{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:40:41Z","timestamp":1792075241491,"version":"4.4.0"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"5","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2019-0108_s_999_w2aab3b7c13b1b6b1aab1c13b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The fractions of\n                      <jats:italic>Corchorus olitorius<\/jats:italic>\n                      leaf (COLF) were evaluated against oxidative stress, inflammation and apoptosis in isoproterenol (ISO)-induced myocardial injury (MI) Wistar rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0108_s_998_w2aab3b7c13b1b6b1aab1c13b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>n<\/jats:italic>\n                      -hexane, dichloromethane, ethylacetate and ethanol fractions were obtained from COLF extract. Male Wistar strains were randomly grouped into 11 groups (n = 6 in each group), which comprises normal control group, MI control group, 4 fraction groups with two doses (50 and 100 mg\/kg) and enalapril (10 mg\/kg). The sera were obtained for biochemical studies like AOPP (advance oxidized protein product), CRP (C-reactive protein), LDH (lactate dehydrogenase), CKMB (creatine kinase-MB) and myocardial tissue obtained for GSH, p65NF\n                      <jats:sub>k<\/jats:sub>\n                      B, bax, bcl2, p53 and p65NF\n                      <jats:sub>k<\/jats:sub>\n                      B assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0108_s_997_w2aab3b7c13b1b6b1aab1c13b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The subcutaneous administration of ISO increased the serum level of CRP, LDH and CKMB significantly (p &lt; 0.05) and decreased serum AOPP, tissue GSH and p65NF\n                      <jats:sub>k<\/jats:sub>\n                      B (p &lt; 0.05) in the infarction control rats. Pretreatment with COLF and enalapril increased the tissue GSH and p65NF\n                      <jats:sub>k<\/jats:sub>\n                      B levels (p &lt; 0.05) and significantly reduced serum CRP, AOPP, LDH and CKMB. The dichloromethane fraction (CODCM) being the most active was chosen to evaluate the anti-apoptotic effect. CODCM (50 and 100 mg\/kg) and enalapril showed a significant (p &lt; 0.05) effect through severe expression of p65NF\n                      <jats:sub>k<\/jats:sub>\n                      B, which correlates with increased bcl2 protein expression, decreased bax protein and p53 expression. Gas chromatography mass spectrometry revealed the presence of 26 compounds in CODCM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0108_s_996_w2aab3b7c13b1b6b1aab1c13b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      From the present study, COLF protected the myocardial tissue against ischemic injury in rats probably via the p65NF\n                      <jats:sub>k<\/jats:sub>\n                      B-dependent anti-apoptotic pathway and attenuation of pro-inflammatory marker level.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2019-0108","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T11:48:24Z","timestamp":1590493704000},"source":"Crossref","is-referenced-by-count":14,"title":["Protective effects and chemical composition of\n                    <i>Corchorus olitorius<\/i>\n                    leaf fractions against isoproterenol-induced myocardial injury through p65NF\n                    <sub>k<\/sub>\n                    B-dependent anti-apoptotic pathway in rats"],"prefix":"10.1515","volume":"31","author":[{"given":"Babatunde","family":"Alabi","sequence":"first","affiliation":[{"name":"Faculty of Basic Medical Science, University of Ibadan , Department of Pharmacology and Therapeutics , Oyo State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temidayo","family":"Omobowale","sequence":"additional","affiliation":[{"name":"University of Ibadan , Department of Veterinary Medicine , Oyo State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Badejo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics , Faculty of Basic Medical Science, University