{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:03:18Z","timestamp":1782741798944,"version":"3.54.5"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2019-0274_abs_001_w2aab3b7c47b1b6b1aab1c14b2Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The present study attempts to understand the role of supraspinal nociceptive pain modulation in typical trigeminal neuralgia (TN) patients by using a conditioned pain modulation paradigm and estimation of plasma levels of two important neuromodulators; Calcitonin Gene-Related Peptide and\u00a0\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -endorphin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0274_abs_002_w2aab3b7c47b1b6b1aab1c14b3Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty TN patients and 20 healthy, age and gender-matched subjects participated in the study. The participants' hot pain thresholds (HPT) were measured over their affected side on the face. Testing sites were matched for healthy controls. For the conditioned pain modulation their contralateral foot was immersed in noxious cold (5\u00a0\u00b0C) water bath (conditioning stimuli) for 30\u00a0s and HPT (testing stimuli) was determined before, during and till 5\u00a0min after the immersion. Plasma Calcitonin Gene-Related Peptide and\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -endorphin levels were estimated to understand their role in disease pathogenesis and pain modulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0274_abs_003_w2aab3b7c47b1b6b1aab1c14b4Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Change in HPT during foot immersion was significantly higher in healthy controls compared to TN patients (p&lt;0.0001). The changes recorded in HPT in patients, were significant only in 2nd and 3rd minute post immersion. While in healthy controls, the effect lasted till the 4th minute. The concentration of beta-endorphin was significantly lower in TN patients (p=0.003) when compared to healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0274_abs_004_w2aab3b7c47b1b6b1aab1c14b5Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The results suggest that there is an impairment in supraspinal pain modulation also known as Diffuse Noxious Inhibitory Controls in typical TN and that the reduced levels of\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -endorphin may contribute to the chronic pain state experienced by patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2019-0274","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T08:16:52Z","timestamp":1594369012000},"source":"Crossref","is-referenced-by-count":6,"title":["Aberrant pain modulation in trigeminal neuralgia patients"],"prefix":"10.1515","volume":"32","author":[{"given":"Ila","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Physiology , All India Institute of Medical Sciences , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawna","family":"Mattoo","sequence":"additional","affiliation":[{"name":"Department of Physiology , All India Institute of Medical Sciences , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virender K.","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine and Critical Care , All India Institute of Medical Sciences , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Physiology , All India Institute of Medical Sciences , New Delhi , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"2025121209273616672_j_jbcpp-2019-0274_ref_001_w2aab3b7c47b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Ichida, MC, Alvarenga da Silva, L, Teixeira, MJ, de Siqueira JTT, de Siqueira, SRDT. 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