{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:12:26Z","timestamp":1776312746363,"version":"3.50.1"},"reference-count":43,"publisher":"Walter de Gruyter GmbH","issue":"2","funder":[{"DOI":"10.13039\/501100005756","name":"Shahrekord University of Medical Sciences","doi-asserted-by":"publisher","award":["2134"],"award-info":[{"award-number":["2134"]}],"id":[{"id":"10.13039\/501100005756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2020-0021_abs_001_w2aab3b7c68b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Previous studies have suggested antidepressant properties for modafinil; however, the underlying mechanisms mediating the antidepressant effect of modafinil have not been well recognized in clinical and animal studies. Nitric oxide (NO) is involved in the pathophysiology of depression. We attempted to investigate the possible role of NO in the antidepressant-like effect of modafinil in mouse forced swimming test (FST) and tail suspension test (TST).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0021_abs_002_w2aab3b7c68b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The antidepressant-like effect of modafinil (25, 50 and 75\u00a0mg\/kg), alone and in combination with\n                      <jats:sc>l<\/jats:sc>\n                      -arginine,\n                      <jats:sc>l<\/jats:sc>\n                      -arg, (100\u00a0mg\/kg) and N\n                      <jats:sup>G<\/jats:sup>\n                      -\n                      <jats:sc>l<\/jats:sc>\n                      -arginine methyl ester,\n                      <jats:sc>l<\/jats:sc>\n                      -NAME (5\u00a0mg\/kg), was evaluated using FST and TST. Following behavioral tests, the hippocampi were dissected out to measure nitrite levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0021_abs_003_w2aab3b7c68b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Findings suggested that administration of modafinil at doses of 50 and 75\u00a0mg\/kg significantly reduced immobility time in the FST and TST. Furthermore, administration of\n                      <jats:sc>l<\/jats:sc>\n                      -arg and\n                      <jats:sc>l<\/jats:sc>\n                      -NAME increased and decreased, respectively, the immobility time in the FST and TST. We showed that co-administration of a sub-effective dose of modafinil (25\u00a0mg\/kg) plus\n                      <jats:sc>l<\/jats:sc>\n                      -NAME potentiated the antidepressant-like effect of the sub-effective dose of modafinil. In addition, co-treatment of an effective dose of modafinil (75\u00a0mg\/kg) with\n                      <jats:sc>l<\/jats:sc>\n                      -arg attenuated the antidepressant-like effect of the effective dose of modafinil. We showed that the antidepressant-like effect of modafinil is associated with decreased nitrite levels in the hippocampus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0021_abs_004_w2aab3b7c68b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings for the first time support that the modulation of NO, partially at least, is involved in the antidepressant-like effect of modafinil in mouse FST and TST.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2020-0021","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T15:46:26Z","timestamp":1601912786000},"page":"25-31","source":"Crossref","is-referenced-by-count":8,"title":["Nitric oxide mediates the antidepressant-like effect of modafinil in mouse forced swimming and tail suspension tests"],"prefix":"10.1515","volume":"32","author":[{"given":"Hossein","family":"Omidi-Ardali","sequence":"first","affiliation":[{"name":"Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences , Shahrekord , Islamic Republic of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abolfazl Ghasemi","family":"Badi","sequence":"additional","affiliation":[{"name":"Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences , Shahrekord , Islamic Republic of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Saghaei","sequence":"additional","affiliation":[{"name":"Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences , Shahrekord , Islamic Republic of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Amini-Khoei","sequence":"additional","affiliation":[{"name":"Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences , Shahrekord , Islamic Republic of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"2025121209234539591_j_jbcpp-2020-0021_ref_001_w2aab3b7c68b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Kessler, RC, Aguilar-Gaxiola, S, Alonso, J, Chatterji, S, Lee, S, Ormel, J, et al. 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