{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:25:14Z","timestamp":1765542314795,"version":"3.48.0"},"reference-count":57,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2018-0175_s_999_w2aab3b8c24b1b7b1aab1c14b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In traditional medicine,\n                      <jats:italic>Allium cepa<\/jats:italic>\n                      Linnaeus is used for the treatment of several disease conditions. Whilst reports abound on the effects of several cultivars of\n                      <jats:italic>A. cepa<\/jats:italic>\n                      L on biochemical parameters, similar information on the red cultivar is scarce. This study examines the effects of the methanol extract of the red cultivar\n                      <jats:italic>A. cepa<\/jats:italic>\n                      L on some serum biochemical parameters in experimental Wistar rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2018-0175_s_998_w2aab3b8c24b1b7b1aab1c14b2Aa\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Fifty-five Wistar rats were divided into three groups (A, B and C), which include 25, 25 and 5 rats, respectively. The rats in Groups A and B were sub-divided into 5 groups of 5 rats. Each rat was administered a certain dose of methanol extract of the red cultivar\n                      <jats:italic>A. cepa<\/jats:italic>\n                      L for 14 days (Group A) or 28 days (Group B). Group C rats served as the control and were administered with distilled water (10 mL\/kg).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2018-0175_s_997_w2aab3b8c24b1b7b1aab1c14b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>A. cepa<\/jats:italic>\n                      L administration resulted in dyslipidaemia, hyponatremia, hypokalaemia and hyperchloraemia; a significant (p &lt; 0.05) decrease in hepatic enzymes and a significant (p &lt; 0.05) increase in serum bicarbonate, bilirubin and its fractions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2018-0175_s_996_w2aab3b8c24b1b7b1aab1c14b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These biochemical results indicate that the excessive and prolonged medicinal consumption of\n                      <jats:italic>A. cepa<\/jats:italic>\n                      L products beyond 7 days may induce moderate hepatic injury and mild renal dysfunction and may complicate disease conditions, such as hypertension and diabetes. Thus, in order to minimize its toxic effects, it is recommended that\n                      <jats:italic>A. cepa<\/jats:italic>\n                      L products should not be used for more than seven consecutive days or beyond a dosage of 90 mg\/kg.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2018-0175","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T04:03:13Z","timestamp":1575432193000},"source":"Crossref","is-referenced-by-count":4,"title":["Effect of the methanol extract of the red cultivar\n                    <i>Allium cepa<\/i>\n                    L. on the serum biochemistry and electrolytes of rats following sub-chronic oral administration"],"prefix":"10.1515","volume":"31","author":[{"given":"Adeoye Joshua","family":"Oyewusi","sequence":"first","affiliation":[{"name":"Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine , Federal University of Agriculture , Abeokuta, Ogun state , Nigeria , Phone no.:+234 8036676864"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olayinka A.","family":"Oridupa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology , University of Ibadan , Ibadan , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adebowale B.","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology , University of Ibadan , Ibadan , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibironke K.","family":"Oyewusi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Surgery , College of Veterinary Medicine , Federal University of Agriculture , Abeokuta , Ogun state , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa F.","family":"Mshelbwala","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology , College of Veterinary Medicine , Federal University of Agriculture , Abeokuta , Ogun state , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_001_w2aab3b8c24b1b7b1ab2b1b1Aa","unstructured":"Eric B. Garlic and other alliums: the lore and the science. Cambridge: Royal Society of Chemistry, 2010."