{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:20:25Z","timestamp":1773951625628,"version":"3.50.1"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2019-0360_abs_001_w2aab3b7c30b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to explore the protective mechanism of caffeic acid (CAA) and chlorogenic acid (CHA) on cyclosporine (CSA) induced hypertensive rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0360_abs_002_w2aab3b7c30b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Effect of CAA and CHA on diastolic blood pressure (DBP), mean arterial pressure (MAP), angiotensin-converting enzyme (ACE), e-nucleotide triphosphate dephosphorylase (e-NTPDase), 5\u2032 nucleotidase and adenosine deaminase (ADA) activity in CSA-induced hypertensive rats were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0360_abs_003_w2aab3b7c30b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CAA and CHA administration stabilized hypertensive effect caused by CSA administration. Also, altered activity of ACE (lung), e-NTPDase, 5\u2032 nucleotidase, ADA as well as elevated malondiadehyde (MDA) level was restored in all the treated hypertensive rats in comparison with the untreated hypertensive rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2019-0360_abs_004_w2aab3b7c30b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hence, these observed results could underlie some of the mechanisms through which CAA and CHA could offer antihypertensive effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2019-0360","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T15:48:47Z","timestamp":1601567327000},"page":"169-177","source":"Crossref","is-referenced-by-count":18,"title":["Caffeic and chlorogenic acids modulate altered activity of key enzymes linked to hypertension in cyclosporine-induced hypertensive rats"],"prefix":"10.1515","volume":"32","author":[{"given":"Odunayo M.","family":"Agunloye","sequence":"first","affiliation":[{"name":"Department of Biochemistry , Federal University of Technology , Akure , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganiyu","family":"Oboh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Federal University of Technology , Akure , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gbemisola T.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Federal University of Technology , Akure , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ademola A.","family":"Oyagbemi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine , University of Ibadan , Ibadan , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"2025121209221007801_j_jbcpp-2019-0360_ref_001_w2aab3b7c30b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Lopez-Sendon, J, Swedberg, K, McMurray, J, Tamargo, J, Maggioni, AP, Dargie, H, et al. 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