of Ibadan , Oyo State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeolu","family":"Adedapo","sequence":"additional","affiliation":[{"name":"University of Ibadan , Department of Veterinary Pharmacology & Toxicology , Oyo State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwole","family":"Fagbemi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics , Faculty of Basic Medical Science, University of Ibadan , Oyo State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olugbenga","family":"Iwalewa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics , Faculty of Basic Medical Science, University of Ibadan , Oyo State , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_001_w2aab3b7c13b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Ramon R, Matias L, Felipe F, Daniel H. Molecular basis of cardioprotective effect of antioxidant vitamins in myocardial infarction. Biomed Res Int 2013;43:7613.","DOI":"10.1155\/2013\/437613"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_002_w2aab3b7c13b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Julian T, Joseph M, Clarissa G, Luciano A, Alexander T, Gerald S, et al. Acute myocardial infarction in Sub-saharan Africa: need for data. PLoS One 2014;9:5\u201311.","DOI":"10.1371\/journal.pone.0096688"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_003_w2aab3b7c13b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Thomas A, Asaf B, Shuchi A, Shafika A, Adrianna M. Growing epidemic of coronary heart disease in low- and middle-income countries. Curr Prob Cardiol 2010;35:72\u2013115.","DOI":"10.1016\/j.cpcardiol.2009.10.002"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_004_w2aab3b7c13b1b6b1ab2b1b4Aa","unstructured":"Adewole IF. Reversing high incidence of heart diseases deaths: world heart day. University College Hospital Workshop Publication, 2017:19."},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_005_w2aab3b7c13b1b6b1ab2b1b5Aa","unstructured":"Leeder S. A race against time: the challenge of cardiovascular disease in developing countries. New York: Trustees of Columbia University, 2004."},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_006_w2aab3b7c13b1b6b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Yue-tao L, Hong-mei J, Xing C, Gang D, Hong-wu Z, Zhong-Mei Z. The metabolic disturbances of isoproterenol induced myocardial infarction in rats based on a tissue targeted metabonomics. J Mol Biosyst 2013;9:2823\u201334.","DOI":"10.1039\/c3mb70222g"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_007_w2aab3b7c13b1b6b1ab2b1b7Aa","doi-asserted-by":"crossref","unstructured":"Cleutjens JP, Blankesteijn WM, Daemen MJ, Smits JF. The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions. Cardiovasc Res 1999;44:232\u201341.","DOI":"10.1016\/S0008-6363(99)00212-6"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_008_w2aab3b7c13b1b6b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Haunstetter A, Izumo S. Apoptosis; basic mechanisms and implications for cardiovascular disease. Circ Res 1998;82:1111\u201329.","DOI":"10.1161\/01.RES.82.11.1111"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_009_w2aab3b7c13b1b6b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"Chenguang F, Jusan Y, Engelhardt F. Temporal pattern of NF\u03baB activation influences apoptotic cell fate in a stimuli-dependent fashion. J Cell Sci 2002;115:4843\u201353.","DOI":"10.1242\/jcs.00151"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_010_w2aab3b7c13b1b6b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Scherer DC, Brockman JA, Chen Z, Maniatis T, Ballard DW. Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci 1995;11259\u201363.","DOI":"10.1073\/pnas.92.24.11259"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_011_w2aab3b7c13b1b6b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997;387:299\u2013303.","DOI":"10.1038\/387299a0"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_012_w2aab3b7c13b1b6b1ab2b1c12Aa","doi-asserted-by":"crossref","unstructured":"Vousden KH, Lu X. Live or let die: the cell\u2019s response to p53. Nat Rev Cancer 2002;2:594\u2013604.","DOI":"10.1038\/nrc864"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_013_w2aab3b7c13b1b6b1ab2b1c13Aa","doi-asserted-by":"crossref","unstructured":"Mavengahama S, McLachlan MW. The role of wild vegetable species in household food security in maize based subsistence cropping systems. Food Secur 2013;5:227\u201333.","DOI":"10.1007\/s12571-013-0243-2"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_014_w2aab3b7c13b1b6b1ab2b1c14Aa","unstructured":"Denton L. A review of Corchorus olitorius in Nigeria. Workshop on African indigenous vegetables 1997; Limbe, Cameroon. pp 25\u201330. Workshop papers. ODA."},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_015_w2aab3b7c13b1b6b1ab2b1c15Aa","unstructured":"Fondio L, Grubben GJ. Corchorus olitorius L. Vegetables\/L\u00e9gumes. [CD-Rom] 2004. PROTA, Wageningen, Netherlands."},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_016_w2aab3b7c13b1b6b1ab2b1c16Aa","unstructured":"Mahbubul I. Biochemistry, medicinal and food values of Jute (Corchorus capsularis L. and C. olitorius L.) leaf: a review. Int J Enhanced Res Sci Technol 2013;2:35\u201344."},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_017_w2aab3b7c13b1b6b1ab2b1c17Aa","doi-asserted-by":"crossref","unstructured":"Das AK, Bag S, Sahu R, Dua TK, Sinha MK, Gangopadhyay M, et al. Protective effect of Corchorus olitorius leaves on sodium arsenite-induced toxicity in experimental rats. Food Chem Toxicol 2010;48:326\u201335.","DOI":"10.1016\/j.fct.2009.10.020"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_018_w2aab3b7c13b1b6b1ab2b1c18Aa","doi-asserted-by":"crossref","unstructured":"Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974;11:151\u201369.","DOI":"10.1159\/000136485"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_019_w2aab3b7c13b1b6b1ab2b1c19Aa","doi-asserted-by":"crossref","unstructured":"Todorich B, Olopade JO, Surguladze N, Zhang X, Neely E, Connor JR. The mechanism of vanadium-mediated developmental hypomyelination is related to destruction of oligodendrocyte progenitors through a relationship with ferritin and iron. Neurotoxic Res 2011;19:361\u201373.","DOI":"10.1007\/s12640-010-9167-1"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_020_w2aab3b7c13b1b6b1ab2b1c20Aa","unstructured":"Sunanda P. Butanolic fraction of Moringa oleifera Lam. (Moringaceae) attenuates isoprotrenol\u2013induced cardiac necrosis and oxidative stress in rats. EXCLI J 2015;14:64\u201374."},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_021_w2aab3b7c13b1b6b1ab2b1c21Aa","unstructured":"Mahendra A, Abhishek SS, Alok SW, Archana RJ. Protective effect of aqueous extract of Moringa oleifera Lam. stem bark on serum lipids, marker enzymes and heart antioxidants parameters in isoproterenol-induced cardiotoxicity in Wistar rats. Indian J Nat Prod Resour 2010;1:485\u201392."},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_022_w2aab3b7c13b1b6b1ab2b1c22Aa","unstructured":"Benita S, Sergio P, Kevin B, Behirda K, Richard R. Digoxin-mediated up-regulation of RGS2 protein against cardiac injury. J Pharmacol Exp Toxicol 2016;115:231571."},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_023_w2aab3b7c13b1b6b1ab2b1c23Aa","doi-asserted-by":"crossref","unstructured":"Balazs T, Ferrans VJ. Cardiac lesions induced by chemicals. Environ Health Perspect 1978;26:181\u201391.","DOI":"10.1289\/ehp.7826181"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_024_w2aab3b7c13b1b6b1ab2b1c24Aa","doi-asserted-by":"crossref","unstructured":"Chen R, Wang J, Zhang Y, Tang S, Zhan S. Key factors of susceptibility to antituberculosis drug-induced hepatotoxicity. Arch Toxicol 2015;89:883\u201397.","DOI":"10.1007\/s00204-015-1473-1"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_025_w2aab3b7c13b1b6b1ab2b1c25Aa","doi-asserted-by":"crossref","unstructured":"Alderman JJ, Shah S, Foreman JC, Chain B. The role of advanced oxidation protein products in regulation of dendritic cell function. Free Radic Biol Med 