{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:38:49Z","timestamp":1791988729867,"version":"4.4.0"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2019-0331_s_999_w2aab3b8d172b1b7b1aab1c14b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is a chronic disease in the joints. One of the proinflammatory cytokines that is thought to have a major role in the inflammatory process, the emergence of pain, and cartilage damage in OA is tumor necrosis factor \u03b1 (TNF-\u03b1). Meloxicam is a nonsteroidal anti-inflammatory drug class of drugs that is relatively selective in inhibiting the activity of cyclooxygenase 2 (COX-2) formation. This study is conducted to prove the change in TNF-\u03b1 level in the use of meloxicam with model in animals suffering from OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0331_s_998_w2aab3b8d172b1b7b1aab1c14b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The OA rat model was induced with sodium monoiodoacetate intra-articularly. Rats were divided into 5 groups: negative control group, positive control group, and treatment groups with various doses of meloxicam. Hyperalgesia effect was evaluated using a warm plate test, and TNF-\u03b1 level was determined using enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0331_s_997_w2aab3b8d172b1b7b1aab1c14b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The treatment groups that received meloxicam at a dose of 1.0, 3.0, or 10.0 mg\/kg body weight (BW) did not show significant differences in rat knee joint diameter (p = 0.99), but showed a significant difference in sensitivity to heat stimulation (p = 0.02) compared to the control group. Osteoarthritis rats experienced a significant reduction in TNF-\u03b1 level after being given meloxicam at a dose of 10 mg\/kg BW compared with the control group. This shows that the 10 mg\/kg BW of meloxicam is a potential dose in reducing the TNF-\u03b1 level in OA rat models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0331_s_996_w2aab3b8d172b1b7b1aab1c14b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on these data, it can be concluded that the inhibition of pain and the development of OA by meloxicam in animal models may be assigned to a decreased level of TNF-\u03b1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2019-0331","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T13:06:57Z","timestamp":1576328817000},"source":"Crossref","is-referenced-by-count":16,"title":["The change of proinflammatory cytokine tumor necrosis factor \u03b1 level in the use of meloxicam in rat model of osteoarthritis"],"prefix":"10.1515","volume":"30","author":[{"given":"Junaidi","family":"Khotib","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University , Surabaya 60115 , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naning Windi","family":"Utami","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University , Surabaya 60115 , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Apriliani","family":"Gani","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University , Surabaya 60115 , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrismawan","family":"Ardianto","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University , Surabaya 60115 , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,12,14]]},"reference":[{"key":"2025121209161529810_j_jbcpp-2019-0331_ref_001_w2aab3b8d172b1b7b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Miller RE, Miller RJ, Malfait AM. 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