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_002_w2aab3b8c24b1b7b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Shon MY, Choi SD, Kahng GG, Nam SH, Sung NJ. Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions. Food Chem Toxicol 2004;42:659\u201366.","DOI":"10.1016\/j.fct.2003.12.002"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_003_w2aab3b8c24b1b7b1ab2b1b3Aa","unstructured":"Nadkarni KM. Indian material medica, Bombay popular Prakashan, Bombay Indian material medica, 3rd ed., Bombay, 1982;1:63\u201365."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_004_w2aab3b8c24b1b7b1ab2b1b4Aa","unstructured":"Ogbole OO, Adebayo AG, Edith OA. Ethnobotanical survey of plants used in treatment of inflammatory diseases in ogun state of Nigeria. Eur J Sci Res 2010;43:183\u201391."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_005_w2aab3b8c24b1b7b1ab2b1b5Aa","unstructured":"Borborah K, Dutta B, Borthakur SK. Traditional uses of Allium cepa L. species from North East India with special reference totheir pharmacological activities: review article. Am J Phytomed Clin Ther 2014;2:1037\u201351."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_006_w2aab3b8c24b1b7b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Rao AS, Reddy SG, Babu PP, Reddy AR. The antioxidant and antiproliferative activities of methanolic extracts from Njavara rice bran. BMC Complem Altern Med 2010;10:4.","DOI":"10.1186\/1472-6882-10-4"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_007_w2aab3b8c24b1b7b1ab2b1b7Aa","doi-asserted-by":"crossref","unstructured":"Shokoohi M, Madarek EO, Khaki A, Shoorei H, Khaki AA, Soltani M, et al. Investigating the effects of onion juice on male fertility factors and pregnancy rate after testicular torsion\/detorsion by intrauterine insemination method. Int J Women\u2019s Health Reprod Sci 2018;6:499\u2013505.","DOI":"10.15296\/ijwhr.2018.82"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_008_w2aab3b8c24b1b7b1ab2b1b8Aa","unstructured":"Anita C. Side effects of eating onions. The Livestrong Foundation. livestrong.com, 2011."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_009_w2aab3b8c24b1b7b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Guitart R, Mateu C, Lopezi AA, Alberola J. Heinz body anaemia in two dogs after Catalan spring A. cepa (\u201ccalcot\u201d) ingestion: a case reports. Veterinarni Medicina 2008;53:392\u20135.","DOI":"10.17221\/1990-VETMED"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_010_w2aab3b8c24b1b7b1ab2b1c10Aa","unstructured":"Talcott PA. Propyl disulfide. In: Plumlee KH, editor. Clinical veterinary toxicology. St. Louis: Mosby, 2004, 408\u2013410."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_011_w2aab3b8c24b1b7b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Sebastian MM. Roll pathology in diagnosis. In: Gupta RC, editor. Veterinary Toxicology. New York: Academic Press, 2007, 1100\u20131136.","DOI":"10.1016\/B978-012370467-2\/50187-5"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_012_w2aab3b8c24b1b7b1ab2b1c12Aa","unstructured":"Oyewusi JA, Saba AB, Olukunle JO. Phytochemical, elemental and acute toxic effects of methanol extract of A. cepa L bulbs in Wista albino rats experimentally pre-exposed and rested for a week. Vom J Vet Sci 2015;10:65\u201374."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_013_w2aab3b8c24b1b7b1ab2b1c13Aa","unstructured":"Montgomery M. Side effects of eating A. cepas. www.Livestrong.com. Article No 2013; 546291."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_014_w2aab3b8c24b1b7b1ab2b1c14Aa","doi-asserted-by":"crossref","unstructured":"Dontas IA, Marinou KA, Iliopoulos D, Tsantila N, Agrogiannis G, Papalois A, et al. Changes of blood biochemistry in the rabbit animal model in atherosclerosis research; a time or stress-effect. Lipids Health Dis 2011;10:139.","DOI":"10.1186\/1476-511X-10-139"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_015_w2aab3b8c24b1b7b1ab2b1c15Aa","doi-asserted-by":"crossref","unstructured":"Xie L, Xu F, Liu S, Ji Y, Zhou Q, Wu Q, et al. Age and sex-based hematological and biochemical parameters for macacafascicularis. PLoS One 2013;8:1\u20138.","DOI":"10.1371\/journal.pone.0064892"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_016_w2aab3b8c24b1b7b1ab2b1c16Aa","doi-asserted-by":"crossref","unstructured":"Ugochukwu NS, Babady NE, Cobourne M, Gasset SR. The effect of Gongrone malatifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats. J Biosci 