{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:16:32Z","timestamp":1788570992188,"version":"build-2803163510"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2020-0087_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The threat to human health or the surroundings by the use of artificial fruit ripening agents has become a global concern. Calcium carbide (CaC\n                      <jats:sub>2<\/jats:sub>\n                      ) and ethylene glycol (EG) are the two widely using ripening agents. The present study evaluates the toxic effect of chronic exposures of CaC\n                      <jats:sub>2<\/jats:sub>\n                      and EG in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0087_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CaC\n                      <jats:sub>2<\/jats:sub>\n                      and EG were administered to the rats for 180\u00a0days orally. The alterations in oxido-reduction status, haematological, biochemical and histopathological parameters were analysed. Arsenic content in CaC\n                      <jats:sub>2<\/jats:sub>\n                      and animal samples were detected by atomic absorption spectrometer and phosphorus by molybdate-UV method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0087_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At chronic doses, there were no significant alterations in haematological and biochemical parameters except in creatinine level especially by EG. However, histological details revealed microvesicular fatty change in liver, corpuscles degeneration in kidney and lymphocytes infiltration in various tissues. In intestine, the mucosal lesion scoring was found high (p&lt;0.01). SOD and CAT activities and GSH level was reduced significantly by CaC\n                      <jats:sub>2<\/jats:sub>\n                      administration (p&lt;0.01). Arsenic and phosphorus detected is above the toxic level: 7.222 and 13.91\u00a0mg\/dL in CaC\n                      <jats:sub>2<\/jats:sub>\n                      , 1.634 and 6.22\u00a0mg\/dL in blood and 0.563 and 6.99\u00a0mg\/dL in liver, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0087_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The study suggests that the industrial grade CaC\n                      <jats:sub>2<\/jats:sub>\n                      and EG induce systemic toxicity to rats and the liver is the most susceptible organ. The CaC\n                      <jats:sub>2<\/jats:sub>\n                      and EG toxicity is mediated through the upset of redox balance and subsequent inflammatory responses. This could be due to the presence of arsenic and phosphorus contents that detected above the normal level in the industrial grade CaC\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2020-0087","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T18:34:11Z","timestamp":1616783651000},"page":"265-271","source":"Crossref","is-referenced-by-count":7,"title":["Chronic exposure of industrial grade calcium carbide and ethylene glycol alter histological architecture of systemic organs by disrupting redox balance in rat"],"prefix":"10.1515","volume":"33","author":[{"given":"Markose","family":"Bini","sequence":"first","affiliation":[{"name":"Department of Anatomy , Bharath Institute of Higher Education and Research , Chennai , India"},{"name":"Department of Anatomy , Amala Institute of Medical Sciences , Thrissur , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargavan","family":"Rajesh","sequence":"additional","affiliation":[{"name":"Department of Anatomy , Sri Lakshmi Narayana Institute of Medical Sciences , Puducherry , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-3814","authenticated-orcid":false,"given":"Thekkekara Devassy","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Amala Cancer Research Centre , Thrissur , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"2025121209185718842_j_jbcpp-2020-0087_ref_001","doi-asserted-by":"crossref","unstructured":"Prasanna, V, Prabha, TN, Tharanathan, RN. 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