{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:23:56Z","timestamp":1771460636539,"version":"3.50.1"},"reference-count":52,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2020-0307_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study examined the possible protective roles of exogenous glycine (Gly) and L-Arginine (\n                      <jats:sc>l<\/jats:sc>\n                      -Arg) against Diclofenac (DIC)-induced gastro-duodenal damage in rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0307_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Rats were divided into Group A (control), Group B (DIC group) and Groups C\u2013F which were pre-treated for five\u00a0days with Gly1 (250\u00a0mg\/kg), Gly2 (500\u00a0mg\/kg),\n                      <jats:sc>l<\/jats:sc>\n                      -Arg1 (200\u00a0mg\/kg) and\n                      <jats:sc>l<\/jats:sc>\n                      -Arg2 (400\u00a0mg\/kg), respectively, before co-treatment with DIC for another three days. Hematological, biochemical and histopathological analyses were then carried out.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0307_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DIC produced significant (p&lt;0.05) reduction in PCV (13.82%), Hb (46.58%), RBC (30.53%), serum total protein (32.72%), albumin (28.44%) and globulin (38.01%) along with significant (p&lt;0.05) elevation of serum MPO activity (83.30%), when compared with control. In addition, DIC increased gastric H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      and MDA levels by 33.93 and 48.59%, respectively, while the duodenal levels of the same parameters increased by 19.43 and 85.56%, respectively. Moreover, SOD, GPx and GST activities in the DIC group were significantly (p&lt;0.05) reduced in the stomach (21.12, 24.35 and 51.28%, respectively) and duodenum (30.59, 16.35 and 37.90%, respectively), compared to control. Treatment with Gly and\n                      <jats:sc>l<\/jats:sc>\n                      -Arg resulted in significant amelioration of the DIC-induced alterations although\n                      <jats:sc>l<\/jats:sc>\n                      -Arg produced better amelioration of RBC (29.78%), total protein (10.12%), albumin (9.93%) and MPO (65.01%), compared to the DIC group. The protective effects of both amino acids against oxidative stress parameters and histological lesions were largely similar.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0307_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The data from this study suggest that Gly or\n                      <jats:sc>l<\/jats:sc>\n                      -Arg prevented DIC-induced gastro-duodenal toxicity and might, therefore be useful in improving the therapeutic index of DIC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2020-0307","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T04:43:05Z","timestamp":1612932185000},"page":"285-295","source":"Crossref","is-referenced-by-count":2,"title":["Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress"],"prefix":"10.1515","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-4595","authenticated-orcid":false,"given":"Akinleye Stephen","family":"Akinrinde","sequence":"first","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine , University of Ibadan , Ibadan , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halimot Olawalarami","family":"Hameed","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine , University of Ibadan , Ibadan , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_001","doi-asserted-by":"crossref","unstructured":"Syed, M, Skonberg, C, Hansen, SH. Mitochondrial toxicity of Diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: possible role in drug-induced liver injury (DILI). Toxicol In Vitro 2016;31:93\u2013102. https:\/\/doi.org\/10.1016\/j.tiv.2015.11.020.","DOI":"10.1016\/j.tiv.2015.11.020"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_002","doi-asserted-by":"crossref","unstructured":"Zerbini, LF, Tamura, RE, Correa, RG, Czibere, A, Cordeiro, J, Bhasin, M, et al.. Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-\u039ab inhibitors in ovarian cancer therapy. PloS One 2011;6:24285. https:\/\/doi.org\/10.1371\/journal.pone.0024285.","DOI":"10.1371\/journal.pone.0024285"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_003","unstructured":"Aydin, GI, Alparshan, G, Umen, K, Meral, NC, Ekr, UE, Nermin, K, et al.. Histopathologic changes in liver and renal tissues induced by different doses of Diclofenac sodium in rats. Turk J Vet Anim Sci 2003;27:1131\u201340."},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_004","doi-asserted-by":"crossref","unstructured":"Gomez-Lechon, MJ, Ponsoda, X, O\u2019Connor, E, Donato, T, Castell, JV, Jover, R. Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS. Biochem Pharmacol 2003;66:2155\u201367. https:\/\/doi.org\/10.1016\/j.bcp.2003.08.003.","DOI":"10.1016\/j.bcp.2003.08.003"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_005","doi-asserted-by":"crossref","unstructured":"Dorado, P, Berecz, R, Caceres, MC, LLerena, A. Analysis of diclofenac and its metabolites by high-performance liquid chromatography: relevance of CYP2C9 genotype in diclofenac urinary metabolic ratios. J Chromatogr B 2003;789:437\u201342.","DOI":"10.1016\/S1570-0232(03)00137-5"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_006","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez, E, Guti\u00e9rrez, E, Galeano, C, Chevia, C, de Sequera, P, Bernis, C, et al.. Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int 2008;73:940\u20136. https:\/\/doi.org\/10.1038\/sj.ki.5002776.","DOI":"10.1038\/sj.ki.5002776"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_007","doi-asserted-by":"crossref","unstructured":"Satoh, H, Amagase, K, Takeuchi, K. Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility. J Pharmacol Exp Therapeut 2012;343:270\u20137. https:\/\/doi.org\/10.1124\/jpet.112.197475.","DOI":"10.1124\/jpet.112.197475"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_008","doi-asserted-by":"crossref","unstructured":"Norgard, B, Perdersen, L, Johnsen, SP, Tarone, RE, McLaughlin, JK, Friis, S, et al.. Cox-2 selective inhibitors and the risk of upper gastrointestinal bleeding in high-risk patients with previous gastrointestinal diseases: a population-based case-control study. Aliment Pharmacol Ther 2004;19:817\u201325.","DOI":"10.1111\/j.1365-2036.2004.01913.x"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_009","doi-asserted-by":"crossref","unstructured":"Yang, Z, Liao, SF. Physiological effects of dietary amino acids on gut health and functions of swine. Front Vet Sci 2019;6:169. https:\/\/doi.org\/10.3389\/fvets.2019.00169.","DOI":"10.3389\/fvets.2019.00169"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_010","doi-asserted-by":"crossref","unstructured":"Wang, WW, Qiao, SY, Li, DF. Amino acids and gut function. Amino Acids 2009;37:105\u201310. https:\/\/doi.org\/10.1007\/s00726-008-0152-4.","DOI":"10.1007\/s00726-008-0152-4"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_011","doi-asserted-by":"crossref","unstructured":"Bin, P, Huang, R, Zhou, X. Oxidation resistance of the sulfur amino acids: methionine and Cysteine. BioMed Res Int 2017. https:\/\/doi.org\/10.1155\/2017\/9584932.","DOI":"10.1155\/2017\/9584932"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_012","doi-asserted-by":"crossref","unstructured":"Gannon, MC, Nuttall, JA, Nuttall, FQ. The metabolic response to ingested glycine. 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Alternative Med Rev 2002;7:512\u201322."},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_016","doi-asserted-by":"crossref","unstructured":"Knowles, RG, Moncada, S. Nitric oxide synthase in mammals. Biochem J 1994;298:249\u201358. https:\/\/doi.org\/10.1042\/bj2980249.","DOI":"10.1042\/bj2980249"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_017","doi-asserted-by":"crossref","unstructured":"Wu, G, Meininger, CJ. Arginine nutrition and cardiovascular function. J Nutr 2000;130:2626\u20139. https:\/\/doi.org\/10.1093\/jn\/130.11.2626.","DOI":"10.1093\/jn\/130.11.2626"},{"key":"2025121209292381268_j_jbcpp-2020-0307_ref_018","doi-asserted-by":"crossref","unstructured":"Sukhotnik, I, Helou, H, Mogllner, J, Lurie, M, Bernsteyn, A, Coran, AG, et al.. Oral arginine improves intestinal recovery following ischemia-reperfusion injury in rat. 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