{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:43:19Z","timestamp":1768826599848,"version":"3.49.0"},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2020-0327_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      In this clinical trial, the effect of aqueous extract of\n                      <jats:italic>Berberis vulgaris<\/jats:italic>\n                      L. was investigated on opiate withdrawal syndrome, depression, anxiety, stress, and sleep quality in opioid addicts which were under methadone maintenance therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0327_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      For this purpose, 52 opiate addicts were randomly selected of whom 28 received 500\u00a0mg capsules of\n                      <jats:italic>B.\u00a0vulgaris<\/jats:italic>\n                      extract (treatment) and the rest received 500\u00a0mg of starch capsules (placebo), twice daily for 4\u00a0weeks. Signs and symptoms of opiate withdrawal syndrome, depression, anxiety, stress, and sleep quality were assessed through Clinical Opiate Withdrawal Scale (COWS), Pittsburgh Sleep Quality Inventory (PSQI) and Depression Anxiety Stress Scales-21 (DASS-21) questionnaires at baseline and after 7, 14, and 28\u00a0days of receiving intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0327_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Signs and symptoms of opiate withdrawal syndrome were significantly improved in those who received the extract for 1\u00a0month compared to the placebo group. However, there were no significant differences in depression, anxiety, stress, and sleep quality scores in the treatment group compared to those in the placebo group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0327_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The extract of\n                      <jats:italic>B.\u00a0vulgaris<\/jats:italic>\n                      root as a traditional herbal product in combination with methadone could improve the symptoms and signs of opiate withdrawal.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2020-0327","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T18:12:00Z","timestamp":1624126320000},"page":"465-472","source":"Crossref","is-referenced-by-count":7,"title":["The effects of\n                    <i>Berberis vulgaris<\/i>\n                    L. root extract on the opiate withdrawal syndrome and psychological factors: a randomized double-blind clinical trial"],"prefix":"10.1515","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5868-9782","authenticated-orcid":false,"given":"Fatemeh","family":"Dabaghzadeh","sequence":"first","affiliation":[{"name":"Pharm D, Department of Clinical Pharmacy , Faculty of Pharmacy, Kerman University of Medical Sciences , Kerman , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Sharififar","sequence":"additional","affiliation":[{"name":"Pharm D, Herbal and Traditional Medicine Research Center, Kerman University of Medical Sciences , Kerman , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir-Mohammad","family":"Ahmadzadeh","sequence":"additional","affiliation":[{"name":"Pharm D, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences , Kerman , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-6550","authenticated-orcid":false,"given":"Somayyeh","family":"Karami-Mohajeri","sequence":"additional","affiliation":[{"name":"Pharm D, Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences , Kerman , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"2025121209194294209_j_jbcpp-2020-0327_ref_001","unstructured":"Li, X, Kosten, T. 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