{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:57:25Z","timestamp":1765540645745,"version":"3.48.0"},"reference-count":8,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,26]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n Enoxaparin is a low molecular weight heparin (LMWH), which belongs to the class of anticoagulants. The drug is administered as subcutaneous injection to prevent or treat deep vein thrombosis (DVT), pulmonary embolism and ischemic complications.<\/jats:p>\n <\/jats:sec>\n \n Case Presentation<\/jats:title>\n A 57-year-old women diagnosed with acute coronary syndrome developed reactive thrombocytosis following the administration of enoxaparin subcutaneously. The blood test reports of the patient showed that there is a gradual elevation of platelet count day by day following enoxaparin administration. On an assessment using both World Health Organization\u2013Uppsala Monitoring Centre (WHO\u2013UMC) scale and Naranjo Causality Assessment Scale indicated that enoxaparin is the \u201cprobable\u201d cause for the reaction.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We conclude that reactive thrombocytosis is a probable adverse drug reaction and close monitoring of blood counts is essential, following enoxaparin injection. More studies are to be conducted to identify further complications.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/jbcpp-2019-0312","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T08:15:32Z","timestamp":1594368932000},"source":"Crossref","is-referenced-by-count":1,"title":["Enoxaparin induced reactive thrombocytosis: a rare adverse drug reaction"],"prefix":"10.1515","volume":"31","author":[{"given":"Saleel Salman","family":"Meenpidiyil","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice , Al Shifa College of Pharmacy , Perinthalmanna , Malappuram, 679325 , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihas","family":"Azeez","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice , Al Shifa College of Pharmacy , Perinthalmanna , Malappuram, 679325 , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaisakh Prasanna","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice , Al Shifa College of Pharmacy , Perinthalmanna , Malappuram, 679325 , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhanush","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice , Al Shifa College of Pharmacy , Perinthalmanna , Malappuram, 679325 , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sareena","family":"Kalathathoduuill","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice , Al Shifa College of Pharmacy , Perinthalmanna , Malappuram, 679325 , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa","family":"Thandupara","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice , Al Shifa College of Pharmacy , Perinthalmanna , Malappuram, 679325 , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed Hashik","family":"Puthukudi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice , Al Shifa College of Pharmacy , Perinthalmanna , Malappuram, 679325 , Kerala , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"2025121209153663834_j_jbcpp-2019-0312_ref_001_w2aab3b7c58b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Tripathi, KD. Essentials of medical pharmacology, 7th ed. New Delhi: Jaypee Brothers Medical Publishers; 2013:619.","DOI":"10.5005\/jp\/books\/12256"},{"key":"2025121209153663834_j_jbcpp-2019-0312_ref_002_w2aab3b7c58b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Lepercq, J, Conard, J, Borel-Derlon, A, Darmon, JY, Boudignet, O, Francoual, C, et al. Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies. An Int J Obstet Gynaecol 2001;108:1134140. https:\/\/doi.org\/10.1111\/j.1471-0528.2003.00272.x.","DOI":"10.1111\/j.1471-0528.2003.00272.x"},{"key":"2025121209153663834_j_jbcpp-2019-0312_ref_003_w2aab3b7c58b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Aydogan, T, Kanbay, M, Alici, O, Kosar, A. Incidence and etiology of thrombocytosis in an adult Turkish population. Platelets 2006;17:328\u201331. https:\/\/doi.org\/10.1080\/09537100600746573.","DOI":"10.1080\/09537100600746573"},{"key":"2025121209153663834_j_jbcpp-2019-0312_ref_004_w2aab3b7c58b1b6b1ab2b2b4Aa","doi-asserted-by":"crossref","unstructured":"Araneda, M, Krishnan, V, Hall, K, Kalbfleisch, J, Krishnaswamy, G, Krishnan, K. Reactive and clonal thrombocytosis: pro-inflammatory and hematopoietic cytokines and acute phase proteins. Southern medical journal 2001;94:417\u201320.","DOI":"10.1097\/00007611-200194040-00012"},{"key":"2025121209153663834_j_jbcpp-2019-0312_ref_005_w2aab3b7c58b1b6b1ab2b2b5Aa","doi-asserted-by":"crossref","unstructured":"Santhosh-Kumar, CR, Yohannan, MD, Higgy, KE, Al-Mashhadani, SA. Thrombocytosis in adults: analysis of 777 patients. J Int Med 1991;229:493\u20135. https:\/\/doi.org\/10.1111\/j.1365-2796.1991.tb00383.","DOI":"10.1111\/j.1365-2796.1991.tb00383.x"},{"key":"2025121209153663834_j_jbcpp-2019-0312_ref_006_w2aab3b7c58b1b6b1ab2b2b6Aa","doi-asserted-by":"crossref","unstructured":"Vo, QT, Thompson, DF. A review and assessment of drug induced thrombocytosis. Ann Pharmacother 2019;53:523\u201336. https:\/\/doi.org\/10.1177\/1060028018819450.","DOI":"10.1177\/1060028018819450"},{"key":"2025121209153663834_j_jbcpp-2019-0312_ref_007_w2aab3b7c58b1b6b1ab2b2b7Aa","doi-asserted-by":"crossref","unstructured":"Frye, JL, Thompson, DF. Drug-induced thrombocytosis. J Clin Pharm Ther 1993;18:45\u20138.","DOI":"10.1111\/j.1365-2710.1993.tb00565.x"},{"key":"2025121209153663834_j_jbcpp-2019-0312_ref_008_w2aab3b7c58b1b6b1ab2b2b8Aa","doi-asserted-by":"crossref","unstructured":"Hummel, MC, Morse, BC, Hayes, LE. Reactive thrombocytosis associated with enoxaparin. 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