group II rats were induced with CCl\n                      <jats:sub>4<\/jats:sub>\n                      , while groups III\u2013V animals were pretreated with silymarin (25 mg\/kg body weight), 25 and 50 mg\/kg body weight AEBP leaves, respectively, once daily by oral gavage for 14 days prior to a single intraperitoneal injection of CCl\n                      <jats:sub>4<\/jats:sub>\n                      . Animals in group VI received 50 mg\/kg body weight AEBP only by oral gavage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2018-0161_s_997_w2aab3b7c14b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Administration of carbon tetrachloride significantly increased (p&lt;0.05) spontaneous alternation and locomotor function in rats when compared with the control group. Also, the levels of acetylcholinesterase, adenosine deaminase, and malondialdehyde were increased in CCl\n                      <jats:sub>4<\/jats:sub>\n                      -administered rats, with reduction in both enzymatic and nonenzymatic antioxidant levels. However, pretreatment of rats with AEBP leaves, at tested doses, prevented these changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2018-0161_s_996_w2aab3b7c14b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The increased antioxidant status and the inhibition of acetylcholinesterase activity show that AEBP leaves improve learning memory and stabilizes memory impairment caused by CCl\n                      <jats:sub>4<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2018-0161","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T05:02:30Z","timestamp":1567918950000},"source":"Crossref","is-referenced-by-count":12,"title":["Prevention of short-term memory impairment by\n                    <i>Bryophyllum pinnatum<\/i>\n                    (Lam.) Oken and its effect on acetylcholinesterase changes in CCl\n                    <sub>4<\/sub>\n                    -induced neurotoxicity in rats"],"prefix":"10.1515","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-4611","authenticated-orcid":false,"given":"Scholastica Onyebuchi","family":"Anadozie","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences, Biochemistry unit , Afe Babalola University , Km 8.5 Afe Babalola way, PMB 5454 , Ado-Ekiti, Ekiti State , Nigeria , Phone: +234 813 3254 737; +27 64 63 180 64"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Ayodele","family":"Akinyemi","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Biochemistry unit , Afe Babalola University , Ado-Ekiti , Ekiti State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusola Bolaji","family":"Adewale","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Biochemistry unit , Afe Babalola University , Ado-Ekiti , Ekiti State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy Chinwe","family":"Isitua","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Microbiology unit , Afe Babalola University , Ado-Ekiti , Ekiti State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,9,9]]},"reference":[{"key":"2025121209140541109_j_jbcpp-2018-0161_ref_001_w2aab3b7c14b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: Carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003;33:105\u201336.","DOI":"10.1080\/713611034"},{"key":"2025121209140541109_j_jbcpp-2018-0161_ref_002_w2aab3b7c14b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Alkreathy HM, Khan RA, Khan MR, Sahreen S. CCl4 induced genotoxicity and DNA oxidative damages in rats: hepatoprotective effect of Sonchus arvensis. BMC Complement Altern Med 2014;14:452.","DOI":"10.1186\/1472-6882-14-452"},{"key":"2025121209140541109_j_jbcpp-2018-0161_ref_003_w2aab3b7c14b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Wallace AD. Toxic endpoints in the study of human exposure to environmental chemicals. Prog Mol Biol Transl Sci 2012;112:89\u2013115.","DOI":"10.1016\/B978-0-12-415813-9.00004-0"},{"key":"2025121209140541109_j_jbcpp-2018-0161_ref_004_w2aab3b7c14b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Ware GW. Carbon tetrachloride. 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