{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:53:12Z","timestamp":1775235192755,"version":"3.50.1"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"4","funder":[{"name":"World Class Research","award":["945\/UN3.14\/PT\/2020"],"award-info":[{"award-number":["945\/UN3.14\/PT\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jbcpp-2020-0397_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The finding of alternative medicine for malarial treatment still has become a substantial demand. The plant is one of the potential sources of drugs, among other natural sources. Artocarpus species showed great potential as the antimalarial source. This study aims to obtain active antimalarial fractions from\n                      <jats:italic>Artocarpus sericicarpus<\/jats:italic>\n                      stem bark.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0397_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Stem bark of\n                      <jats:italic>A.\u00a0sericicarpus<\/jats:italic>\n                      was extracted by ultrasonic-assisted extraction method using n-hexane, dichloromethane, and methanol as solvents. Fractionation of dichloromethane extract was conducted by open column chromatography using octadecyl silica as a stationary phase and gradient acetonitrile-water as a mobile phase. The antimalarial activity was determined by lactate dehydrogenase (LDH) assay against\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      3D7 strain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0397_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>A.\u00a0sericicarpus<\/jats:italic>\n                      n-hexane, dichloromethane, and methanol extracts were showed antimalarial activity with an IC\n                      <jats:sub>50<\/jats:sub>\n                      value of &gt;4, 2.11, and &gt;4\u00a0\u03bcg\/mL, respectively. Fractionation of dichloromethane extract was obtained 13 fractions. Seven of the 13 fractions tested showed antimalarial activity. Fraction-6 performed the highest inhibition with an IC\n                      <jats:sub>50<\/jats:sub>\n                      value of 1.53\u00a0\u00b1\u00a00.04\u00a0\u03bcg\/mL. Phytochemistry screening revealed that Fraction-6 contains flavonoid, polyphenol, and terpenoid compounds that can take a role in its antimalarial activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jbcpp-2020-0397_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>A.\u00a0sericicarpus<\/jats:italic>\n                      contains antimalarial substances mainly in Fraction-6, which strongly inhibited the growth of\n                      <jats:italic>P.\u00a0falciparum<\/jats:italic>\n                      . The flavonoid, polyphenol, and terpenoid compounds were identified in Fraction-6, which need to be further isolated to obtain and elucidate the active antimalarial compounds.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jbcpp-2020-0397","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T12:45:59Z","timestamp":1625229959000},"page":"853-858","source":"Crossref","is-referenced-by-count":4,"title":["<i>Artocarpus sericicarpus<\/i>\n                    stem bark contains antimalarial substances against\n                    <i>Plasmodium falciparum<\/i>"],"prefix":"10.1515","volume":"32","author":[{"given":"Lidya","family":"Tumewu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga , Surabaya , Indonesia"},{"name":"Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutfah Qurrota","family":"A\u2019yun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilkatul","family":"Ilmi","sequence":"additional","affiliation":[{"name":"Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achmad Fuad","family":"Hafid","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga , Surabaya , Indonesia"},{"name":"Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aty","family":"Widyawaruyanti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga , Surabaya , Indonesia"},{"name":"Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga , Surabaya , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"2025121209225082841_j_jbcpp-2020-0397_ref_001","unstructured":"WHO. 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