2003;28:1\u20135.","DOI":"10.1007\/BF02970124"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_017_w2aab3b8c24b1b7b1ab2b1c17Aa","doi-asserted-by":"crossref","unstructured":"Farrugia A. Albumin usage in clinical medicine: tradition or therapeutic? Transfus Med Rev 2010;24:53\u201363.","DOI":"10.1016\/j.tmrv.2009.09.005"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_018_w2aab3b8c24b1b7b1ab2b1c18Aa","doi-asserted-by":"crossref","unstructured":"Anderson NL, Anderson NG. High resolution two dimentional electrophoresis of human plasma protein. Proc Natl Acad Sci 1977;74:5421\u20135.","DOI":"10.1073\/pnas.74.12.5421"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_019_w2aab3b8c24b1b7b1ab2b1c19Aa","doi-asserted-by":"crossref","unstructured":"Giannini EG, Testa R, Savarino V. Liver enzyme alteration: a guide for clinicians. Can Med Assoc J 2005;172:367\u201379.","DOI":"10.1503\/cmaj.1040752"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_020_w2aab3b8c24b1b7b1ab2b1c20Aa","unstructured":"Uduak AI, Mbeh UE. Effect of the oral administration of Allium cepa and Allium sativum on some serum enzymes of normal and iodine treated albino Wistar rats. Ann Biol Res 2013;4:226\u2013231."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_021_w2aab3b8c24b1b7b1ab2b1c21Aa","doi-asserted-by":"crossref","unstructured":"Rej R. Aminotransferases in disease. Clin Lab Med 1989;9:667\u201387.","DOI":"10.1016\/S0272-2712(18)30598-5"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_022_w2aab3b8c24b1b7b1ab2b1c22Aa","unstructured":"Ruethalo K. VCA quality care pet adoption insurance pet care. Los Angeles: VCA Antech Inc., 2008."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_023_w2aab3b8c24b1b7b1ab2b1c23Aa","doi-asserted-by":"crossref","unstructured":"Sedlak TW, Saleh M, Higginson DS, Paul BD, Juluri KR, Snyder SH. Bilirubin and glutathione have complementary antioxidant and cytoprotective roles. Proc Natl Acad Sci 2009;106:5171\u20136.","DOI":"10.1073\/pnas.0813132106"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_024_w2aab3b8c24b1b7b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Shapiro SM. Bilirubin toxicity in the developing nervous system. Pediatr Neurol 2003;29:410\u201321.","DOI":"10.1016\/j.pediatrneurol.2003.09.011"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_025_w2aab3b8c24b1b7b1ab2b1c25Aa","unstructured":"Knapp AA, Metterville DR, Co PT, Prosser LA, Perrin JM. Evidence review: neonatal hyperbilirubinemia. Prepared For: Maternal and Child Health Bureau Version: January 05, 2012."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_026_w2aab3b8c24b1b7b1ab2b1c26Aa","doi-asserted-by":"crossref","unstructured":"Arora EK, Sharma V, Khurana A, Manchanda A, Sahani DK, Abraham S, et al. Phytochemical analysis and evaluation of antioxidant potential of ethanol extract of Allium cepa and ultra-high homoeopathic dilutions available in the market: a comparative study. Indian J Res Homoeopathy 2017;11:88\u201396.","DOI":"10.4103\/ijrh.ijrh_13_17"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_027_w2aab3b8c24b1b7b1ab2b1c27Aa","doi-asserted-by":"crossref","unstructured":"Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499\u2013502.","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_028_w2aab3b8c24b1b7b1ab2b1c28Aa","doi-asserted-by":"crossref","unstructured":"Weichselbaum TE. An accurate and rapid method for the determination of proteins in small amounts of blood serum and plasma. Am J Clin Pathol Tech 1946;10:40\u20139.","DOI":"10.1093\/ajcp\/16.3_ts.40"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_029_w2aab3b8c24b1b7b1ab2b1c29Aa","doi-asserted-by":"crossref","unstructured":"Schmidt E, Schmidt FW. Determination of serum GOT and GPT. Enzymologia Biologica Clinica 1963;3:1\u201352.","DOI":"10.1159\/000458038"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_030_w2aab3b8c24b1b7b1ab2b1c30Aa","doi-asserted-by":"crossref","unstructured":"Hausamen TU, Helger R, Rick W, Gross W. Optimal conditions for the determination of serum alkaline phosphatase by a new kinetic method. Clinical Chim Acta 1967;15:241.","DOI":"10.1016\/0009-8981(67)90060-5"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_031_w2aab3b8c24b1b7b1ab2b1c31Aa","doi-asserted-by":"crossref","unstructured":"Maruna RF, Trinder P. Determination of serum sodium by the magnesium uranyl acetate. Clin Chem Acta 1958;2:581\u201385.","DOI":"10.1016\/0009-8981(57)90064-5"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_032_w2aab3b8c24b1b7b1ab2b1c32Aa","unstructured":"Baker FJ, Silverton RE. Introduction to medical laboratory technology, 6th ed. UK: Butterworth and co-publishers limited, 1985:243\u2013302."