{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:30:26Z","timestamp":1765542626784,"version":"3.48.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2020-0034_abs_001_w2aab3b7c81b1b6b1aab1c15b1Aa\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study has characterized the phytoconstituents and evaluated the\n                      <jats:italic>in vitro<\/jats:italic>\n                      antioxidant and hepatoprotective effects of\n                      <jats:italic>Pleurotus tuber-regium<\/jats:italic>\n                      induced by carbon tetrachloride (CCl\n                      <jats:sub>4<\/jats:sub>\n                      ).\n                      <jats:italic>In\u00a0vitro<\/jats:italic>\n                      antioxidant assay of ethanol extract of\n                      <jats:italic>P.\u00a0tuber-regium<\/jats:italic>\n                      and gas chromatography-mass spectrometry analyses to identify the phytoconstituents were carried out.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0034_abs_002_w2aab3b7c81b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty rats were divided into six groups of 10 animals in each group and treated as follows for 13\u00a0weeks. Group I (control) received 3\u00a0mL\/kg olive oil intraperitoneal twice weekly in addition to feed and water\n                      <jats:italic>ad libitum<\/jats:italic>\n                      . Group II received CCl\n                      <jats:sub>4<\/jats:sub>\n                      3\u00a0mL\/kg twice weekly. Groups III, IV and V received 100, 200 and 500\u00a0mg\/kg wild edible\n                      <jats:italic>P.\u00a0tuber-regium<\/jats:italic>\n                      mixed with feed by ingestion daily in addition to 3\u00a0mL\/kg CCl\n                      <jats:sub>4<\/jats:sub>\n                      twice weekly, respectively. Group VI received 500\u00a0mg\n                      <jats:italic>P.\u00a0tuber-regium<\/jats:italic>\n                      daily. Liver and body weights were recorded. Liver function tests, oxidative stress biomarkers, bilirubin, ascorbic acid and \u03b1-tocopherol were assayed. Histopathology of the liver was carried out. The gas chromatography-mass spectroscopy analysis yielded 10 antioxidants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0034_abs_003_w2aab3b7c81b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CCl\n                      <jats:sub>4<\/jats:sub>\n                      increased the levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, bilirubin and malondialdehyde from 24\u00b11.778\u00a0iu\/L, 53\u00b13.7 iu\/L, 257\u00b119\u00a0iu\/L, 0.45\u00b10.03\u00a0mg\/dL and 1.90\u00b10.42\u00a0\u03bcmol\/L in the control group to 48\u00b12.5\u00a0iu\/L, 81\u00b12.10 iu\/L, 495\u00b138\u00a0iu\/L, 1.20\u00b10.09\u00a0mg\/dL and 14.0\u00b12.6\u00a0\u03bcmol\/L in the treated group, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0034_abs_004_w2aab3b7c81b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>P.\u00a0tuber-regium<\/jats:italic>\n                      prevented the necrosis, edema and vein congestion observed in the CCl\n                      <jats:sub>4<\/jats:sub>\n                      -only group.\n                      <jats:italic>P.\u00a0tuber-regium<\/jats:italic>\n                      is effective in protecting the liver against CCl\n                      <jats:sub>4<\/jats:sub>\n                      -induced damage.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2020-0034","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T03:53:26Z","timestamp":1598414006000},"page":"67-78","source":"Crossref","is-referenced-by-count":4,"title":["<i>In vitro<\/i>\n                    antioxidants and hepatoprotective effects of\n                    <i>Pleurotus tuber-regium<\/i>\n                    on carbon tetrachloride\u2013treated rats"],"prefix":"10.1515","volume":"32","author":[{"given":"Kenneth O.","family":"Okolo","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy , Madonna University , Port Harcourt , Elele Rivers State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-9858","authenticated-orcid":false,"given":"Orish. 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