{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:41:55Z","timestamp":1784238115615,"version":"3.55.0"},"reference-count":47,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2019-0311_abs_001_w2aab3b7b6b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Autonomic dysfunction (AD) and dynamic hyperinflation (DH) have been implicated as pathophysiological mechanisms of heart failure with preserved ejection fraction (HFpEF) in chronic obstructive pulmonary disease\n                      <jats:bold>(<\/jats:bold>\n                      COPD) patients. Their association, however, remains elusive: The aims of the study were: (1) to determine the prevalence of AD and DH in non-severe COPD patients, with exertional dyspnea, without clinically overt cardio-vascular (CV) comorbidities; (2) to analyze the correlation and clinical significance between DH, AD, and maksed HFpEF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0311_abs_002_w2aab3b7b6b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We applied CPET in 68 subjects. Echocardiography was performed before CPET and 1\u20132\u00a0min after peak exercise. IC manoeuvres were applied. Patients were divided into two groups: patients with and without masked HFpEF. Wilkoff method calculated the meatabolic \u2013\u00a0chronotropic relationship (MCR). Chronotropic incompetence (CI) and abnormal HR recovery (HRR) were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0311_abs_003_w2aab3b7b6b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of CI was 77 vs. 52% in patients with\/without masked HFpEF; of abnormal HRR \u2013\u00a098 vs. 62% respectively; of DH \u2013\u00a053 vs. 29%. ICdyn was associated with AD. Univariate regression showed association between masked HFpEF, ICdyn, HRR, oxygenuptake (\u2019VO\n                      <jats:sub>2<\/jats:sub>\n                      ), \u2019VO\n                      <jats:sub>2<\/jats:sub>\n                      at anaerobic threshold, oxygen (O\n                      <jats:sub>2<\/jats:sub>\n                      ) pulse and \u2019VE\/\u2019VCO\n                      <jats:sub>2<\/jats:sub>\n                      slope. None of these parameters is an independent predictor for masked HFpEF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0311_abs_004_w2aab3b7b6b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DH, AD, and masked HFpEF are prevalent in non-severe COPD patients, who complain of exertional dyspnea and are free of clinically overt CV comorbidities. DH is independently associated with AD. Neither AD, nor DH and CPET are independent predictors for masked HFpEF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2019-0311","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T12:45:43Z","timestamp":1594730743000},"page":"179-188","source":"Crossref","is-referenced-by-count":4,"title":["The link between dynamic hyperinflation, autonomic dysfunction and exercise testing parameters with masked heart failure in patients with non-severe obstructive pulmonary disease"],"prefix":"10.1515","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-3438","authenticated-orcid":false,"given":"Radostina Vl.","family":"Cherneva","sequence":"first","affiliation":[{"name":"University Hospital for Respiratory Diseases \u201cSt. Sophia\u2019\u2019 , Han Presian 17 , Sofia , Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan Veselinov","family":"Denchev","sequence":"additional","affiliation":[{"name":"Medical Institute of the Ministry of Internal Affairs , Gen Skobelev 79 , Sofia , Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-2307","authenticated-orcid":false,"given":"Zheina Vl.","family":"Cherneva","sequence":"additional","affiliation":[{"name":"Medical Institute of the Ministry of Internal Affairs , Gen Skobelev 79 , Sofia , Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"2025121209125072712_j_jbcpp-2019-0311_ref_001_w2aab3b7b6b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Gagnon, P, Guenette, JA, Langer, D, Laviolette, L, Mainguy, V, Maltais, F, et al. 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