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_033_w2aab3b8c24b1b7b1ab2b1c33Aa","unstructured":"Ann P. The effects of high cholesterol on the body. Reviewed by George Krucik. Health line: August 25, 2014."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_034_w2aab3b8c24b1b7b1ab2b1c34Aa","doi-asserted-by":"crossref","unstructured":"Schaefer EJ. Lipoproteins, nutrition, and heart disease. Am J Clin Nutr 2002;75:191\u2013212.","DOI":"10.1093\/ajcn\/75.2.191"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_035_w2aab3b8c24b1b7b1ab2b1c35Aa","doi-asserted-by":"crossref","unstructured":"Oyewusi JA, Oridupa OA, Saba AB, Oni O, Oyewusi IK, Mshelbwala MF. Assessment of cardiotoxic potential of methanol extract of red cultivar Allium cepa. Sokoto J Vet Sci 2017;15:69\u201377.","DOI":"10.4314\/sokjvs.v15i3.10"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_036_w2aab3b8c24b1b7b1ab2b1c36Aa","doi-asserted-by":"crossref","unstructured":"Ostrowska E, Gabler NK, Sterling SJ, Tatham BG, Jones RB, Eagling DR, et al. Consumption of brown A. cepa L (Allium cepa var. cavalier and var. destiny) moderately modulates blood lipids, haematological and haemostatic variables in healthy pigs. Br J Nutr 2004;91:211\u20138.","DOI":"10.1079\/BJN20031036"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_037_w2aab3b8c24b1b7b1ab2b1c37Aa","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Pe\u00f1a D, Angulo J, Vallejo S, Colina-Coca C, de Ancos B, S\u00e1nchez-Ferrer CF, et al. High-cholesterol diet enriched with onion affects endothelium-dependent relaxation and NADPH oxidase activity in mesenteric microvessels from Wistar rats. Nutr Metabol 2014;11:57.","DOI":"10.1186\/1743-7075-11-57"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_038_w2aab3b8c24b1b7b1ab2b1c38Aa","doi-asserted-by":"crossref","unstructured":"Bertholf LB. Protein and albumin. Lab Med 2014;45:25\u201341.","DOI":"10.1309\/LMKRNRGW5J03APZQ"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_039_w2aab3b8c24b1b7b1ab2b1c39Aa","doi-asserted-by":"crossref","unstructured":"Ujowundu CO, Okoye HN, Nwaoguikpe RN, Belonwu DC, Igwe KO, Ujowundu FN. Hepatoprotective effects of crude extracts of tomato and A. cepa L in rats exposed to locally processed beef. Int J Biochem Res Rev 2014;4:193\u2013203.","DOI":"10.9734\/IJBCRR\/2014\/7353"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_040_w2aab3b8c24b1b7b1ab2b1c40Aa","unstructured":"Maddison J. Diagnosing liver disease in dogs: what do the tests really mean? World Small Animal Veterinary Association World Congress Proceedings, 2001."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_041_w2aab3b8c24b1b7b1ab2b1c41Aa","unstructured":"Willard M, Tvedten H. Small animal clinical diagnosis by laboratory methods, 4th ed. St. Louis, MO: Elsevier\/Saunders, 2004;236."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_042_w2aab3b8c24b1b7b1ab2b1c42Aa","doi-asserted-by":"crossref","unstructured":"Nyblom H, Berggren U, Balldin J, Olsson R. High AST\/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking. Alcohol 2004;39:336\u20139.","DOI":"10.1093\/alcalc\/agh074"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_043_w2aab3b8c24b1b7b1ab2b1c43Aa","unstructured":"Maria S, Maite LG, Javier L, Mercedes G, Lucia F, Carlos L. Diagnostic accuracy of icteric index to detect abnormal total bilirubin values. J Clin Pathol 2012;2012:1\u20136."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_044_w2aab3b8c24b1b7b1ab2b1c44Aa","doi-asserted-by":"crossref","unstructured":"Al-Salahy MB. Some physiological studies on the effect of A. cepa L and garlic juices on the fish, Clariaslazera. Fish Physiol Biochem 2002;27:129\u201342.","DOI":"10.1023\/B:FISH.0000021913.60189.76"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_045_w2aab3b8c24b1b7b1ab2b1c45Aa","unstructured":"Jason N. Indicators of liver diseases. Marietta Ga, Banfield Hospital 2008;0508:24\u201333."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_046_w2aab3b8c24b1b7b1ab2b1c46Aa","doi-asserted-by":"crossref","unstructured":"Samson ES, Olasunkanmi AK, Joel JS, Alfred EF. Haematological and hepatotoxic potential of Allium cepa L and Allium sativum extracts in rats. Eur J Med Plants 2012;2:290\u2013307.","DOI":"10.9734\/EJMP\/2012\/1517"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_047_w2aab3b8c24b1b7b1ab2b1c47Aa","unstructured":"Francis DH. Colibacillosis in pigs and its diagnosis. Swine Health Prod 1999;7:241\u20134."