{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:22:24Z","timestamp":1765542144929,"version":"3.48.0"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2019-0359_abs_001_w2aab3b7c15b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hypothyroidism adversely affects pulmonary function, which may improve by thyroxine therapy. Limited studies about the effect of hypothyroidism on spirometric parameters in adult patients were conducted in Basra, south of Iraq. Moreover, the effect of thyroxine therapy on spirometric parameters was not covered by these studies. In this study, pulmonary function in adult\u2019s hypothyroid patients was evaluated by spirometry to detect any impairment, type of impairment, and to evaluate the effect of thyroxine therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0359_abs_002_w2aab3b7c15b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comparative study was conducted in Al-Faiha Specialized Diabetes, Endocrine, and Metabolism Center (FDEMC) in Al-Faiha teaching hospital, Basrah, Iraq. Subjects are divided into four groups: uncontrolled hypothyroid group (n=72), controlled hypothyroid group (n=60), newly diagnosed hypothyroid group (n=52), and control group (n=110). Spirometry was done to all subjects in sitting position, it\u2019s repeated at least three times and the best result was recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0359_abs_003_w2aab3b7c15b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significantly (p&lt;0.05) less spirometric parameters\u00a0and more abnormal pulmonary function test\u00a0(PFT) were noticed in hypothyroid groups, the reduction were more pronounced in the uncontrolled hypothyroid group. The abnormality in PFT was mostly of\u00a0restrictive type. A significantly (p&lt;0.05) negative correlation has\u00a0been found between thyroid-stimulating hormone\u00a0(TSH)\u00a0and spirometric parameters, while the correlation of fT4\u00a0is significantly (p&lt;0.05) positive with FVC% and FEV%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0359_abs_004_w2aab3b7c15b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In hypothyroidism, high TSH and low fT4 are\u00a0recognized causes of a reduction in spirometric parameters. Therefore, spirometry can be used to detect pulmonary function changes in hypothyroidism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2019-0359","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T03:01:43Z","timestamp":1605582103000},"page":"189-195","source":"Crossref","is-referenced-by-count":0,"title":["Spirometry in adult hypothyroid patients: a comparative study"],"prefix":"10.1515","volume":"32","author":[{"given":"Rasha N.","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology , College of Pharmacy, University of Basrah , Basrah , Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haithem J.","family":"Kadhum","sequence":"additional","affiliation":[{"name":"Department of Physiology , College of Medicine, University of Basrah , Basrah , Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali R.","family":"Hashim","sequence":"additional","affiliation":[{"name":"Department of Medicine , College of Medicine, University of Basrah , Basrah , Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"2025121209221008544_j_jbcpp-2019-0359_ref_001_w2aab3b7c15b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Andersson, M, Benoist, B, Delange, F, Zupan, J. 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