{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:35:28Z","timestamp":1765542928037,"version":"3.48.0"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2020-0281_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Lead primarily affects male reproductive functions via hormonal imbalance and morphological damage to the testicular tissue with significant alteration in sperm profile and oxidative markers. Though, different studies have reported that\n                      <jats:italic>Cocos nucifera L<\/jats:italic>\n                      . oil has a wide range of biological effects, this study aimed at investigating the effect of\n                      <jats:italic>Cocos nucifera L.<\/jats:italic>\n                      oil on lead acetate-induced reproductive toxicity in male Wistar rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0281_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty (20) sexually matured male Wistar rats (55\u201365\u00a0days) were randomly distributed into four groups (n=5). Group I (negative control)\u2014distilled water orally for\u00a056\u00a0days, Group II (positive control)\u20145\u00a0mg\/kg bwt lead acetate intraperitoneally\n                      <jats:italic>(i.p.)<\/jats:italic>\n                      for 14\u00a0days, Group III\u20146.7\u00a0mL\/kg bwt\n                      <jats:italic>Cocos nucifera L<\/jats:italic>\n                      . oil orally for 56\u00a0days and Group IV\u2014lead acetate intraperitoneally\n                      <jats:italic>(i.p.)<\/jats:italic>\n                      for 14\u00a0days and\n                      <jats:italic>Cocos nucifera L<\/jats:italic>\n                      . oil for orally for 56\u00a0days. Rats were sacrificed by diethyl ether, after which the serum, testis and epididymis were collected and used for semen analysis, biochemical and histological analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0281_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The lead acetate significantly increases (p&lt;0.05) testicular and epididymal malondialdehyde (MDA) levels, while a significant reduction (p&lt;0.05) in sperm parameters, organ weight, testosterone and luteinizing hormone was observed when compared with the negative control. The coadministration of\n                      <jats:italic>Cocos nucifera<\/jats:italic>\n                      oil with lead acetate significantly increases (p&lt;0.05) testosterone, luteinizing hormone, sperm parameters and organ weight, with a significant decrease (p&lt;0.05) in MDA levels compared with positive control. Histological analysis showed that lead acetate distorts testicular cytoarchitecture and germ cell integrity while this was normalized in the cotreated group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0281_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Cocos nucifera<\/jats:italic>\n                      oil attenuates the deleterious effects of lead acetate in male Wistar rats, which could be attributed to its polyphenol content and antioxidant properties.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2020-0281","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T16:04:47Z","timestamp":1615651487000},"page":"297-303","source":"Crossref","is-referenced-by-count":2,"title":["<i>Cocos nucifera L.<\/i>\n                    oil alleviates lead acetate-induced reproductive toxicity in sexually-matured male Wistar rats"],"prefix":"10.1515","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6327-8435","authenticated-orcid":false,"given":"Olugbemi T.","family":"Olaniyan","sequence":"first","affiliation":[{"name":"Department of Physiology, Laboratory for Reproductive Biology and Developmental Programming, Edo State University Uzairue , Iyamho , Edo State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olakunle A.","family":"Ojewale","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus , Bushenyi , Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-5384","authenticated-orcid":false,"given":"Ayobami","family":"Dare","sequence":"additional","affiliation":[{"name":"Department of Physiology , School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal , Durban , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olufemi","family":"Adebayo","sequence":"additional","affiliation":[{"name":"Department of Physiology , Bingham University Karu , New Karu , Nasarawa State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Enyojo","sequence":"additional","affiliation":[{"name":"Department of Physiology , Bingham University Karu , New Karu , Nasarawa State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria E.","family":"Okotie","sequence":"additional","affiliation":[{"name":"Department of Physiology , University of Ibadan , Ibadan , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles O.","family":"Adetunji","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Applied Microbiology, Biotechnology and Nanotechnology Laboratory, Edo State University Uzairue , Iyamho , Edo State , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bello Sanusi","family":"Mada","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Ahmadu Bello University , Zaria , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bamidele J.","family":"Okoli","sequence":"additional","affiliation":[{"name":"Institute of Chemical and Biotechnology, Vaal University of Technology, Southern Gauteng Science and Technology Park , Sebokeng , South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olugbenga O.","family":"Eweoya","sequence":"additional","affiliation":[{"name":"School of Medicine and Allied Health Sciences, University of the Gambia , Banjul , The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"2025121209292379590_j_jbcpp-2020-0281_ref_001","doi-asserted-by":"crossref","unstructured":"Pasqualotto, FF, Lucon, AM, Sobreiro, BP, Pasqualotto, EB, Arap, S. 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