2002;32:377\u201385.","DOI":"10.1016\/S0891-5849(01)00735-3"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_026_w2aab3b7c13b1b6b1ab2b1c26Aa","doi-asserted-by":"crossref","unstructured":"Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S. Adipokines: molecular link between obesity and atherosclerosis. Am J Physiol 2005;288:2013\u201341.","DOI":"10.1152\/ajpheart.01058.2004"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_027_w2aab3b7c13b1b6b1ab2b1c27Aa","doi-asserted-by":"crossref","unstructured":"Thompson D, Pepys MB, Wood SP. The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure 1999;7:169\u201377.","DOI":"10.1016\/S0969-2126(99)80023-9"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_028_w2aab3b7c13b1b6b1ab2b1c28Aa","doi-asserted-by":"crossref","unstructured":"Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 1996;87:565\u201376.","DOI":"10.1016\/S0092-8674(00)81375-6"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_029_w2aab3b7c13b1b6b1ab2b1c29Aa","doi-asserted-by":"crossref","unstructured":"Frantz S, Hu K, Bayer B, Gerondakis S, Strotmann J, Adamek A. Absence of NF-kB subunit p50 improves heart failure after myocardial infarction. FASEB J 2006;20:1918\u201320.","DOI":"10.1096\/fj.05-5133fje"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_030_w2aab3b7c13b1b6b1ab2b1c30Aa","doi-asserted-by":"crossref","unstructured":"Kawano S, Kubota T, Monden Y, Tsutsumi T, Inoue T, Kawamura N, et al. Blockade of NF-kB improves cardiac function and survival after myocardial infarction. Am J Physiol Heart Circ Physiol 2006;291:H1337\u201344.","DOI":"10.1152\/ajpheart.01175.2005"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_031_w2aab3b7c13b1b6b1ab2b1c31Aa","doi-asserted-by":"crossref","unstructured":"Prabhu SD, Chandrasekar B, Murray DR, Freeman GL. Beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling. Circulation 2000;101:2103\u20139.","DOI":"10.1161\/01.CIR.101.17.2103"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_032_w2aab3b7c13b1b6b1ab2b1c32Aa","doi-asserted-by":"crossref","unstructured":"Leon B, Lee R, Christine M. The role of NF-kappa B-1 and NFkappa B-2-mediated resistance to apoptosis in lymphomas. Proc Natl Acad Sci 2006;103:9220\u20135.","DOI":"10.1073\/pnas.0507809103"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_033_w2aab3b7c13b1b6b1ab2b1c33Aa","unstructured":"Tak W, Mak LH, Daniela G, Filio B. P53 regulates the cardiac transcriptonme. J Med Sci 2017;10:1073."},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_034_w2aab3b7c13b1b6b1ab2b1c34Aa","doi-asserted-by":"crossref","unstructured":"Tsai-Ching H, Chun-Ching C, Yi-Wen W, Bor-Show T. Effects of cystamine on antioxidant activities and regulatory T cells in lupus-prone mice. J Cell Mol Med 2013;17:1308\u201315.","DOI":"10.1111\/jcmm.12107"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_035_w2aab3b7c13b1b6b1ab2b1c35Aa","doi-asserted-by":"crossref","unstructured":"Hersch SM, Ferrante RJ. Cystamine in neurodegenerative disease. Neurotherapeutics 2004;1:298\u2013306.","DOI":"10.1007\/BF03206614"},{"key":"2025121209261901798_j_jbcpp-2019-0108_ref_036_w2aab3b7c13b1b6b1ab2b1c36Aa","doi-asserted-by":"crossref","unstructured":"Lorand L, Graham RM. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol 2003;4:140\u201356.","DOI":"10.1038\/nrm1014"}],"container-title":["Journal of Basic and Clinical Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/jbcpp\/31\/5\/article-20190108.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2019-0108\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2019-0108\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:27:36Z","timestamp":1765542456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jbcpp-2019-0108\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,4,21]]},"published-print":{"date-parts":[[2020,8,26]]}},"alternative-id":["10.1515\/jbcpp-2019-0108"],"URL":"https:\/\/doi.org\/10.1515\/jbcpp-2019-0108","relation":{},"ISSN":["2191-0286","0792-6855"],"issn-type":[{"value":"2191-0286","type":"electronic"},{"value":"0792-6855","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4,21]]},"article-number":"20190108"}}