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_048_w2aab3b8c24b1b7b1ab2b1c48Aa","doi-asserted-by":"crossref","unstructured":"Martha T, Majed AA, Tanuja B, Jassim MA, Mohammed A, Muslim A. Effects of aqueous extract of A. cepa L on the liver and lung of rats. J Ethnopharmacol 1998;61:91\u20139.","DOI":"10.1016\/S0378-8741(98)00004-X"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_049_w2aab3b8c24b1b7b1ab2b1c49Aa","doi-asserted-by":"crossref","unstructured":"Pohl HR, Wheeler JS, Murray HE. Chapter 2. Sodium and potassium in health and disease. In: Sigel A, Sigel H, Sigel RK, editors. Interrelations between essential metal ions and human diseases. Metal Ions in Life Sciences, 2013;13:29\u201347.","DOI":"10.1007\/978-94-007-7500-8_2"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_050_w2aab3b8c24b1b7b1ab2b1c50Aa","unstructured":"Clausen MJ, Poulsen H. Chapter 3 sodium\/potassium homeostasis in the cell. In: Banci L, Editor. Metallomics and the cell. Metal ions in life sciences. 2013;12. Springer. ISBN 978-94-007-5560-4. doi:10.1007\/978-94-007-5561-1_3. electronic-book ISBN 978-94-007-5561-1 ISSN 1559-0836 electronic-ISSN 1868-0402."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_051_w2aab3b8c24b1b7b1ab2b1c51Aa","unstructured":"Korkmaz I, G\u00fcven FM, Eren SH, Beydilli I, Yildirim B, Aktas C, et al. Baseline characteristics and the association between hyponatraemia and pulmonary embolism prognosis. J Pak Med Assoc 2013;63:331\u20135."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_052_w2aab3b8c24b1b7b1ab2b1c52Aa","unstructured":"Ayelagbe OG, Adele AS. Effect of Allium cepa supplemented diets on plasma glucose, electrolytes and renal histology of streptozotocin-induced diabetic rats. J Pharm Biol Sci. 2015;10:25\u201332."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_053_w2aab3b8c24b1b7b1ab2b1c53Aa","doi-asserted-by":"crossref","unstructured":"Hansen PB, Jensen BL, Skott O. Chloride regulates afferent arteriolar contraction in response to depolarization. Hypertension 1998;32:1066\u201370.","DOI":"10.1161\/01.HYP.32.6.1066"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_054_w2aab3b8c24b1b7b1ab2b1c54Aa","doi-asserted-by":"crossref","unstructured":"Krieg BJ, Taghavi SM, Amidon GL, Amidon GE. In vivo predictive dissolution: transport analysis of the CO2, bicarbonate in vivo buffer system. J Pharm Sci 2014;103:3473\u201390.","DOI":"10.1002\/jps.24108"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_055_w2aab3b8c24b1b7b1ab2b1c55Aa","unstructured":"Adrian OH. BUN and Creatinine. In: Walker HK, Hall WD, Hurst JW, editors. Clinical methods: the history, physical, and laboratory examinations. Chapter 193, 3rd ed. Butterworth Publishers, a division of Reed Publishing. Boston: Butterworth, 1990."},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_056_w2aab3b8c24b1b7b1ab2b1c56Aa","doi-asserted-by":"crossref","unstructured":"Gharadaghi Y, Shojaee S, Khaki A, Fathiazad F, Khaki AF, Ghdamkheir E, et al. Antiprotozoal effect of Allium cepa on acute renal failure caused by Toxoplasma gondii. Afr J Pharm Pharmacol 2012;6:771\u20137.","DOI":"10.5897\/AJPP12.086"},{"key":"2025121209222750677_j_jbcpp-2018-0175_ref_057_w2aab3b8c24b1b7b1ab2b1c57Aa","unstructured":"Ola-Mudathir KF, Maduagwu EN. Antioxidant effects of methanol extract of Allium cepalinn on cyanide-induced renal toxicity in male wistar rats. Niger J Physiol Sci 2014;29:147\u2013151."}],"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jbcpp\/ahead-of-print\/article-10.1515-jbcpp-2018-0175\/article-10.1515-jbcpp-2018-0175.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2018-0175\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2018-0175\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:20:47Z","timestamp":1765542047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2018-0175\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,4]]},"references-count":57,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,1,11]]},"published-print":{"date-parts":[[2020,3,26]]}},"alternative-id":["10.1515\/jbcpp-2018-0175"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2018-0175","relation":{},"ISSN":["2191-0286"],"issn-type":[{"type":"electronic","value":"2191-0286"}],"subject":[],"published":{"date-parts":[[2019,12,4]]},"article-number":"20180175"}}